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김범석,신지훈,김기용,이용섭,김경래,태경,Kim, Bum-Suk,Shin, Ji-Hun,Kim, Ki-Yong,Lee, Yong-Seop,Kim, Kyung-Rae,Tae, Kyung 대한후두음성언어의학회 2008 대한후두음성언어의학회지 Vol.19 No.2
Background and Object: The aim of this study is to evaluate the change of patient's subjective voice handicap index (VHI) and acoustic parameters before and after laryngeal microsurgery for benign vocal cord disease. Materials and Method: We analyzed 78 patients who received laryngeal microsurgery for benign vocal cord disease from January 2004 to February 2007 retrospectively. There were 28 vocal polyp, 40 vocal nodule, 5 intracordal cyst and 5 Reinke's edema. Jitter, shimmer, harmony to noise ratio (HNR) were analyzed before surgery and 2-3months after surgery using the Doctor's speech science program. The voice handicap index introduced by the Pittsburgh Voice Center was used to examine patient's subjective change of voice quality. Results: Acoustic parameters of jitter, shimmer and HNR were improved in patients with vocal polyp and vocal nodule after surgery. The acoustic parameters were not improved in patients with Reinke's edema, statistically. Only jitter was improved significantly in patients with intracordal cyst (p<0.05). The VHI was significantly improved after surgery. The change of jitter and shimmer was significantly correlated with the change of VHI after surgery. Conclusion: The acoustic parameters and VHI were significantly improved in patients with benign vocal disease after laryngeal microsurgery.
담즙의 농축화와 산성화가 담석형성에 미치는 영향에 관한 연구
문태훈(Tai Hoon Moon),이기훈(Ki Hoon Lee),이진우(Jin Woo Lee),장동섭(Dong Seob Jang),신용운(Yong Woon shin),김영수(Young Soo Kim),김원곤(Won Gon Kim),김경래(Kyung Rae Kim) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.3
N/A Background/Aims: The most recognized function of the human gallbladder(GB) is to store bile. However, this organ is not a static reservoir. It actively modifies bile by the double process: concentration and acidification. This study was designed to compare solute composition in GB bile between patients with and without gallstones and to evaluate the effects of concentration and acidification of GB bile on cholesterol and calcium solubility. Methods: Bile was sampled directly from the GB of fifteen patients with gallstones(gallstone group) and of fourteen patients undergoing laparotomy for reasons unrelated to hepatobiliary disease(control group). In the bile, we measured electrolytes, pH, pCO, protein, cholesterol, phospholipid, and bile salt. And then, we calculated the cholesterol saturation index(CS1) by using the critical table of Carey and the CaCO saturation index(CaCO Sl) by using metbods of Rege and Moore. Results: The pH was significantly higher in gallstone group. The bile salt concentration was significantly )ower in gallstone group. In between the two groups, total protein concentration were not significantly different. The CSI and CaCO SI were higher in gallstone group, but were not significantly higher than in control group. There was no significant correlation between pH and bile salt concentration, but a significant correlation was found between pH and CaCO Sl. There was also no significant correlation between pH and bile salt concentration, CSI and bile salt concentration, and pH and CSl, respectively. Conclusions: Failure of concentration and acidification of bile was found in patients with gallstones. Concentration and acidification of bile were independent processes. Acidification of bile prevents gallstone formation by increasing calcium salt solubility. (Korean J Gastroenterol 1995;27:338 - 344)