비알코올성지방간의 유관 인자 임상 연구: 종양표지자, 심박변이도, 사상체질

곽시라,신뢰,박수정,권영미,주종천 사상체질의학회 2019 사상체질의학회지 Vol.31 No.2

Objectives The aim of this study is to investigate the related factors of nonalcoholic fatty liver disease (NAFLD). Methods The subjects were 187 persons diagnosed as fatty liver by abdominal ultrasonography. They were divided into three groups according to the severity of fatty liver: control, mild, moderate or severe. The three groups' general characteristics, laboratory results, liver function indexes, metabolic syndrome indexes, tumor markers, heart rate variability values and Sasang constitution distribution were compared and analyzed. Results Male ratio, height, weight, body mass index, red blood cell count, hemoglobin level and creatinine level were higher in NAFLD groups than in control group. The levels of sodium and amylase were higher in control than in NAFLD. In liver function, the levels of aspartate transaminase, alanine transaminase and gamma-glutamyl transpepsidase of NAFLD were higher. In metabolic syndrome index, systolic blood pressure, diastolic blood pressure, waist circumference, total cholesterol, triglyceride and low density lipoprotein cholesterol levels were higher in NAFLD, while high density lipoprotein cholesterol level was higher in control. The alpha-feto protein level was higher in NAFLD, and the heart rate variability was not different between NAFLD and control groups. In Sasang constitution, Taeeumin ratio of NAFLD was higher than of control. Conclusions The results suggest that nonalcoholic fatty liver is clinically related to liver dysfunction, metabolic syndrome, tumor markers, and Sasang constitution. Further studies are needed to control nonalcoholic fatty liver disease and prevent severe disease such as cirrhosis and cancer caused by fatty liver.

식도암 한의 임상진료지침 개발 예비 연구

곽시라,최진양,주종천,유화승,박수정,Gwak, Si-Ra,Cui, Zhenyang,Joo, Jong-Cheon,Yoo, Hwa-Seung,Park, Soo-Jung 대한암한의학회 2017 大韓癌韓醫學會誌 Vol.22 No.1

Objectives: The purpose of this study was to suggest the direction for the development of a clinical practice guideline (CPG) for esophageal cancer (EC). Methods: We collected and analyzed CPGs and related data about esophageal cancer by searching the database of domestic and foreign articles. Results: There were little contents or proposals related to Korean Medicine (KM) or Traditional Chinese Medicine (TCM), those related to KM or TCM can be found only in "Guidelines of Diagnosis and Therapy in Oncology with Traditional Chinese Medicine (惡性腫瘤中醫診療指南)". They were symptom factors, syndrome differentiation (SD) and 'treatment process of esophageal cancer by combination of western medicine and Korean medicine'. Conclusions: The topics of the development Korean medicine CPG for EC are (1) the method and procedure about combination of western medicine and Korean medicine (2) the process of SD and diagnosis (3) safety and efficacy of the herbal medicine and preparation (4) availability and timing of the tools related to KM or TCM like acupuncture, moxibustion, massage, etc.

중국 공조직에서 동료의 인상관리전략이 조직구성원의 인상관리동기에 미치는 영향

곽시도,최경주,김민정 부산대학교 중국연구소 2022 Journal of China Studies Vol.25 No.1

Effectiveness and Safety of Hwangchil–Unripe Bokbunja Extract Mixture on Blood Pressure: A Randomized Double-Blind Placebo-Controlled Clinical Trial

신뢰,곽시라,주종천,하기찬,박유경,김선오,박수정 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.3

From 25% to 50% of adults are affected by prehypertension. Prehypertension increases the risk of hypertension and affects the heart and systemic vascular system. Food mixed tree essence of Dendropanax morbifera called Hwangchil in Korean and immature fruit of Rubus coreanus, called Bokbunja (HDR-2), have been studied for safety and effectiveness against prehypertension studies. This study was a randomized double-blind placebo-controlled multicenter clinical trial lasting 19 months from October 2017 to May 2019. The 88 subjects who enrolled in the study were divided into two groups. The treatment group was provided HDR-2 and the other group took a placebo. Both HDR-2 and placebo were in the form of capsules, and the dose was 900 mg per day. Subjects took HDR-2 or placebo capsules once a day for 8 weeks before dinner. The primary observational indicators were systolic blood pressure (SBP) and diastolic blood pressure (DBP), and the secondary observational indicators were mean arterial pressure (MAP), mean pulse pressure, pulse rate, angiotensin-converting enzyme activity, renin activity, aldosterone, and highly sensitive-C reactive protein. The number of measurements was three times: the first visit in the screening week, the second visit in 4 weeks, and the third visit was after 8 weeks. Significant study results showed that the SBP and MAP of the HDR-2 group after 8 weeks were lower than those of the placebo group. Adverse events were not significantly different between the two groups. In conclusion, these results suggest that HDR-2 may be a useful intervention for the management of prehypertension. The protocol was registered in the Korean Clinical Trial Registration system (http://cris.nih.go.kr; registration number: KCT0004300).

두통으로 한방병원에 내원하여 컴퓨터단층촬영후 지주막하출혈로 진단된 증례 보고

박수정,곽시라,주종천,권영미,Park, Soo-jung,Gwak, Si-ra,Joo, Jong-cheon,Kwon, Young-mi 대한한방내과학회 2018 大韓韓方內科學會誌 Vol.39 No.4

The purpose of this study was to investigate the cases diagnosed as subarachnoid hemorrhage by noncontrast computed tomography (NCCT) after the appearance of symptoms related to headache and paralysis in patients who visited a Korean medicine hospital. A search of electronic medical records of patients diagnosed with subarachnoid hemorrhage on NCCT in W Korean medicine hospital from January 2010 to December 2017 identified five patients. The patients (four women and one man) ranged in age from 64 to 79 years old. Three were inpatients and two were outpatients. Two patients had hypertension, two patients had diabetes, two patients had heart disease, and two patients had a history of cerebral infarction. Development of a cooperative system is needed for accurate diagnosis and appropriate treatment of this disease in the Korean medicine clinic and for establishment of an NCCT scan application method.

흡입화상으로 유발된 만성 기관지염의 태음인 마황정천탕(麻黃定喘湯) 치험 1례

오승윤,곽시라,Oh, Seung-Yun,Gwak, Si-Ra 사상체질의학회 2020 사상체질의학회지 Vol.32 No.3

Objectives To report an improved case with Taeeumin Mahwangjeongcheon-tang on the patient with chronic bronchitis caused by an inhalation injury. Methods The patient had been suffered from cough, sputum, dyspnea, and chest discomfort for 15 years. He was diagnosed as Taeeumin Esophageal Cold Pattern and was given Mahwangjeongcheon-tang according to Sasang constitutional medical theory. The clinical asthma measurement scale in oriental medicine(CAMSOM-V), quality of life questionnaire for adult Korean asthmatics(QLQAKA), and Spirometry were performed to evaluate the improvement of his symptoms. Results The clinical asthma measurement scale in oriental medicine(CAMSOM-V) improved from 16 to 14 points and the quality of life questionnaire for adult Korean asthmatics(QLQAKA) improved from 55 to 67 points. In spirometry, forced vital capacity improved from 3.07 to 3.59, and forced expiratory volume in 1sec improved from 2.59 to 2.84 after 4 weeks. Conclusion This report suggests that Mahwangjeongcheon-tang is effective for chronic bronchitis.

중국 오태인 체질이론의 문헌연구: 체질 특성과 치료, 양생법

최진양,곽시라,주종천 사상체질의학회 2018 사상체질의학회지 Vol.30 No.1

Objectives Because of growing interest in personalized medicine, constitutional medicine also becomes more important. Constitutional medicine has already developed in many countries. In this study, we tried to investigate five type personality (Wutairen), a kind of Chinese constitutional medicine. Methods We did a research on five type personality using CNKI (http://www.cnki.net) up to Jan 15, 2018. Total 204 papers were searched with the keyword "Wutairen". We excluded 170 papers away from the subject or clinically studied. As a result, 34 papers were selected and analyzed. Results and Conclusions Five type personality (Wutairen) originated from Huangdi Neijing-Lingshu. There are 5 types: greater Yin person (Taiyin), lesser Yin person (Shaoyin), greater Yang person (Taiyang), lesser Yang person (Shaoyang) and Yin-yang balanced person. These are classified according to Yin-Yang content. Each type has different characteristic, treatment and prevention. Five type personality theory considers internal factors more important than external factors. Also, it considers the balance of Yin-Yang important.

형방지황탕가미로 치료한 만성 난치성 설사 치험 3례에 대한 임상적 고찰

이준영,채한나,문연주,이윤승,곽시라,문구,백동기 대한한방내과학회 2019 大韓韓方內科學會誌 Vol.40 No.5

Objective: This study reports the effect of Hyungbangjihwang-tang-gami as a treatment for Soyang-in patients with chronic diarrhea. Methods: We treated three male patients with chronic diarrhea who did not improve after taking herbal medicine, as determined by zang-fu (organ) pattern diagnosis. After changing our approach to a Sasang constitution, we prescribed Hyungbangjihwang-tang-gami and assessed the effect by the frequency or form of defecation. Results: The patients' complaints worsened when they were administered a herbal medicine unsuited to their Soyang constitutions, which caused an exuberance of Yang. Changing the herbal medicine to Hyungbangjihwang-tang-gami improved their symptoms. Conclusions: This study suggested that Soyang-in patients may have side effects when administered unsuitable herbs, even if they were diagnosed using zang-fu (organ) pattern diagnosis. When we treat patients, we have to consider their Sasang constitution, as well as the zang-fu (organ) pattern diagnosis.

태음인 약재의 사상의학적 병리 연구

유승엽,최나래,오승윤,곽시라,최진양,주종천,박수정,Ryu, Seung-Yeob,Choi, Na-Rae,Oh, Seung-Yun,Gwak, Si-Ra,Cui, Zhenyang,Joo, Jong-Cheon,Park, Soo-Jung 사상체질의학회 2018 사상체질의학회지 Vol.30 No.2

Objective This study was designed to define the efficacy of medicinal herbs of Taeeumin in Sasang constitutional medicine. Method We searched and analyzed original text such as Donguisusebowon Sinchuk edition written in 1901, Donguisusebowon Gabo edition written in 1894, Donguisusebowon Sansang Chobongwon, and posthumous manuscripts left by Je-ma Lee published by the Ministry of Health of North Korea. Results Seven herbs such as Ephedrae Herba, Coicis Semen, Castaneae Semen, Fel Ursi, Mori Cortex Radicis, Ginkgonis Semen, and Farfarae Flos regulate the mechanism of Esophagus-Cold (Wiwanhan). Three herbs such as Melonis Pedicellus, Ailanthi Radicis Cortex, and Quisqualis Fructus regulate the mechanism of Cold Lung-Dry (HanpaeJo). Sixteen herbs such as Rhei Rhizoma, Angelicae Tenuissimae Radix, Puerariae Radix, Cimicifugae Rhizoma, Angelicae Dahuricae Radix, Moschus, Gleditsiae Spina, Mume Fructus, Aurum, Glycine Semen Germinatum, Ampelopsis Radix, Cornu rhinocerotis, Antelopis Cornu, Bomeolum, Bezoar Bovis, and Typhae Pollen regulate the mechanism of Liver-Heat (Ganyeol). Three herbs such as Chrysanthemi Indici Flos, Nelumbinis Semen, and Spirodelae Herba regulate the mechanism of Heat Lung-Dry (YeolpaeJo). Conclusion Forty four herbs of Taeeumin regulate the mechanisms of Esophagus-Cold (Wiwanhan), Cold Lung-Dry (HanpaeJo), Liver-Heat (Ganyeol), Heat Lung-Dry (YeolpaeJo) and correct the energy-fluid pathology of Taeeumin.