서울시내 건축물 석면해체·제거 사업장 및 주변에서의공기 중 석면농도 특성에 관한 연구

이진효(Jin Hyo Lee),이수현(Su Hyun Lee),김정연(Jeong Yeun Kim),김지희(Ji Hui Kim),정숙녀(Sook Nye Chung),김진아(Jin A Kim),김익수(Ik Soo Kim),어수미(Soo Mi Eo),정권(Kweon Jung),이진숙(Jin Sook Lee),구자용(Ja Yong Koo) 大韓環境工學會 2014 대한환경공학회지 Vol.36 No.6

본 연구에서는 석면해체.제거작업에 따른 작업자 및 주변 환경에 미치는 영향 등을 파악하기 위해 서울시내 건축물석면해체.제거 사업장을 대상으로 공기 중 석면농도를 조사하고, 측정결과가 「석면안전관리법」에서 명시된 사업장 주변의석면배출허용기준에 적합한지를 살펴보았다. 서울시내 총 37개소 석면해체.제거 사업장에서 총 288개의 공기 중 시료를 분석하였으며, 전체 288개 시료 중 101개 시료에서(35%) 검출한계(7 fiber/mm2) 이하로 나타났다. 이 때 전체 공기 중 석면농도평균값은 0.003±0.002 f/cc로(최대 0.013 f/cc) 대부분의 공기 중 석면농도는 「석면안전관리법」에서 명시된 사업장 주변의 석면배출허용기준 0.01 f/cc 이하로 나타나 서울시내 건축물 석면해체.제거 사업장에서의 석면 노출가능성은 우려할 수준이아닌 것으로 판단된다. 채취지점별로 살펴보면, 부지경계선(148개), 위생설비입구(25개), 작업장주변(실내)(7개), 작업장주변(실외)(11개)에 대한 공기 중 석면농도 결과, 각각 53개(36%), 5개(20%), 1개(14%), 4개(36%) 시료에서 검출한계 이하로 나타났으며 평균농도는 각각 0.002±0.002 f/cc(최대 0.008 f/cc), 0.004±0.002 f/cc(최대 0.009 f/cc), 0.004±0.002 f/cc(최대 0.007 f/cc),0.004±0.002 f/cc로(최대 0.008 f/cc) 나타났다. 또한 음압기(13개), 폐기물보관지점(27개), 폐기물반출구(9개), 거주자주거지역(48개)에 대한 공기 중 석면농도 결과, 각각 3개(23%), 8개(30%), 2개(22%), 25개(52%) 시료에서 검출한계 이하로 나타났으며평균농도는 각각 0.004±0.002 f/cc(최대 0.009 f/cc), 0.005±0.004 f/cc(최대 0.013 f/cc), 0.005±0.003 f/cc(최대 0.009 f/cc),0.003±0.002 f/cc로(최대 0.009 f/cc) 나타났다. This study is purposed to measure airborne asbestos concentrations at demolition sites and surrounding areas of asbestoscontaining buildings in Seoul and examine whether the measurement results correspond with allowable exhaust standard for asbestosof the Asbestos Safety Control Act. The airborne asbestos concentrations for 37 sites were below the detection limit (7 fiber/mm2)in 101 (35%) out of 288 samples. The whole average airborne asbestos concentration in 37 sites was 0.003±0.002 f/cc (max 0.0013f/cc) and almost the whole airborne asbestos concentrations were satisfied with allowable exhaust standard for asbestos, 0.01 f/cc, ofthe Asbestos Safety Control Act. So possibility of asbestos exposure is not yet a major concern at current levels for sites demolishedof asbestos containing buildings in Seoul. Looking at each sampling point, the average airborne asbestos concentrations in boundaryline of site, entrance of sanitation, around the workplace (in), around the workplace (out), negative pressure units, storage area forwaste, outlet for waste and residential area of residents were respectively 0.002±0.002 f/cc, 0.004±0.002 f/cc, 0.004±0.002 f/cc,0.004±0.002 f/cc, 0.004±0.002 f/cc, 0.005±0.004 f/cc, 0.005±0.003 f/cc and 0.003±0.002 f/cc. As a result, all sampling points ofstudy were satisfied with allowable exhaust standard for asbestos, 0.01 f/cc, of the Asbestos Safety Control Act.

위암환자의 혈청 CEA , CA19 - 9 및 AFP 에 관한 연구

최환준(Hwan Jun Choi),이신호(Shin Ho Lee),박무인(Moo In Park),우인기(In Ki Woo),김병립(Byung Lip Kim),최종수(Jong Soo Choi),지상근(Sang Geun Ghi),구자영(Ja Young Koo),정숙금(Sook Kum Jeong),허만하(Man Ha Huh) 대한내과학회 1994 대한내과학회지 Vol.47 No.5

N/A Objectives: For the diagnosis and evaluation of gastric cancer, various methods including upper GI series, endoscopy, ultrasound, CAT scan are used with serum tumor markers, especially CEA, CA19-9 and AFP. Although many studies were done to evaluate the clinical usefulness of serum tumor markers for the diagnosis and management of gastrointestinal cancer, the studies which was done in depth on gastric cancer alone were few. In this study we, therefore, evaluated clinical significance of serum CEA, CA19-9 and AFP of 712 gastric cancer patients for the diagnosis and management of gastric cancer. Methods: Serum levels of CEA, CA19-9 and AFP were measured in 712 eases of gastric cancer including 346 operative cases to evaluate the clinical usefulness of these markers for the diagnosis and management of gastric cancer. The cutoff level of serum CEA, CA19-9 and AFP were 10 ng/ml, 37 U/ml and 20 ng/ml, respectively. The serum levels were correlated with the stage, the location, the gross type, the depth of invasion, the nodal and distant metastasis. AFP-positive cases were analysed seperately and immunohistochemical staining was done to asses the presence of AFP, EGF and TGF β in the cancer tissue. Results: 1) Overall positivity of CEA, CA19-9 and AFP was 27.8% (198 cases), 32.7%; (233 cases) and 5.6% (30 cases/540 cases), respectively. 2) There was no difference in the positivity of serum CEA and CA19-9 according to locations and gross types of the cancer, but significant (p<0.05) difference in the positivity of serum CEA and CA19-9 was noted between cases of early gastric cancer (3.0% and 0.0%) and advanced gastric cancer (19.2% and 30.4%). 3) The positivity of serum CEA of stage IV (35.5%) was significantly (p<0.05) higher than that of stage II (4.4%), stage IIIA (10.2%) and stage IIIB (15.1%). Furthermore, 70.4% of the cases of positive serum CEA belonged to stage IV. On the other hand, serum CA19-9 positivity was 6.7%, 23.7%, 34.0% and 45.5% for the stage II, stage IIIA, stage IIIB and stage IU, respectively, showing significant difference between stage II and stage IIIA, IIIB, IV and between stage IIIA and stage IV (p<0.05). 4) The cases with perigastric tissue invasion (T₄) marked highest positivity (26.6%) of serum CEA level, but there was no correlation between positivity of serum CEA and depth of invasion. In the case of CA19-9, serum positivity v as 2.9%, l.5%, 29.3% and 39.8% for T₁, T₂, T₃, and T₄, respectively, showing relatively good correlation between CA19-9 positivity and depth of invasion. 5) The positivity of serum CEA and CA19-9 of NO group (3.0% and 9.9%, respectively) was significantly (p<0.05) lower than those of N2 group (15.7% and 24.5%, respectively). The positivity of N2 group (29.4% and 42.4%, respectively) was significantly higher than that of NO group and N2 gorup (p<0.05). 6) In the cases of metastasis present, CEA and CA19-9 positivity was 42.5% and 49.3%, respectively, which was significantly (p<0.05) higher than that of metastasis-negative cases (7.6g and 17.39, respectively). Between sites of metastasis, there was no difference in the positivity of CEA and CA19-9. 7) CEA and CA19-9 positivity in AFP-positive gastric cancer was 66.7%, 46.7%, respectively, and 83.3%, of cases belonged to stage IV, while distant metastasis was present in 73.3% of cases, among which liver was the most common site (43.3%). The AFP was demonstrated in the cancer tissue of 21 cases (91.3%) of 23 cases on which immunohistochemical staining was done. TGF β and EGF were present in 17 cases (81.0%) and 9 cases (42.9%) of AFP-positive 21 cases. Conclusion: Serum CEA and CA19-9 was not useful as a screening test in the diagnosis of gastric cancer, but may be useful in differentiating between early and advanced cases, in determining depth of invasion, and in detecting nodal and distant metastasis. Especially, CA19-9 was superior to CEA in stage grouping and in determining depth of invasion. AFP may be of some help in pred

신기능 저하 환자의 조영제 신독성 예방을 위한 N-acetylcysteine 복용과 수액요법의 비교

서정숙 ( Jeong Sook Seo ),전혜정 ( Hae Jung Jun ),구호석 ( Ho Seok Koo ),이원동 ( Won Dong Lee ),강선우 ( Sun Woo Kang ),김영훈 ( Yeong Hoon Kim ),김양욱 ( Yang Wook Kim ),이정녀 ( Jeong Nyeo Lee ),박성한 ( Sung Han Park ),이준식 대한내과학회 2007 대한내과학회지 Vol.73 No.4

목적: 조영제로 인한 신부전(contrast induced nephropathy, CIN)은 신기능 저하 환자에게 있어 급성신부전의 중요한 원인 중 하나이다. 이러한 CIN의 예방 방법으로서 N-acetylcysteine (NAC)와 수액 공급 병합요법이 효과적으로 알려져 있다. 그러나 단독 수액요법 또한 예방효과가 있다고 보고되고 있다. 이에 저자들은 신기능저하 환자에게 있어 단독 경구 NAC 투여가 단독 수액요법과 비교하여 CIN의 예방에 유사한 효과가 있는지, 혈관 확장제인 nitric oxide의 요중 배설에 차이가 있는지를 비교함으로써 향후 충분한 수액요법을 하기 힘든 경우, 경구 NAC 투여만으로 CIN의 예방이 가능한가를 알아보기 위해 본 연구를 시행하였다. 방법: 비이온성, 저삼투성 조영제를 이용한 방사선학적 검사(복부 컴퓨터 단층 촬영 또는 관상동맥 조영술)가 필요한 27명의 신기능 저하 환자를 대상으로 하였다. CIN의 정의는 급성 신부전이 발생할 특별한 원인 없이 조영제 사용 전에 비교하여 사용 후 48시간 내에 혈청크레아티닌이 0.5 mg/dL 이상 증가하는 것으로 정의하였다. 이 환자들 중 11명은 NAC 600 mg을 하루 두 번 복용시켰고, 16명은 0.45% saline을 1 mL/kg/Hr의 비율로 조영제를 투여하기 전 12시간 동안과 조영제 사용 후 12시간 동안 투여하였다. 환자들을 대상으로 조영제를 투여하기 전과 투여 후의 혈청 크레아티닌, FENa, 크레아티닌 청소율을 측정하였다. 그리고 NAC 투여한 5명과 수액 군의 10명을 대상으로 조영제 사용 전과 사용 48시간 후의 요중 nitrite를 측정하였다. 결과: 사용한 조영제의 평균 양(100.9±54.8 vs 114.7±38 mL; p=0.43) 및 기본 혈청 크레아티닌의 수치는 양 군에서 차이가 없었다(2.31±1.59 vs 2.18±1.4 mg/dL; p=0.98). CIN의 발생 빈도는 NAC군과 수액요법군에서 18.2%와 12.5%로 두 군 간의 유의할만한 차이가 없었다(p=1.0). 또한 조영제 사용 전 혈청 크레아티닌이 CIN발생에 가장 중요한 위험 요소였다. 뇨 nitrite/크레아티닌 비(μmol/mg)는 NAC군에서는 투여 전, 후 각각 1.26±0.57, 1.43±0.64였고, 수액요법군에서는 0.80±0.40, 1.18±0.60로 두 군 간의 유의한 차이는 없었다. 조영제 노출 후 수액용법군에 비해 NAC군에서 FENa는 증가하였다(p=0.04). 결론: 단독 경구 NAC 투여 역시 CIN의 예방에 효과적이었다. 이에 따라 수액투여가 금기시 되는 신기능 저하 환자에 있어 CIN의 예방에 NAC 단독요법이 효과적일 것으로 사료된다. Background: Contrast induced nephropathy (CIN) is an important cause of acute renal failure in patients with renal dysfunction. We investigated whether oral NAC alone was sufficient to prevent CIN to the same extent as hydration in patients with renal dysfunction, and whether these treatments resulted in diffierences in the urinary excretion of nitric oxide, a vasodilator. Methods: A total of 27 patients with renal dysfunction, who underwent radiographic examination with nonionic and low osmolar contrast, were randomly assigned to receive either NAC (600 mg orally twice daily; N=11) or 0.45% saline hydration (1 mL/kg/Hr; N=16) 12 hours prior to and 12 hours after the contrast procedure. We measured serum creatinine (sCr), fractional excretion of sodium (FENa), creatinine clearance (CCr), and urinary nitrite before and after contrast administration. Results: The mean volume of contrast used was similar in the two groups (100.9±54.8 mL vs 114.7±38 mL; p=0.43), as was baseline sCr in the two groups (2.31±1.59 mg/dL vs 2.18±1.41 mg/dL; p=0.98). Treatment did not significantly affect the incidence of CIN, with 18.2% and 12.5% in the NAC group and hydration group, respectively (p=1.0). The urinary nitrite/creatinine ratio (μmol/mg) was 1.26±0.57 and 1.43±0.64 at baseline and 48 hours after contrast exposure in the NAC group, respectively, and 0.80±0.40 and 1.18±0.60 in the hydration group, respectively, which were not significantly different. FENa increased significantly after contrast exposure in the NAC group compared with hydration group (p=0.04) Conclusions: NAC alone may prevent CIN. When bolus hydration is contraindicated in patients with renal dysfunction, administration of NAC alone may be sufficient.(Korean J Med 73:361-367, 2007)

인공씨감자의 Greening이 Dry Matter함량, 경도, 저장력 및 발아율에 미치는 영향

박세원(Park Se-Won),정혁(Joung Hyouk),구정숙(Koo Jeong-Sook),전재흥(Jeon Jae-Heung),김현순(Kim Hyun-Soon) 한국원예학회 1991 한국원예학회 학술발표요지 Vol.9 No.2

에틸렌흡수제 Ca⁺⁺처리가 감자조직배양시 투명화현상에 미치는 효과

박세원(Park Se-Won),정혁(Joung Hyouk),구정숙(Koo Jeong-Sook),전재흥(Jeon Jae-Heung) 한국원예학회 1991 한국원예학회 학술발표요지 Vol.9 No.1

인공씨감자의 크기가 Dry Matter와 당함량 및 발아율에 미치는 영향

박세원(Park Se-Won),정혁(Joung Hyouk),구정숙(Koo Jeong-Sook),천재흥(Jeon Jae-Heung),김현순(Kim Hyun-Soon) 한국원예학회 1991 한국원예학회 학술발표요지 Vol.9 No.2

수확된 인공씨감자의 성숙도가 품질, 저장 및 발아에 미치는 영향

박세원(Park Se-Won),정혁(Joung Hyouk),구정숙(Koo Jeong-Sook),전재흥(Jeon Jae-Heung) 한국원예학회 1991 한국원예학회 학술발표요지 Vol.9 No.1

위암의 AFP, TGF-β, EGF 및 AAT에 대한 면역조직화학적 연구

정숙금,최환준,구자영,허만하 대한병리학회 1994 Journal of Pathology and Translational Medicine Vol.28 No.5