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구태규 ( Tae Kyu Ku ),유일수 ( Il Sou Yoo ),박안나 ( An Na Park ) 한국미용학회 2014 한국미용학회지 Vol.20 No.5
In this study was to examine the applicability of mango (MangiferaindicaL.) leaf extract to cosmetics a composition based on its antioxidant activity. Extracted with ethanol and water to obtain a 50% concentration of mango leaf extract (0.4, 2, 10, 50 mg/ml) as mango leaf collected in Jeju Island, Korea. In 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical assay, lower concentrations of mango leaf extract resulted in a dose-dependent increase in antioxidant activity compared to the synthetic antioxidant butylated hydroxytoluene (BHT). Total polyphenol and flavonoid contents were highest in the 50 mg/mL mango leaf extract. Cell viability and cytotoxicity were assessed in RAW 264.7 cells by ROS production, macrophages were exposed to various concentrations (10, 25, and 50 μL) of mango leaf extract. Reduced DCF fluorescence intensities indicating stronger antioxidant activities were observed in a mango leaf extract concentration-dependent manner. Nitrite scavenging activity also increased with higher concentrations of mango leaf extract, thus demonstrating the ability of mango leaf extract to inhibit nitrosamine production. Based on these results, mango leaves have excellent antioxidant activity and are safe to be incorporated and used as a component of cosmetics a composition.
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Hot carrier 개선을 위한 N2 이온주입에 따른 MOSFET의 Digital/Analog 특성 분석
구태규(Taegyu Goo),한인식(Inshik Han),유욱상(Ooksang Yoo),주한수(Hansoo Joo),최원호(Wonho Choi),손영환(Younghwan Son),이정환(Jeonghwan Lee),강영석(Younseok Kang),임민규(Mingyu Lim),최성욱(Seongwook Chio),이가원(Gawon Lee),왕진석(Jinseok 대한전자공학회 2006 대한전자공학회 학술대회 Vol.2006 No.11
In this paper, we investigated the performance and reliability of the device as formatting LDD(Lightly Doped Drain) with additional N₂ implant process. In case of the N₂ implantation, the TED(Transient Enhanced Diffusion) of boron is suppressed in channel regime and the drain current increased. But hot carrier lifetime is improved. Also, we investigated a change of the effective channel length using CP(Charge Pumping) current method and the analog performance is compared to evaluate DC gain and Rout according N₂ implantation. However, the N₂ implantation did not affect at analog performance. But the drain current at the normalized threshold voltage is degraded in digital performance. Therefore, we proved that the reliability can be improved without degrading Rout performance. The important Input/Output(IO) device in the analog performance is partially adapted for nano CMOS technology.
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피부미용이 관광객의 만족도와 재방문에 미치는 영향 -일본인 여성 관광객을 중심으로-
구태규 ( Tae Kyu Ku ),변정우 ( Jeoung Woo Byun ),박안나 ( An Na Park ) 한국미용학회 2010 한국미용학회지 Vol.16 No.3
According to the result of a public-opinion poll, conducted by AC Nielsen, institution for market survey, and intended for men and women of 47 countries, it was indicated that one-third of them spent money, for investing in themselves, on skin care more than on the other things. Skin care, one of the subjects for SIT (Special Interest Tourism), despite one type of higher value-added businesses in developed countries, has missed the possibility of becoming a product for tourism, bound in public health law and interested parties` demands. We hope that resources in Korea could be arranged and utilized, based on abundant andcompetent power of men; we aim at promoting tourists` revisit, by making them satisfied with a Korean new product on skin care, through investigations and researches on how this product affects Korean tourism. This research investigated the difference of tourist`s satisfaction on the use of skin care, targeting Japanese women tourists who visited Korea, by analyzing people who experienced skin care and the others who didn`t, in order to know whether skin care is appropriate as a product for tourism in the internationalized world. It revealed: all facilities and related services on skin care could raise tourists` satisfaction and their intention for revisit; people experiencing a skin treatment in korea wanted to revisit Korean and experience it again. The Korean tourism will have another chance for further development, if skin care is able to be specialized in promoting tourists` satisfaction and their intention for revisit.
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박안나,구태규,김경선,이동원,김상진 한국유화학회 2015 한국응용과학기술학회지 Vol.32 No.4
천마를 다양한 용매(물, 에탄올 및 70%) 및 다양한 농도 (0.725, 1.25, 2.5 및 5 mg/mL)로 추출하고 추출된 물질을 젖산균과 유용미생물(Effective Microorganisms)로 발효시킨 다음, 이들 물질들 이 화장품 소재로 활용 가능한가를 확인하였다. 물, 에탄올 및 70% 에탄올로 추출한 물질들을 각각 0.725, 1.25, 2.5 및 5 mg/mL 농도에서 실험한 결과, flavonoid, polyphenol 및 DPPH free radical scavenger 등과 같은 항산화물질은 에탄올 추출물에 가장 많이 함유되어 있었고, DPPH radical 소거능 은 유용미생물로 발효시킨 천마를 에탄올로 추출한 경우 1.25 mg/mL에서 27.08 ± 0.5%이었으나 2.5 mg/mL에서는 27.08 ± 0.5%로 증가하였다. 미백 활성을 측정할 수 있는 tyrosinase 활성 저해 실험에 서는 EtOH 추출물을 젖산균으로 발효시켰을 때 가장 저해 효과가 우수하였고(0.725 mg/mL에서 39.1 ± 0.4%, 2.5 mg/mL에서 62.8 ± 1.5%), RAW 264.7 Cells을 이용한 세포 생존율 실험 결과 물, EtOH, 70% EtOH 추출물과 이들의 발효 물질 모두 85%이상의 세포 생존율을 나타내 세포의 염증에 대한 안정성을 확인하였다. ROS 생성으로 인한 항산화 실험에서는 양성 대조군으로 RAW 264.7 cells 을 lipopolysaccharide로 자극시켜 활성화된 세포에 비발효와 발효에 따른 추출물을 농도별로 처리하였 을 때 유효미생물로 발효시켰을 경우가 가장 항산화성이 높은 것으로 확인하였다. 이상과 같은 연구결과 천마 추출 및 발효 물질은 화장품용 항산화제, tyrosinase 활성 저해제 및 항염증제로 사용될 수 있음을 알았다. This study was conducted to determine the feasibility of using Gastrodia elata Blume as a cosmetic raw material by investigating the physiological activities of its extracts, varying the concentration, solvent, and fermentation method (non-fermentation and fermentation using lactic acid bacteria and effective microorganisms). Of the extracts in three different solvents—water, EtOH, and 70% EtOH—at four different concentrations (0.725, 1.25, 2.5, and 5 mg/mL), the EtOH extracts demonstrated the highest contents of antioxidants (flavonoids, polyphenols, and DPPH free radical scavengers). The DPPH free radical scavenging activity in the EtOH extracts of EM-fermented Gastrodia elata Blume increased from 27.08 ± 0.5% at 1.25 mg/mL to 35.89 ± 0.8% at 2.5 mg/mL. The tyrosinase inhibitory activity test was performed to measure skin-whitening capacity and revealed the LB-fermented EtOH extracts to be the most efficacious (39.1 ± 0.4% at 0.725 mg/mL, 62.8 ± 1.5% at 2.5 mg/mL). Viability was found to exceed 85% in RAW 264.7 cells treated with all extracts (water, EtOH, 70% EtOH at 10, 25, 50 μL, fermented and non-fermented), thus proving that Gastrodia elata Blume extracts do not cause inflammation. When RAW 264.7 cells were stimulated with lipopolysaccharide as positive controls under the same conditions to determine the antioxidant activity in the presence of reactive oxygen species (ROS), EM-fermentation was found to impart excellent antioxidant capacity. This study verified the physiological activities of fermented Gastrodia elata Blume extracts that are best suited for cosmetic ingredients, such as antioxidants, tyrosinase inhibitors and anti-inflammatory agents.
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