원자력법의 개정

배재웅 한국원자력산업회의 1996 원자력산업 Vol.16 No.12

96년 6월 25일 제245차 원자력위원회에서 `원자력 사업 추진 체제 조정 방안`을 확정함에 따라, 그 후속 조치로서 개정 추진하게 된 제13차 원자력법 중 개정 법률안이 96년 11월 30일 제17차 국회 본회의에서 의결되었다. 이번 개정으로 원자력 연구 개발에 필요한 재원을 안정적으로 확보하게 되었음은 물론, 원자력안전위원회의 신설로 58년 원자력법 제정에 따라 설치된 원자력위원회의 기능이 분리되었으며, 방사성 폐기물 관리 사업의 추진 체제가 효율적으로 정비되었다. 12월중 공포될 예정인 개정 원자력법의 주요 내용을 중심으로 개정 취지 및 배경, 개정 내용, 앞으로의 운영 방향 등에 대해 알아본다.

원자력법 시행령 개정령

배재웅 한국원자력산업회의 1997 원자력산업 Vol.17 No.6

Carbonic Anhydrase 6 유전자의 단일염기다형성과 Phenylthiocarbamide 민감도 및 미각 장애와의 관계

배재웅,김언경,오세경,류미라,신승헌,예미경 대한이비인후과학회 2012 대한이비인후과학회지 두경부외과학 Vol.55 No.3

Background and Objectives The phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) taste sensitivity varies among individuals. Recently, it is reported that PROP taste responsiveness is associated with carbonic anhydrase 6 (CA6) gene polymorphism. The CA6 gene, a zinc metalloprotein in human saliva, is affected in taste function and might be correlated with gustatory diversity. The aim of this study was to examine whether PTC taste sensitivity and taste disorder is associated with the CA6 gene polymorphism rs2274327 (C/T), rs2274328 (A/C), and rs2274333 (A/G). Subjects and Method A total of 217 healthy normal subjects were recruited as controls, and 50 taste disorder patients were recruited as experimental group. The polymorphisms of CA6 gene were genotyped by polymerase chain reaction-restriction fragment length polymorphism analysis. All statistical analyses were calculated using the statistical package for the social science software. Haplotypes were estimated by Haploveiw and the PHASE programs. Results The CA6 gene polymorphisms showed association with taste disorder but not with PTC sensitivity (taster/nontaster). The number of control subjects carrying AA genotype of single nucleotide polymorphism rs2274328 (A/C) in the CA6 gene was higher than the number of the subjects with taste disorder (p=0.048). However, there was no association between controls and taste disorder subjects in the haplotype analysis. Conclusion These data suggest that the CA6 gene polymorphism rs2274328 could affect taste function impairment in patients with taste disorder. This observation requires a further functional study of gustin protein to clarify the association of the CA6 gene polymorphisms with the taste disorder and sensitivity.

Genetic variation of umami taste genes in Koreans

배재웅,이혜진,오세경,김소연,김언경 한국유전학회 2010 Genes & Genomics Vol.32 No.2

Umami is a pleasant savoury taste imparted by glutamate, a type of amino acid, and ribonucleotides, including inosinate and guanylate, which occur naturally in many foods including meat, fish, vegetables and dairy products. A heterodimer of TAS1R1 and TAS1R3 is known to function as umami taste receptor in humans. To address the association between genetic polymorphism of TAS1R1 / TAS1R3 genes and individual difference in umami taste sensitivity, we have examined the entire coding region of these genes using PCR-mediated direct sequencing analysis. A total of 11 SNPs were identified from 98 unrelated Korean individuals and were in Hardy-Weinberg Equilibrium. Four out of 11 SNPs were found in the exons and two of them were nonsynonymous ones. These coding SNPs (cSNPs), p.A372T in TAS1R1 and p.C757R in TAS1R3genes, were common in Koreans, so these will be useful resource for further studies to find a functional allele for individual variation to umami taste sensitivity in our population.

O,p'-DDD가 흰쥐의 신장에 미치는 독성에 관한 면역조직화학적 및 초미세형태학적 연구

배재웅,최종범,임성철,김균홍,기근홍,박동수,전호종,박규호 朝鮮大學校 附設 醫學硏究所 1989 The Medical Journal of Chosun University Vol.14 No.2

o,P'-DDD, a derivative of insecticide DDT, which reveals the toxicity and adrenostatic effet by cortisol biosynthesis in the zona fasciculata of adrenal cortex has been used for the treatment of unoperable adrenocortical carcinoma. Adverse effects of o,P'-DDD were usually dose-related and reversible. Most untoward effects include gastrointestinal disturbances, neuromuscular disorders, depression of central nervous system and skin rash but there is a few reports on its nephrotoxicities. o,P'-DDD in corn oil was administered orally to rats for 28 days to investigate its nephrotoxicity by observation of the ultrastructural changes and immunoglobulin deposition in renal glomeuli. The results obtained were as follows. 1. The ultimate destructive target of intracytoplasmic organelle in endothelium and epithelium of renal glomeruli was mitochondria. The severity of the mitochondrial alterations was dependent of the dosages of o,p'-DDD. 2. The characteristic ultrastructural changes in endothelium of glomerular capillary were swelling and detachment from underlying basement membrane. The splitting and complete separations between endothelium and basement membrane were observed in more advanced lesions by the increased dosage of administration of o,p'-DDD and basement membrane in capillary wall of renal glomeruli was irregular and partly thickened. 3. Amorphous double ring formation, electron dense deposits and multiple myelin figures in mitochondria were characteristic ultrastructural findings in the epithelium of glomeruli. 4. Ig G and Ig M depositions were clearly observed in the capillary lumen, subendothelial area and epithelial cells of proximal convoluted tubule. These depositions were more prominent by the increased of o,p'-DDD dosage. From the above results it is suggested that o,P'-DDD exhibits nephrotoxicity by mitochondrial destruction in epithelium and endothelium of glomerular capillary and the severity of mitochondrial alterations was dose dependent of o,p'-DDD.

98년도 원자력 연구개발사업 시행 계획

배재웅 한국원자력산업회의 1998 원자력산업 Vol.18 No.3

데이터 증강 방법을 이용한 정상데이터 기반 베어링 이상 진단법

배재웅(Jaewoong Bae),정원호(Wonho Jung),박용화(Yonghwa Park) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.4

최근 데이터 불균형 문제를 해결하기 위해 고장데이터 증대 연구가 활발하다. 하지만 분포 학습기반 고장데이터 증대 기법은 데이터 특성에 따라 크게 변해 고장 진단 방법론에 적용이 어렵다. 본 연구에서는 고장 데이터 없이 정상 데이터 기반 베어링 이상 진단 기법을 제안한다. 제안된 방법은 세 단계로 구성된다: (1) 정상데이터 기반 데이터 증강, (2) 컨볼루션 신경망 기반 특성인자 추출, 그리고 (3) 이상 기준치 설계. 정상데이터 기반 데이터 증강 방법은 데이터 특성에 맞춰 노이즈 추가, 진폭 변조 등을 활용한다. 특성인자 추출을 위해 ResNet 을 이용하여 정상데이터 특성인자를 추출한다. 마지막으로 추출된 특성인자를 이용하여 정상데이터와 이상데이터 간의 거리를 계산하여 이상 기준치를 선정한다. CWRU 베어링 결함 데이터셋을 이용하여 제안된 방법을 검증하였고 약 95% 이상 진단 정확도를 보였다. 본 연구는 정상데이터만을 이용하여 데이터 불균형 환경 속에서도 이상 진단이 가능함을 보였다. A research on data augmentation has been actively conducted to solve the data imbalance problem. However, data distribution learning based data augmentation method is difficult to apply to fault diagnosis methodology because fault data distribution varies under the characteristics of their dataset. This paper proposes ball bearing anomaly detection method based on normal data only. The proposed method consists of three stages: (1) data augmentation based using normal data, (2) feature extraction using convolutional neural networks, and (3) design anomality threshold. The normal data-based augmentation method utilizes adding noise, amplitude variation under consideration of the data characteristics. ResNet architecture is used for feature extraction. Finally, anomality threshold is selected by calculating the distance between normal data and abnormal data. The proposed method was verified using the CWRU bearing dataset and presented a diagnostic accuracy of about 95%. This study expects that it is possible to diagnose abnormalities even in a data imbalance using only normal data.

CoCrFeMnNi 고엔트로피합금의 이방성 및 디프드로잉 거동 연구

배재웅(J. W. Bae),문종언(J. Moon),장민지(M. J. Jang),임다미(D. Yim),서민홍(M. H. Seo),김형섭(H. S. Kim) 한국소성가공학회 2017 한국소성가공학회 학술대회 논문집 Vol.2017 No.5

CoCrFeMnNi 고엔트로피합금의 실험 및 유한요소해석을 통한 판재 성형성 평가

배재웅(J. W. Bae),문종언(J. Moon),장민지(M. J. Jang),임다미(D. Yim),서민홍(M. H. Seo),김형섭(H. S. Kim) 한국소성가공학회 2017 한국소성가공학회 학술대회 논문집 Vol.2017 No.5

미각장애와 TAS1R3 및 GNAT3 유전자의 다형성과의 연관성

Jae-Woong Bae(배재웅),Un-Kyung Kim(김언경),Tae-Jun Kwon(권태준),Su-Jin Choi(최수진),Mi-Kyung Ye(예미경) 한국생명과학회 2011 생명과학회지 Vol.21 No.3

단맛은 우리 몸에 열량을 공급하는 역할을 담당하는 중요함 감각으로 인지도가 개인마다 조금씩 다르다고 알려져 있으나, 이에 대한 분자수준의 연구는 아직 부족한 실정이다. 본 연구에서는 미각 장애에 미치는 유전적 요인에 대해 알아보고자 50명의 미각 환자 및 100명의 정상인을 대상으로 단맛 민감도 차이와 연관이 있는 TAS1R3 및 GNAT3유전자의 다형성 간의 관련성을 알아보았다. TAS1R3 유전자 rs307355 및 rs35744813의 유전자형과 대립유전자의 빈도는 미각 장애 환자군과 대조군 간에 통계적으로 유의한 차이가 있었으며, 두 다형성에 대한 일배체형을 분석한 결과, C-C 및 T-T의 두 종류만이 검출되었으며 환자군과 대조군 간의 일배체형 빈도 간에도 통계적으로 유의한 차이를 보였다. GNAT3유전자에서는 rs7792845의 유전자형 빈도가 환자군과 대조군간에 유의적인 차이를 나타냈었으나, 대립유전자빈도에서는 차이가 없었다. 이러한 연구결과는 단맛의 민감도 차이에 영향을 미치는 것으로 보고된 TAS1R3 및 GNAT3 유전자의 다형성에 대한 한국인 집단에서의 유전자형 빈도를 조사함으로써 집단유전학적 연구를 위한 기초자료를 제공하고 미각장애환자군과의 비교분석을 통해 TAS1R3 및 GNAT3유전자의 다형성이 연관성이 있을 가능성이 있음을 제시해 줌으로써 향후 미각장애를 진단하기 위한 검사시 지표로 활용될 수 있으리라 생각된다. 위에 제시한 연구결과는 향후 추가적인 샘플링을 통해 보다 많은 환자군과 대조군에 대한 추가적인 연구가 수행되어야 할 것이다. Taste sensation plays a crucial role in selecting and ingesting foods with different qualities which convey information about their nutrient content and/or safety. Sweetness is one of the five modalities in humans and serves as an energy resource for metabolism. There are reports on allelic polymorphisms which influence perception of sweetness in mice and humans. Since the influence of genetic factors on taste disorder has not been studied, we investigated the association of genetic polymorphisms in TAS1R3 and guanine nucleotide binding protein, alpha transducing 3 (GNAT3) genes and taste disorder. A total of 150 individuals composed of 50 patients with taste disorder and 100 healthy controls were recruited for the study and PCR-mediated directing sequencing method was used to genotype for two different single nucleotide polymorphisms (SNPs) - rs307355 (T>C) and rs35744813 (T>C) in the TAS1R3gene, and rs7792845 (T>C) and rs1524600 (C>T) in the the GNAT3gene. The allele and genotype frequencies of rs307355 and rs35744813 in the TAS1R3gene showed a significant association between patients with taste disorder (p=0.022 and p=0.013 in both of SNPs, respectively). In addition, the frequency of T-T haplotype in the TAS1R3gene was higher in taste disorder cases than in the controls (OR, 1.93: 95%. CI, 1.09?3.39, p=0.022). In the GNAT3, the genotype frequency of rs7792845 in the patients was also different from the controls (p=0.048), but allele frequency was not significantly associated in either group. Our result provides the frequencies of SNPs and haplotypes of the TAS1R3 and GNAT3genes for the fundamental information of nutrigenetics in perception of the taste of sweetness in the Korean population. Also, the study suggests that the allelic polymorphisms of TAS1R3 and GNAT3genes may be useful as a molecular marker for evaluating patients with taste disorder. Further studies with large samples are required to clarify our observation.