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구현경 ( Hyeon Kyoung Koo ),김서윤 ( Seo Yun Kim ),박성수 ( Sung Soo Park ),이연주 ( Yeon Joo Lee ),이지연 ( Ji Yeon Lee ),정진행 ( Jin Haeng Chung ),이재호 ( Jae Ho Lee ),이춘택 ( Choon Taek Lee ),윤호일 ( Ho Il Yoon ) 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.69 No.3
Nodular lymphoid hyperplasia is a very rare benign disease and usually shows consolidation on chest X-ray with symptoms of pneumonia due to the proliferation of lymphoid cells in the lung parenchyma. It is common for patients to be diagnosed with pneumonia and treated with antibiotics, but patients often enter a cycle of repeated improvement, followed by aggravation of symptoms. At this point, surgical diagnostic tools are considered in order to differentiate between malignant disease and interstitial lung disease. Here, we report 2 cases of patients with nodular lymphoid hyperplasia and review the associated references.
폐결핵으로 치료 중 범혈구감소증으로 발현한 전신홍반루푸스
배원 ( Won Bae ),강지은 ( Jieun Kang ),박소희 ( So-hee Park ),강형구 ( Hyung Koo Kang ),구현경 ( Hyeon-kyoung Koo ),박혜경 ( Hye Kyeong Park ),이성순 ( Sung-soon Lee ) 대한내과학회 2021 대한내과학회지 Vol.96 No.2
결핵약은 혈액장애를 비롯한 많은 부작용을 유발할 수 있다. 그렇지만 결핵약에 의한 범혈구감소증은 매우 드물다. 해당 환자에서 결핵약을 복용하던 중 지속되는 범혈구감소증에 대해 약제 관련 부작용 가능성을 가장 먼저 감별하고자 하였으나, 약제와 무관한 다른 질환의 발현으로 확인되었다. 가장 가능성이 높은 원인 질환을 먼저 고려하는 것이 중요하지만, 환자가 여러 질환을 가지고 있을 수 있다는 점을 항상 명심해야 한다. A 49-year-old Chinese woman presented to Ilsan Paik Hospital emergency department with fever and general weakness. Chest computed tomography revealed cavity and peribronchial nodules and consolidation in the right upper lobe. A diagnosis of suspected active tuberculosis was made. A review of the patient’s medication prescribed at another hospital indicated that she had been taking antituberculosis medication for several months. Initially, the patient had anemia and mild thrombocytopenia. In addition, she developed leukopenia and her thrombocytopenia worsened. After discontinuing the antituberculosis medication, her pancytopenia initially improved, but was aggravated again after starting on antituberculosis drugs. Despite discontinuing the antituberculosis medication again, her pancytopenia progressed. As she had a high anti-nuclear antibody titer, another systemic disease was suspected. She was diagnosed with systemic lupus erythematosus and her leukopenia and thrombocytopenia improved after initiation of treatment with systemic steroids and antimalarial drugs. (Korean J Med 2021;96:147-151)