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백서 기도 평활근의 장력에 미치는 Mivacurium의 효과
신용섭,이원형,최세진,이정은,손수창,고영권 대한마취과학회 2000 Korean Journal of Anesthesiology Vol.39 No.4
Background: Neuromuscular blocking drugs are designed to specifically block nicotinic cholinergic receptors at the neuromuscular junction, but many bind to muscarinic cholinergic receptors on ganglia, nerve endings, and smooth muscles, thereby altering parasymphathetically mediated airway caliber and heart rate. Methods: We studied the effects of mivacurium on the tension of tracheal smooth muscle by using an isolated rat tracheal preparation. We studied the cumulative effect of acetylcholine after pretreating the tracheal smooth muscle with mivacurium at different concentrations, as well as the effect of L-NAME and propranolol on the tension of tracheal smooth muscle after pretreating with mivacurium. Results: Mivacurium shifted the acetylcholine dose-response curve to the right. L-NAME and pro- pranolol had no effect on the tension of tracheal smooth muscle after pretreating with mivacurium. Conclusions: We have found that mivacurium relaxes isolated rat tracheal smooth muscle and this effect has no relationship to beta-receptors or nitric oxide.