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강하은(Ha-Eun Kang),조영아(Young-A Cho) 한국산학기술학회 2017 한국산학기술학회논문지 Vol.18 No.11
최근 아동학대 사건이 증가하고 있으며, 이에 대한 사회적 관심이 높아지고 있다. 본 연구의 목적은 아동의 학대경험과 거부민감성 및 정서조절의 관계를 살펴보고, 아동의 학대 경험과 정서조절의 관계를 거부민감성이 매개하는지 알아보는데 있다. 이를 위하여 서울·경기, 강원, 충청, 경상지역 지역아동 보호기관에 아동학대로 신고 접수 되었거나 학대의심사례로 관리되고 있는 초등학교 4, 5, 6학년 아동 217명을 대상으로 아동학대, 거부민감성, 정서조절에 대한 설문을 실시한 후 구조모형 검증과 부트스트랩을 통해 매개효과를 살펴보았다. 연구결과 첫째, 아동의 학대 경험은 정서조절과 유의미한 부적상관이, 거부민감성과는 유의미한 정적상관이 있었다. 정서조절은 거부민감성과 유의미한 부적상관이 있었다. 둘째, 거부민감성은 아동의 학대 경험과 정서조절을 완전 매개하는 것으로 나타났다. 이러한 결과는 아동의 학대 경험이 거부민감성을 매개로 정서조절에 간접적으로 영향을 미친다는 것을 의미한다. 따라서 학대경험으로 인해 정서조절의 어려움을 겪는 아동을 상담할 때, 상담자는 이들의 거부민감성을 낮추는 상담개입전략을 구사할 필요가 있다. Recently, the number of cases of child abuse has been increasing and, consequently, the social interest in this issue is increasing. The purpose of this study is to examine the relationship between child abuse, rejection sensitivity and emotional regulation and to identify the mediating effects of rejection sensitivity in the relationship between child abuse and emotional regulation. For this purpose, a survey on child abuse, rejection sensitivity and emotional regulation was administered to 217 elementary school students in the fourth, fifth and sixth grades, who had been reported as victims of child abuse or managed as suspected child abuse victims in the Seoul, Gyeonggi, Gangwon, Chungcheong, and Gyeongsang regions. The data was analyzed using structural equation modelling and bootstrapping. The findings showed that child abuse was significantly negatively correlated with emotional regulation, but positively correlated with rejection sensitivity. Emotional regulation was significantly negatively correlated with rejection sensitivity. Second, the structural equation analysis also revealed that rejection sensitivity fully mediated the relationship between child abuse and emotional regulation. This means that child abuse has an indirect effect on emotional regulation through rejection sensitivity. Therefore, when counseling abused children with emotional regulation problems, it is important for the counselors to include interventions designed to lower their rejection sensitivity.
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큰종기와 유사한 임상 소견을 보인 피부에 국한된 다발성 Rosai-Dorfman Disease 1예
강하은 ( Ha Eun Kang ),김지연 ( Chi Yeon Kim ) 대한피부과학회 2023 대한피부과학회지 Vol.61 No.10
Rosai-Dorfman disease (RDD) is a rare and non-neoplastic histiocytic proliferative disorder, whose most common clinical presentation is massive but painless cervical lymphadenopathy. The cutaneous form of RDD is rare, and usually presents as erythematous to brown papules, plaques, or nodules. Most lesions are located on the face and trunk. We herein describe the case of a 52-year-old female patient with RDD clinically limited to the skin. The patient presented with asymptomatic multiple erythematous inflammatory nodules on the right flank and nasal area. Histopathologic findings showed multiple foamy histiocytic infiltrations in the dermis. On immunohistochemistry, the lesions were positive for CD68 and S-100, and negative for CD1a. The patient was treated with oral methylprednisolone, prednicarbate ointment and intralesional injection of triamcinolone acetonide. After 3 months, the lesions achieved almost complete remission, and the patient has been under observation without recurrence for the past 1 year. (Korean J Dermatol 2023;61(10):626∼629)
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하영술(Young-Sool Hah),김은지(Eun-Ji Kim),구영민(Young Min Goo),길영숙(Young Sook Kil),신승미(Seung Mi Sin),김상곤(Sang Gon Kim),강하은(Ha Eun Kang),윤태진(Tae-Jin Yoon) 한국생명과학회 2022 생명과학회지 Vol.32 No.5
멜라닌 색소는 피부색의 주요 원인이다. 멜라닌 색소는 멜라닌 세포에서 생성된 다음 각질 세포로 전달되어 결국 피부 표면에 다양한 색상을 부여한다. 많은 탈색제 및 피부 미백제가 개발되었지만, 색소 침착을 감소시키기 위한 재료에 대한 수요는 여전히 증가하고 있다. 본 연구에서 천연 화합물을 사용하여 탈색 및 피부 미백에 대한 재료를 찾으려고 시도한 결과 겨우살이(Viscum album var. coloratum) 추출물이 색소침착을 억제할 수 있음을 발견하였다. 인간 멜라닌 세포에 겨우살이 추출물(mistletoe extracts, ME)을 처리했을 때 색소 침착이 극적으로 감소하였다. 프로모터 리포터 분석은 ME 처리가 HM3KO 흑색종 세포에서 microphthalmia-associated transcription factor (MITF), melanophilin (MLPH), tyrosinase related protein 2 (TRP-2), and tyrosinase (TYR) 유전자의 전사를 억제한다는 것을 보여주었다. 일관되게 ME는 MITF, TRP-1 및 TYR과 같은 색소 침착 관련 분자의 단백질 수준을 감소시켰다. 또한 ME는 cAMP Responsive Element Binding Protein (CREB), AKT 및 ERK의 인산화를 감소시켰다. 이러한 결과는 ME가 색소 침착과 관련된 세포 내 신호 전달의 조절을 통해 멜라닌 생성을 억제한다는 것을 시사한다. 끝으로 ME는 색소 침착에 대한 생체 내 평가 모델인 제브라피쉬 배아의 멜라닌 생성을 현저하게 억제하였다. Melanin pigments are the main cause of skin color. They are produced in melanocytes and then transferred to keratinocytes, which eventually gives the skin surface a variety of colors. Although many skin-lightening or depigmenting agents have been developed, the demand for materials to reduce pigmentation is still increasing. Here, we tried to find materials for skin-lightening or depigmentation using natural compounds and found that mistletoe (Viscum album var. coloratum) extracts (ME) had an inhibitory effect on tyrosinase activity. As a result, ME significantly reduced pigmentation in human primary melanocytes. In addition, a promoter reporter assay revealed that ME inhibited the transcription of microphthalmia-associated transcription factor (MITF), melanophilin (MLPH), tyrosinase-related protein-2 (TRP-2), and tyrosinase (TYR) genes in HM3KO melanoma cells. In addition, ME decreased the protein level for pigmentation-related molecules, such as TYR and TRP-1. Furthermore, it markedly inhibited the melanogenesis of zebrafish embryos, an in vivo evaluation model for pigmentation. To elucidate the action mechanism of ME, we investigated its effects on intracellular signaling. Eventually, the ME dramatically decreased the phosphorylation of the cAMP responsive element binding protein (CREB), AKT, and ERK. The data suggest that ME may inhibit the melanogenesis pathway by regulating the signaling pathway related to pigmentation. Taken together, these data propose that ME can be developed as a depigmenting or skin-lightening agent.
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정서미곤 ( Seo Mi Gon Jeong ),진유경 ( Yu Kyung Jin ),강하은 ( Ha Eun Kang ),김지연 ( Chi Yeon Kim ) 대한피부과학회 2023 대한피부과학회지 Vol.61 No.10
Acroangiodermatitis (AAD) is a rare reactive vasculo-proliferative disorder associated with chronic venous hypertension. Owing to its clinical and histological similarities to Kaposi sarcoma, AAD is also known as pseudo-Kaposi sarcoma. AAD is characterized by several clearly defined red-purple papules, plaques or ulcerations located on the dorsum of the foot and medial lower limbs. We describe the case of a 36-year-old woman who had multiple red-purple papules and plaques on the dorsum of the right foot area. A skin biopsy was performed, and histopathological examination revealed the presence of multiple capillaries lined by a single layer of endothelial cells surrounded by hemosiderin deposits. No specific histological features of Kaposi sarcoma were observed. Immunohistochemical analysis showed CD31+ positivity in endothelial cells. The patient was diagnosed with AAD and the lesions have shown no remission for the past 7 years. Therefore, follow-up biopsies are performed every 2 or 3 years to monitor for any potential malignant changes. (Korean J Dermatol 2023;61(10):634∼638)
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