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구본용,김찬영,양두현,황용,Koo Bon Yong,Kim Chan Young,Yang Doo Hyun,Hwang Yong 대한위암학회 2004 대한위암학회지 Vol.4 No.4
목적: 위암의 혈청 종양표지자인 CEA, CA 19.9, CA 72-4가 위암의 수술 전 평가 및 수술 후 재발 감시에 있어서 유용성이 있는지의 여부를 알아보기 위하여 본 연구를 시행하였다. 대상 및 방법: 1995년부터 2000년까지 위암으로 근치적 위절제술을 시행 받은 환자 중 수술 전, 수술 후 2주 그리고 6개월 간격의 추적 관찰 기간 동안 혈청 CEA, CA 19-9, CA 72-4 검사가 시행되었던 환자 255명을 대상으로 후향적 연구를 시행하였다. 종양표지자의 정상 참고치는 CEA의 경우 5 ng/ml, CA 19-9의 경우 36 U/ml, CA 72-4의 경우 4 U/ml로 하였다. 병기는 UICC TNM 병기분류법 제 5판에 준하여 분류하였다. 결과: 각 종양표지자의 수술 전 양성률은 CEA $10.5\%$, CA 19-9 $9.7\%$, CA 72-4 $12.4\%$였고, 세 종양표지자 모두 근치수술 후 혈청치가 감소하였다. CEA가 종양크기와 통계적인 연관성이 없는 것을 제외하고, 세 종양표지자의 수술 전 혈청치는 종양침윤깊이, 종양크기, 림프절 전이, 병기 그리고 재발과 의의있는 연관성이 있었다. 재발 환자에 있어서 종양표지자의 민감도는 CEA $43.3\%$, CA 19-9 $41.8\%$, CA 72-4 $50.0\%$였고, 특이도는 CEA $85.1\%$,CA 19-9 $96.8\%$, CA 72-4 $87.8\%$였다. 결론: CEA,CA19-9, CA 72-4의 수술 전 혈청치는 낮은 양성률 때문에 위암의 초기 진단에 유용성이 낮다. 그렇지만 수술 전 혈청치의 양성률이 종양침윤깊이, 림프절 전이, 종양크기, 병기, 재발과 연관성이 있고, 또한 수술 후 추적 관찰 중에 측정한 세 종양표지자의 혈청치도 비록 민감도는 낮지만 재발과 통계적으로 의의있는 연관성이 있다는 점을 고려해야한다. Purpose: This study was performed to evaluate the effectiveness of the serum tumor markers CEA, CA 19-9, and CA 72-4 in monitoring the recurrence of gastric cancer and in its preoperative assessment. Materials and Methods: Two hundred fifty-five patients who underwent potentially curative surgery during period from January 1995 to December 2000 at the Department of Surgery were assessed. Serum samples were obtained preoperatively, 2 weeks after the surgery, and at 6-month intervals. The cut-off levels were established as 5 ng/ml for CEA, 36 U/ml for CA 19-9, and 4 U/ml for CA 72-4. The tumor stage was described according to the 5th edition of the Union Internationale Contra la Cancer (UICC) TNM classification in 1997. Results: The preoperative positivities were $10.5\%$ for CEA, $9.7\%$ for CA 19-9, and $12.4\%$ for CA 72-4. The serum levels of the three tumor markers decreased after curative surgery. The preoperative serum levels of the three tumor markers were significantly related to the depth of invasion, the tumor size, lymph-node metastasis, the pathologic stage, and recurrence, except that CEA was not associated with tumor size. The marker sensitivities in recurrent cases were $43.3\%$ for CEA, $\%41.8$ for CA 19-9, and $50.0\%$ for CA 72-4, and the marker specificities were $85.1\%$ for CEA, $96.8\%$ for CA 19-9, and $87.8\%$ for CA 72-4. Conclusion: The preoperative serum levels of CEA, CA 19-9, and CA 72-4 are not useful for the initial diagnosis of gastric cancer because of their low positivity. However, we should consider their relationship with depth of invasion, lymph-node metastasis, tumor size, pathologic stage, and recurrence. Also, the follow-up levels of the three markers have a statistical relationship with recurrence of gastric cancer even though their sensitivities are low.
구본용(Bon Yong Koo),유희철(Hee Chul Yu),김광옥(Guang Yu Jin),황홍필(Hong Pil Hwang),김영곤(Young Kon Kim),곽효성(Hyo Sung Kwak),조백환(Baik Hwan Cho) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.74 No.4
As living-donor liver transplant techniques develop, variations in the portal vein are seen in approximately 20% of the population. However, congenital absence of the horizontal segment of the left portal vein is very rare and has not been reported in Korea. We present a case with a congenital absence of the horizontal segment of the left portal vein that was detected during an evaluation for a living donor liver transplantation, with a review of the relevant literature.
청소년의 유년기 무효화환경과 정서조절곤란의 관계에서 부정적 자동적사고와 경험회피의 영향
박영미(Young-mi Park),구본용(Bon-yong Koo) 영곡사회심리발달학회 2023 사회심리발달연구 Vol.4 No.1
목적 본 연구의 목적은 청소년의 유년기 무효화환경과 정서조절곤란의 관계에서 부정적 자동적 사고와 경험회피가 미치는 영향을 확인하는 것이다. 방법 이를 위해 전국 중·고등학교에 재학 중인 청소년 500명을 대상으로 온라인 방식으로 무효화환경, 부정적 자동적사고, 경험회피와 정서조절곤란에 관한 자료를 수집하여 분석하였다. 결과 연구결과를 요약하면 다음과 같다. 첫째, 청소년의 유년기 무효화환경과 정서조절곤란의 관계에서 부정적 자동적 사고의 매개효과가 나타났다. 둘째, 청소년의 유년기 무효화환경과 정서조절의 관계에서 경험회피의 매개효과가 나타났다. 셋째, 청소년의 유년기 무효화 환경과 정서조절 곤란의 관계에서 부정적 자동적 사고와 경험회피가 이중매개하는 것으로 나타났다. 결론 본 연구는 청소년의 무효화환경이 정서조절곤란을 야기하는 데 부정적 자동적 사고와 경험회피가 이중매개한다는 것을 경험적으로 확인하여, 이를 토대로 정서조절곤란의 어려움을 겪고 있는 청소년의 정서조절 능력을 향상시키기 위한 상담과 심리치료 프로그램 개발 필요성과 후속 연구를 제언하였다. Objectives The purpose of this study is to examine the impact of negative automatic thoughts and experiential avoidance on the relationship between invalidating environments and emotional dysregulation in adolescents. Methods To achieve this, data was collected and analyzed through an online survey from 500 adolescents enrolled in middle and high schools nationwide, focusing on invalidating environments, negative automatic thoughts, experiential avoidance, and emotion dysregulation. Results The summarized results of the study are as follows: Firstly, a mediating effect of negative automatic thoughts was found in the relationship between invalidating environments and emotional dysregulation in adolescents. Secondly, a mediating effect of experiential avoidance was observed in the relationship between invalidating environments and emotion dysregulation. Thirdly, it was found that negative automatic thoughts and experiential avoidance show a dual mediation effect in the relationship between invalidating environments and emotion dysregulation in adolescents. Conclusions This study empirically confirms that negative automatic thoughts and experiential avoidance are dual mediation factors in invalidating environments causing emotional dysregulation in adolescents. Based on these findings, it suggests the need for counseling and psychological treatment programs aimed at improving emotional regulation abilities for adolescents experiencing difficulties. Further research in this area is recommended.
유방암에 대한 술전항암화학요법(Neoadjuvant Chemotherapy)의 반응도에 따른 잔여종양조직의 병리학적 특성
김종완(Jong Wan Kim),정성구(Sung Ku Jung),엄태익(Taeik Eum),구본용(Bon Young Koo),강희준(Hee Joon Kang),김이수(Lee Su Kim) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.75 No.1
Purpose: There are questions about selecting the best postoperative chemotherapeutic regimen for breast cancer patients who have different response rates after neoadjuvant chemotherapy. The aim of this study was to examine the pathologic findings of residual tumors according to the response rate after neoadjuvant chemotherapy for breast cancer. Methods: We obtained specimens of residual tumors from 43 breast cancer patients who received neoadjuvant chemotherapy followed by curative operation at the Department of Breast and Endocrine Surgery, Sacred Heart Hospital, between Oct. 2002 and Oct. 2006. Four patients received 3 cycles of FAC (5-FU, Adriamycin, Cyclophosphamide) and 39 patients received 3 cycles of AT (Adriamycin, Docetaxel). We analyzed the pathologic characteristics according to the response rate. Results: The clinical response rate for neoadjuvant chemotherapy was 69.8%. There was no significant difference in the response rate for neoadjuvant chemotherapy between the AT and the FAC regimen groups. The tumors of the complete response group showed to be more ER-negative, PR-positive, p53-negative and c-erb-B2-positive and they had a lower Ki-67 staining index than the tumors of the partial response group. Moreover, the tumors of the clinical complete response group showed more triple (ER/PR/c-erb-B2) negative tumor than did the tumors of the partial response group. Conclusion: Although the tumor responded to neoadjuvant chemotherapy, the pathologic findings of the residual tumors in the clinical complete response group differed from that of the partial response group. So, this should be considered for the selection of postoperative chemotherapeutic agents.