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Multiplication and Antibody Formation of Japanese Encephalitis Virus in Snakes
기용숙,이호왕 대한미생물학회 1968 大韓微生物學會誌 Vol.3 No.1
Japanese encephalitis (JE) showes its explosive epidemicity in the temperate zone of Asia but little is on the overwintering mechanism, One of the hypotheses on the overwintering mechanism is that the virus overwinters in the hibernating animals. There has beenno report on the proliferation of JE virus (JEV) or antibody formation in snakes. The purpose of this experiment is to explore the mutual relationship between JEV and snake and to clarify whether JEV proliferates and induce entibody formation in snakes. Three species of non-poisonous common snakes were employed, precipetation test was carried out after injecting calf serum and, HI and neutralizations were done by injecting JEV into the snakes, The gamma globulin fraction of pre- and post-injection serum were compared by paper chromato- gtaphy. According to the results precipitating antibody reaction to calf serum could be observed only at 4℃. It was failed to demonstrate HI antibody formation but neutralization antibody could be detected in one of the9 snakes. Although antibody could not be detected in test-tube, the result of paper chromatography shows the remarkable increase of gamma plobulin fraction after the injection. Above result are strongly indicating the antibodty formation in the snakes.