한국 남성 알코올의존 환자에서의 COMT 유전자 다형성

권용실(Yong-Sil Kweon),이해국(Hae-Kook Lee),이정태(Chung Tai Lee):배치운(Chi-Un Pae) 한국중독정신의학회 2003 중독정신의학 Vol.7 No.1

Catechol-O-Methyltransferase (COMT) is an enzyme which play a crucial role in the metabolism of dopamine. It has been suggested that COMT provide molecular role in development of alcohol dependence because of its genetic polymorphism associated with 3-4 fold variation in enzymatic activity. We carried out an association study to verify the relationship between COMT gene polymorphism and alcohol dependence with violent behavior in Korean population. Ninety seven (97) male alcoholics and 94 male normal controls who did not have history of psychiatric illness were enrolled in this study. After amplifying COMT genes by polymerase chain reaction and assessed genotype and allele by Restriction Frag-ment Length Polymorphism (RFLP). Distribution of COMT genotype and allele frequencies between patients and controls was not significantly different. However, the differences between violent group and nonviolent group were significant in frequencies of COMT genotype (χ 2 =7.977, df=2, p=0.019) and allele (χ 2 = 6.832, df=1, p=0.012). Additionally, the differences between nonviolent groups and controls were significant in frequencies of COMT allele (χ 2 =4.481, df=1, p=0.040). This result suggest that COMT gene polymorphism is not associated with the development of alcohol dependence, but may affect a susceptibility to clinical heterogeneity of alcohol dependence, at least in the Korean population.

한국형 비행 청소년 정신병리 선별척도인 MAYSI-2K(Massachusettes Youth Screening Instrument-2Korean)의 표준화를 위한 예비연구

권용실(Yong Sil Kweon),이지현(Ji-Hyun Yi),이해국(Hae Kook Lee),이정태(Chung Tai Lee),김선경(Sun Kyung Kim) 대한소아청소년정신의학회 2003 소아청소년정신의학 Vol.14 No.2

주의산만과 과잉운동을 주소로 하는 정신과 내원 아동들의 임상 평가

권용실(Yong Sil Kweon) 대한소아청소년정신의학회 2002 소아청소년정신의학 Vol.13 No.1

알코올 금단 환자에서 금단 섬망 발생의 위험요인

권용실(Yong-Sil Kweon),이해국(Hae-Kook Lee),이정태(Chung Tai Lee),이지현(Ji-Hyun Yi) 한국중독정신의학회 2003 중독정신의학 Vol.7 No.2

Alcohol withdrawal syndrome occurs in alcohol dependent patients who discontinue or decrease their alcohol consumption. Delirium tremens, is not a frequent, but serious complication of alcohol withdrawal in patients with alcohol dependence. To identify clinical characteristics associated with development of delirium tremens, we performed retrospective case-control study among discharged with diagnosis of alcohol dependence. Seventy six patients discharged between June 2002 and June 2003 were enrolled to this study. Among 76 subjects, 29 patients developed delirium tremens during hospitalization. Bivariate analysis indicated that age, duration of current episode, days since last drinks, comorbid medical illness and presence of brain vulnerability were associated with development of delirium tremens. In a stepwise multiple regression model, four risk factor were significantly correlated with the development of delirium tremens:days since last drinks, brain vulnerability, age, pulse rate (Percentage correct=82.9%). Prediction of alcohol withdrawal delirium by evaluation of several readily available clinical variables can be useful in effective management of alcohol withdrawal patients.

정신분열병의 미세신체기형과 음성증상

전태연(Tae Youn Jun),도규영(Kyu Young Toh),김석범(Seok Beom Kim),권용실(Yong Sil Kweon) 한국정신병리진단분류학회 1998 精神病理學 Vol.7 No.2

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일 도시지역 위험음주의 유병률과 관련요인에 관한 연구

조중범(Joong-Bum Jo),이정태(Chung-Tai Lee),권용실(Yong-Sil Kweon),이경욱(Kyoung-Uk Lee),이해국(Hae-Kook Lee),조선진(Sun-Jin Jo),김한오(Hano Kim) 한국중독정신의학회 2011 중독정신의학 Vol.15 No.2

Objective : The aim of this study was to estimate the prevalence of hazardous drinking in a representative community sample of Seoul, Korea and to assess the sociodemographic and psycho-logical factors associated with hazardous drinking. Methods : Sociodemographic data, scores for AUDIT-K and other psycho-logical screening instruments were collected from a sample of 798 individuals from one of the municipal areas of Seoul. Recruitment was done based on a stratified-multistage-cluster sampling. Results : The 12-month prevalence of hazardous drinking was 36.6% (60.5% of males and 18.5% of females). Considering the sample as a whole, multiple logistic regression analysis showed that the risk factors of hazardous drinking were male (adjusted OR=7.96, 95% CI 5.36-11.83), young age (18-29 years old, adjusted OR=3.84, 95% CI 1.81-8.17) and high stress level (adjusted OR=1.72, 95% CI 1.19-2.49). Among males, the widowed/separated/divorced (adjusted OR=5.76, 95% CI 1.17-28.27) and high stress level (adjusted OR=1.68, 95% CI 1.03-2.75) were significant risk factors for hazardous drinking. In the case of females, young age (adjusted OR=6.22, 95% CI 2.04-18.94), high stress level (adjusted OR=2.01, 95% CI 1.12-3.61) and low resilience (adjusted OR=2.15, 95% CI 1.19-3.89) were risk factors for hazardous drinking. Conclusion : The prevalence of hazardous drinking in Seoul in this study was demonstrated to be one of the highest in the world. Our results also suggested that hazardous drinking was further associated with sociodemographic factors than with psychological factors. Preventive measures and intervention pro-grams should be tailored to males, young females and people with stressful life events to reduce the hazardous drinking in the community.

알코올의존 환자 부인의 정신병리와 공동의존 및 스트레스 대응전략

전원희(Won-Hee Jun):양 수(Soo Yang),이정태(Chung-Tai Lee),권용실(Yong-Sil Kweon),이경욱(Kyoung-Uk Lee):이해국(Hae-Kook Lee):방승규(Seung-Kyu Bang),정규인(Kyoo-In Chung) 한국중독정신의학회 2004 중독정신의학 Vol.8 No.2

Objectives:This study was designed to compare psychopathologies, codependence and stress scoping strategy for assisting the understanding of psychological mechanism and future intervention modalities. Methods:One hundred and two wives of alcohol dependence patients who were recruited from the department of psychiatry in five general hospitals and one hundred and three healthy subjects participated in this study. The authors used SCL-90-R (Korean Symptom Check List-90-Revision) for the measurement of psychopathologies, CAI (Codependency Assessment Inventory) for codependence and WCSS (Weisman Coping Strategy Scale) for coping ability. Results: 1) Six symptom dimension scores (somatization, depression, anxiety, hostility, phobic anxiety, additional items and total) in SCL-90-R and CAI scores of the patients’ wives group were significantly higher than those of the control group. 2) In the patients’ wives group, there were significantly positive correlations between seven symptom dimension scores (somatization, obsessive-compulsive, depression, anxiety, hostility, additional items and total) in SCL-90-R and CAI score. 3) In the patients’ wives group, WCSS showed compliance, intellectualism and shared concern to be higher in frequency. Externalization and flexibility were lower in frequency. 4) In the patients’ wives group, depression symptom dimension scores in SCL-90-R were significantly lower in subgroups that used intellectualism, shared concern, isolation and compliance and was significantly higher in subgroups using suppression. 5) In the patients’ wives group, anxiety symptom dimension scores in SCL-90-R were significantly lower in subgroups that used confrontation and compliance. 6) In the patients’ wives group, CAI scores were significantly lower in subgroups that used intellectualism, shared concern, confrontation and was significantly higher in subgroups using isolation. Conclusion:Wives of alcohol dependence patients showed psychopathological problems, higher codependence, and they used relatively positive coping strategies. This suggests that appropriate intervention modalities that improve coping strategies having positive influence on psychopathologies and codependence are required.

효율적인 적정음주기준의 개발

이해국(Hae-Kook Lee),이정태(Chung-Tai Lee),권용실(Yong-Sil Kweon) 한국중독정신의학회 2006 중독정신의학 Vol.10 No.2

Alcohol consumption has been associated with favorable as well as adverse health effects. Alcohol is an addictive substance, therefore some individuals who drink alcoholic beverages develope alcoholism and others experience various alcohol problems. We have a permissive cultural background to alcohol drinking, so the prevalence of alcoholism and alcohol problems are generally high. Therefore, it is needed to develope effective guideline for moderate drinking to prevent drinking related harm. Many countries have moderate drinking guidelines to prevent heavy drinking and drinking related harm. Generally, guidelines recommend 35-50 gram of alcohol as a tolerable level of daily consumption. But, developing and application of guidelines are very carefully considered because even small amount of alcohol can cause various risk by individual’s vulnerabilities and different sociocultural background. And, it is not recommended that the abstinences start drinking to obtain health effect of moderate drinking. We reviewed some drinking guidelines of other countries, and suggested several principles of conducting moderate drinking guidelines. First, considering our permissive legal and cultural environment, we need a more strict guidelines. Second, to developing effective drinking guidelines, the efforts to increase public awareness of drinking related harm need to be conducted. Third, the intensive researches which is related to pharmcokinetics and toxic effects of alcohol in Korean should be followed.

알츠하이머병에서 우울 증상과 고혈압의 관계

김규동(Kyu-Dong Kim),이승엽(Seung-Yup Lee),이해국(Hae-Kook Lee),이경욱(Kyoung-Uk Lee),권용실( Yong-Sil Kweon),이정태(Chung-Tai Lee) 대한노인정신의학회 2017 노인정신의학 Vol.21 No.2

Objective:To explore the effect of vascular risk factors to the depressive symptom in Alzheimer’s disease (AD). Methods:Retrospective chart reviews were performed for the patients, who underwent comprehensive neuropsychiatric assessment in the geriatric psychiatric clinic in the period between May of 2015 and January of 2017. Patients with moderate to severe stage of AD, neurological comorbidities and major psychiatric disorders were excluded to minimize the confounding factors. Sixty five newly diagnosed early AD patients were included and bisected by the cutoff point of 5 in the short version of the Geriatric Depression Scale. Comparisons were done between two groups for vascular risk factors and other relevant clinic-demographic variables. Binary logistic regression analysis was additionally performed to estimate the effect of hypertension to the depressive symptoms. Results:Among the investigated vascular risk factors, hypertension was associated with depressive symptom in the early AD patients. In the logistic regression, odd ratio of hypertension for depression was 4.34 (95% confidence interval 1.47-12.79). Conclusion:Depressive symptoms in the AD patients were associated with hypertension. Therefore, managing this vascular factor in the middle age may not only decrease the risk for neurovascular disorders, but also provide additional benefits in curtailing depression in AD.

청소년 자살자에 대한 심리적 부검 방법론에 대한 고찰

권호인(Hoin Kwon),김란(Ran Kim),방수영(Soo-Young Bhang),홍현주(Hyun Ju Hong),권용실(Yong Sil Kweon) 대한소아청소년정신의학회 2014 소아청소년정신의학 Vol.25 No.3

Recently, local governments and suicide prevention centers have been trying to implement psychological autopsy. This effort has focused on adult suicide so far ; however, there are some difficulties in its application to adolescent suicide. Therefore, in this study, psychological autopsy studies of Korea were reviewed, and a methodology for adolescents’ psychological autopsy was suggested. For the effective performance of the psychological autopsy in adolescent suicide, cooperation with each area of the government and implementation of bodies is necessary. In addition, the central system, which disseminates the standardized interview to the community and manages the data nationwide, should be prepared. Also, in order to improve the accuracy of diagnosis and to obtain various types of information, a structured interview should be adopted as the psychological autopsy, as well as considering the use of social media. Investigation of specific risk factors for adolescent suicide through psychological autopsy can enable determination of the intervention point for effective suicide prevention.