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RISS 인기검색어
- 검색키워드
- 저자 : 곽성욱 ( Sung Wook Kwak ) (검색결과 2 건)
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양규환,곽성욱,김선현,신영태,황희진,박노혁,염창환,Yang, Gu-Hwan,Kwak, Sung-Wook,Kim, Sun-Hyn,Shin, Young-Tae,Hwang, Hee-Jin,Park, No-Hyeok,Yeom, Chang-Hwan 한국호스피스완화의료학회 2009 한국호스피스.완화의료학회지 Vol.12 No.1
Purpose: Lymphedemas are tissue fluid swellings, usually on the arms or legs, and occur as a result of impaired lymphatic drainage. Presently, the most effective treatment available is complete decongestive physiotherapy (CDP). However, this therapy is ineffective in some patients and surgery may be indicated. Herein, we examined the efficacy of minimally invasive needle aspiration of the most enlarged areas in hypodermic adipose tissues, of patients who had failed CDP. Methods: We included 21 patients who were diagnosed with lymphedema stage II-III in the upper or lower extremities and visited the lymphedema clinic at a university hospital from September 1, 2003 to February 28, 2004. All patients had been treated with CDP at least once, but had failed to respond to the therapy for more than one year. Nine patients had breast cancer and 12 had cervical cancer. We identified the area with the most severe edema by using MRI and performed a 16-gauge angio-needle aspiration on the area. The patients were followed up for 3 months. Effectiveness of the treatment was evaluated by comparing the volume of edema before and after the treatment using Wilcoxon signed rank-test. Results: The mean reduction ratio of the volume of edema comparison normal volume was 41.1${\pm}$35.3% (P=0.001). There were no major or minor operative complications except localized hemorrhage. Conclusion: We conclude that a needle aspiration prior to other surgical treatments is relatively safe and effective for those patients who are unresponsive to CDP. 목적: 림프부종은 림프계 이상으로 림프액 이동이 원활하지 못하여 생기는 팔다리 조직의 팽창을 의미한다. 현재 가장 효과적인 치료법은 복합적인 림프부종 치료법이지만 이 치료는 수술적 치료가 요구되는 환자에게는 효과가 없다. 이번 연구에서는 물리 치료법에 실패한 환자의 피하 지방조직에 비침습적 바늘 흡인술을 실시하여 그 효과를 알아보고자 하였다. 방법: 2003년 8월 1일부터 2004년 2월 28일까지 일개대학 병원 림프부종 클리닉에 방문하여 상하지 림프부종 2${\sim}$3기를 진단받은 환자를 대상으로 실시하였다. 모든 환자는 1년 이상 복합적인 림프부종 치료법을 실시하였으나 치료에 반응이 없었으며 9명의 환자는 유방암, 12명의 환자는 자궁경부암 환자였다. 치료 전 자기공명영상(MRI)을 실시하여 부종이 가장 심한 부위를 찾아 바늘 흡인술을 실시한 후 3개월 동안 추적 관찰하였다. 치료의 효과는 치료 전과 치료 3개월 후 부종 부피를 계산하여 Wilcoxon signed rank-test를 통해 비교하였다. 결과: 치료 전과 치료 3개월 후의 평균 부종 감소율은 29.1%였다(P=0.001). 국소적 출혈 이외 다른 특별한 부작용은 없었다. 결론: 바늘 흡인술은 복합적인 림프부종 치료법에 반응이 없는 림프부종 2, 3기 환자에게 수술에 앞서 고려해볼 수 있는 안전하고 효과적인 방법이다.
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송제선 ( Je Seon Song ),김승혜 ( Seung Hye Kim ),김성오 ( Seong Oh Kim ),최병재 ( Byung Jai Choi ),김정희 ( Jeong Hee Kim ),곽성욱 ( Sung Wook Kwak ),정한성 ( Han Sung Jung ) 한국조직공학과 재생의학회 2010 조직공학과 재생의학 Vol.7 No.5
Many studies have found adult stem cells in human teeth or correlated tissues. However, most of these stem cells were found in the permanent teeth or pulp from exfoliated deciduous teeth. The aim of the present study was to characterize stem cells isolated from the functional dental pulp and periodontal ligament of deciduous teeth. Dental pulp tissue was obtained from deciduous teeth by extirpation during treatment for dental caries, and periodontal tissue was obtained from deciduous teeth that were extracted for orthodontic reasons or space management. We observed cell outgrowth from these tissues in ``explants culture``, and named these cells as deciduous dental pulp stem cells (DDPSCs) and deciduous periodontal ligament stem cells (DPDLSCs), respectively. These stem cells presented embryonic stem cell markers (Oct-4 and Nanog), an ectomesenchymal stem cell marker (Nestin), and mesenchymal stem cell markers (Stro-1 and CD146). In differentiation media, DDPSCs and DPDLSCs were able to change into cells that produce lipid vacuoles or cells that induce extracellular mineral aggregation, expressing genes correlated with adipogenesis (PPARγ2 and LPL) or osteogenesis (ALP and BSP), respectively. This is the first report of the presence of multipotent stem cells in the functional dental pulp and periodontal ligament tissue of deciduous teeth, which can be isolated using an explants culture method. These tissues can be obtained easily during routine dental procedures, and could therefore represent a good source of adult stem cells for use in regenerative medicine.
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