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선천성 거대결장 및 특발성 거대결장에서 카할 세포의 역할
유수영,고용택,한애리,정순희,엄민섭,김일호,Yoo, Soo-Young,Koh, Yong-Taek,Han, Ai-Ri,Jung, Soon-Hee,Eom, Min-Seob,Kim, Il-Ho 대한소아외과학회 2002 소아외과 Vol.8 No.2
The etiology of several motility disorders, including persistent megacolon after definitive surgery for Hirschsprung's disease, meconium ileus which is not associated with cystic fibrosis and idiopathic megacolon, is still unclear. Interstitial cells of Cajal (ICC) are thought to modulate gut motility as gastrointestinal pace maker cells. The aim of this study was to evaluate the role of ICC in the bowel walls of the patients (n=15) who had variable motility disorders. The ICC were identified by immunohistochemical staining using an anti-C-Kit antibody and the results were compared with control specimens (n=2). The control group (G1) showed evenly distributed ICC in their bowel walls. The second group (G2, n=5) who had normal bowel movements after Duhamel procedures and the third group (G3, n=4) who had persistent megacolon after Duhamel procedures showed absent or scarcely distributed ICC in their aganglionic bowels. The ICC were immunohistochemical staining using an anti-C-Kit antibody and the results were compared with control specimens (n=2). The control group (G1) showed evenly distributed ICC in their bowel walls. The second group (G2, n=5) who had normal bowel movements after Duhamel procedures and the third group (G3, n=4) who had persistent megacolon after Duhamel procedures showed absent or scarcely distributed ICC in their aganglionic bowels. Whereas ICC were evenly distributed in the ganglionic bowels of G2, they were not seen or scarecely distributed in the ganglionic bowels of G3. Two patients (G4) who suffered from idiopathic megacolon showed absence or decrease of ICC in spite of presence of ganglion cells in their colons. Four neonates (G5) who underwent ileostomy because of meconium obstruction showed absent or markedly decreased ICC in the the colon at the time of ileostomy and the distribution of ICC was changed to a normal pattern at the time of ileostomy closure between 39-104 days of age and their bowel motility were restored after that. The results suggest that lack of ICC caused reduce motility in the ganglionic colons and it may be responsible for the development of various motility disorders. Delayed maturity of ICC may also playa role in the meconium obstruction of neinates.
대형 평판재하시험을 통한 PF 공법의 하중전이 특성 분석
강민수 ( Kang¸ Min-su ),조명수 ( Jo¸ Myung-su ),고용택 ( Koh¸ Yong-taek ) 한국건축시공학회 2021 한국건축시공학회 학술발표대회 논문집 Vol.21 No.2
The general ground conditions in Korea are distributed in order of fill, deposit soil, weathered soil, weathered rock, soft rock. The fill soil and deposit soil located at the top have relatively low strength compared to the lower layer, and they are sometimes classified as soft ground according to the standard penetration test results. In this study, the PF method, a ground improvement method, was applied to the soft layer, a large plate load test was conducted on the improved ground, and the results were reviewed.