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RISS 인기검색어
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- 저자 : 고재경 ( J. K. Koh ) (검색결과 3 건)
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원발성 간암의 종양 표식자로서 DNase 와 Rnase 에 관한 연구
기춘석(Chun Suk Ki),신봉재(B J Shin),조성옥(S O Cho),한중수(J S Han),고재경(J K Koh) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.3
N/A Activities of acid deoxyribonuclease (DNase) and neutral ribonuclease (RNase) in liver tissue, serum and ascitic fluid and urinary excretion of the modified ribonucleosides were determined in patients with hepatocellular carcinoma (15 cases) and liver cirrhosis (18 cases) hospitalized in the department of internal medicine of Hanyang University Hospital. Comparing these results with those obtained from normal healthy persons (20 cases), the present study pursued whether these parameters could be used as diagnostic and biochemical markers for hepatocellular carcinoma. 1) Serum neutral RNase activity was unchanged in liver cirrhosis, but increased in hepatocellular carcinoma by 70% and the positive rate of the serum enzyme as a marker for hepatocellular carcinoma was 60%. 2) Ascitic fluid neutral RNase activity was increased in hepatocellular carcinoma by 54% as compared with that of liver cirrhosis, and the positive rate of the ascitic fluid enzyme as a marker for hepatocellular carcinoma was 67%. Rnases and proteins in ascitic fluid of hepatocellular carcinoma were isolated by a DEAE-cellulose column chromatography into 5 peaks each, of which two peak proteins and RNases appeared to be unique to the cancer. 3) Liver acid Dnase activity was unchanged in liver cirrhosis, but increased greatly in hepatocellular carcinoma (117% increase), and the positive rate of the liver enzyme as a marker for hepatocellular cancer was 80%. The present study indicate that serum and ascitic fluid RNase activity, liver acid Dnase activity and urinary excretion of modified ribonuclesides can be used for diagnostic and biochemical markers for hepatocellular carcinoma. The combined use of these parameters might be useful for making accurate diagnosis for hepatocellular carcinoma.
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CHEMICAL CHANGES DURING GERMINATION OF SOYBEAN(Ⅰ)
Lee, K. Y.,Lee, C. Y.,Kim, S. W.,Koh, J. H. 서울대학교 1958 서울대학교 論文集 Vol.7 No.-
A paper Chromatographic study on free amino acids and keto acids in the germinated soybean was performed. An unequal distribution of these compounds was noticed in a series of the plant sections. A possible mechanism involved in the seedling plant was discussed. Chemical changes in soybean that occur during its germination were investigated. The paper chromatogram amino acids revealed that the disintegration of cotyledon protein was homogeneous but the distribution of free amino acids is unequal between the sections of the root in a series. The profuse appearance of keto acids in the root demonstrated the active transamination proceeding in the young tissues. Possible relationship of those compounds have been reviewed.
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