보르테조밉 재투여에 의해 발생한 스위트 증후군 1예

정서미곤 ( Seo Mi Gon Jeong ),권창일 ( Chang Il Kwon ),김지연 ( Chi Yeon Kim ) 대한피부과학회 2021 大韓皮膚科學會誌 Vol.59 No.4

Sweet syndrome is characterized by fever, tender, erythematous skin lesions, neutrophilia, high levels of serum inflammatory markers, and diffuse mature neutrophil infiltration typically localized to the upper dermis. Various drugs have been shown to be associated with Sweet syndrome. Bortezomib, a proteasome inhibitor approved for the treatment of multiple myeloma, has been reported to be associated with erythema, pruritus, eczemas, and, rarely, erythema multiforme-like skin changes or vasculitis. We describe a case involving a 65-year-old male who received bortezomib for the treatment of multiple myeloma. Over three cycles, multiple nodular lesions recurred through periods of aggravation and relief from symptoms. On the basis of the signs, symptoms, and biopsy results, the patient was diagnosed as showing Sweet syndrome. Skin lesions that occur during treatment of underlying disease can affect the patients’ treatment compliance. This case report indicates that a bortezomib rechallenge is an option for patients who develop sweet syndrome. (Korean J Dermatol 2021;59(4):299∼302)

Human Immunodeficiency Virus 치료와 단파장 자외선B 요법으로 호전을 보인 결절성 양진 1예

정서미곤 ( Seo Mi Gon Jeong ),권창일 ( Chang Il Kwon ),김지연 ( Chi Yeon Kim ) 대한피부과학회 2021 대한피부과학회지 Vol.59 No.6

Prurigo nodularis (PN) is a chronic cutaneous condition characterized by a papulonodular pruriginous eruption accompanied by pruritus. PN lesions are typically firm and itchy hyperkeratotic nodules and papules, which provoke a scratch response. PN may often represent an initial cutaneous manifestation of human immunodeficiency virus (HIV) infection. The association between PN and HIV is attributable to various etiopathogenetic mechanisms including cutaneous immunological abnormalities. Diagnosis of HIV infection in a patient with PN is challenging. We report a case of confirmed HIV infection in a patient with treatment-resistant PN, who was successfully treated using combination treatment that included HIV antiretroviral therapy and narrow-band ultraviolet-B radiation. (Korean J Dermatol 2021;59(6):487∼490)

다발성 구진성 병변으로 나타난 무백혈성 피부 백혈병 1예

정서미곤 ( Seo Mi Gon Jeong ),이경원 ( Gyeong-won Lee ),김지연 ( Chi Yeon Kim ) 대한피부과학회 2022 대한피부과학회지 Vol.60 No.1

Leukemia cutis (LC) is a cutaneous condition caused by leukemia cells leaching into the skin, with various clinical manifestations. At times, skin lesions called aleukemic LC occur before leukemia cells appear in the bone marrow or peripheral blood. Proper diagnosis of such a condition is important for early detection, treatment, and prognosis of leukemia. In general, LC is usually associated with an unfavorable prognosis. Herein, we report a case of a 65-year-old male with LC who presented with multiple papular lesions on the trunk and extremities. Histopathological examination of the lesions revealed LC of the monocytic type. Additional laboratory tests of the peripheral blood were normal, but a bone marrow biopsy demonstrated a high proportion of leukemic cells. In conclusion, we present this case to highlight that early diagnosis and accurate management are crucial for the prognosis of patients affected with leukemia, especially when skin lesions are the first clinical symptom. (Korean J Dermatol 2022;60(1):57∼60)

Trichophyton tonsurans에 의한 두부독창 1예

정서미곤 ( Seo Mi Gon Jeong ),권창일 ( Chang Il Kwon ),김지연 ( Chi Yeon Kim ) 대한피부과학회 2021 大韓皮膚科學會誌 Vol.59 No.9

Trichophyton tonsurans is an anthropophilic endothrix dermatophyte that has been the main causative organism of tinea capitis in the United States, Canada, Mexico, and other Latin American countries. In Korea, tinea capitis caused by T. tonsurans has been reported since 1995, but kerion celsi caused by T. tonsurans is rare. Kerion celsi is an inflammatory suppurative dermatophytosis of the scalp associated with hair loss. In this study, we report a case of kerion celsi occurring on the parietal scalp of a 6-year-old child diagnosed in a mycological study. T. tonsurans was identified and treated with oral itraconazole and topical epiconazole. (Korean J Dermatol 2021;59(9):720∼723)

임신 중에 발생한 전격성 주사 2예

정서미곤 ( Seo Mi Gon Jeong ),신영빈 ( Young Bin Shin ),권창일 ( Chang Il Kwon ),김지연 ( Chi Yeon Kim ) 대한피부과학회 2021 大韓皮膚科學會誌 Vol.59 No.2

Rosacea fulminans is an extreme form of rosacea characterized by a rapid onset and fulminating course with prominent erythema, pustules,and cysts on the face. It can have an impact on obstetrical outcomes, and its treatments may have limitations during pregnancy. A 33-year-old woman and a 22-year-old woman presented with rosacea fulminans during the first pregnancy andwere treated with erythromycin and prednisone, respectively. After delivery, there was a significant improvement in the lesion. Rosacea fulminans recurred during the second pregnancy, but the skin lesions showed better progression. Rosacea fulminans can causesevere distress and different outcomes of pregnancy. It is recommended to consult about the risk of recurrence in future pregnancies. (Korean J Dermatol 2021;59(2):148∼152)

울체피부염의 임상적 특징과 동반된 혈관 질환을 평가하기 위한 영상의학적 검사에 관한 연구

정서미곤 ( Seo Mi Gon Jeong ),김지연 ( Chi Yeon Kim ) 대한피부과학회 2021 大韓皮膚科學會誌 Vol.59 No.9

Background: Stasis dermatitis is an inflammatory skin disease that occurs in the lower legs of patients with chronic venous insufficiency; however, data on combined vascular disease and stasis dermatitis are limited. Objective: This study aimed to evaluate the clinical features of patients with stasis dermatitis and combined vascular diseases. Methods: We retrospectively reviewed the clinical features and combined vascular diseases of 37 patients clinically diagnosed with stasis dermatitis who visited the dermatology department from January 2017 to December 2020. Results: The average age of occurrence was 59.5 years, and the average duration of the disease was 3.2 years. Stasis dermatitis was more likely to occur in women than in men and more often in both lower legs. The major clinical features were erythematous patches. Asymptomatic symptoms were most common, followed by itching and tenderness. To evaluate vascular diseases, ultrasonography, venography computed tomography (CT), and angiography CT were performed. The most common combined vascular diseases were deep vein thrombosis, followed by varicose vein and thrombophlebitis. Most cases were treated with topical steroids and antihistamines, and anticoagulants/antiplatelet agents were used to treat vascular diseases. Conclusion: Stasis dermatitis is mainly associated with venous dysfunction in the lower legs. Early diagnosis and fundamental treatment of combined vascular diseases by evaluating vascular function in patients suspected of stasis dermatitis are important. This study will provide dermatologists with significant data on the clinical features of stasis dermatitis and combined vascular diseases. (Korean J Dermatol 2021;59(9):669∼675)

오른쪽 발등에 발생한 선단혈관피부염 1예

정서미곤 ( Seo Mi Gon Jeong ),진유경 ( Yu Kyung Jin ),강하은 ( Ha Eun Kang ),김지연 ( Chi Yeon Kim ) 대한피부과학회 2023 대한피부과학회지 Vol.61 No.10

Acroangiodermatitis (AAD) is a rare reactive vasculo-proliferative disorder associated with chronic venous hypertension. Owing to its clinical and histological similarities to Kaposi sarcoma, AAD is also known as pseudo-Kaposi sarcoma. AAD is characterized by several clearly defined red-purple papules, plaques or ulcerations located on the dorsum of the foot and medial lower limbs. We describe the case of a 36-year-old woman who had multiple red-purple papules and plaques on the dorsum of the right foot area. A skin biopsy was performed, and histopathological examination revealed the presence of multiple capillaries lined by a single layer of endothelial cells surrounded by hemosiderin deposits. No specific histological features of Kaposi sarcoma were observed. Immunohistochemical analysis showed CD31+ positivity in endothelial cells. The patient was diagnosed with AAD and the lesions have shown no remission for the past 7 years. Therefore, follow-up biopsies are performed every 2 or 3 years to monitor for any potential malignant changes. (Korean J Dermatol 2023;61(10):634∼638)

40세 여성에서 발생한 극세포해리 극세포종 1예

권창일 ( Chang Il Kwon ),정서미곤 ( Seo Mi Gon Jeong ),김지연 ( Chi Yeon Kim ) 대한피부과학회 2021 大韓皮膚科學會誌 Vol.59 No.7

Acantholytic acanthoma is a rare benign neoplasm of epidermal keratinocytes that clinically presents as a solitary, asymptomatic keratotic papule or nodule on the trunk. A 40-year-old female visited our hospital with a 20-year history of a single papule on her right thigh. On physical examination, the lesion measured 0.5×0.4 cm in size and appeared brown in color with central hyperkeratosis. Histopathological evaluation showed hyperkeratosis, acanthosis, papillomatosis, dyskeratosis, and acantholysis. Only six cases of acantholytic acanthoma have been reported in Korea. We report a rare case of acantholytic acanthoma that occurred in a 40-year-old female who presented with a keratotic papule on her right thigh. (Korean J Dermatol 2021;59(7):564∼567)

손등에 발생한 원발 피부 역형성 대세포 림프종 1예

권창일 ( Chang Il Kwon ),정서미곤 ( Seo Mi Gon Jeong ),김지연 ( Chi Yeon Kim ) 대한피부과학회 2021 대한피부과학회지 Vol.59 No.4

Primary cutaneous anaplastic large cell lymphoma is primary cutaneous lymphoma that is composed of large lymphoid cells with anaplastic and pleomorphic morphology and expresses the CD30 antigen. Generally, primary cutaneous anaplastic large cell lymphoma is represented by a single, erosive plaque located on the trunk or extremities, but rarely on the dorsum of the hand. A 36-year-old man visited our hospital with a plaque on the dorsum of his left hand for 2 months. The plaque was 6×5 cm in size and violet-colored, with erosion. Histopathological findings showed infiltration of large anaplastic cells in the dermis and subcutaneous fat tissue. Immunohistochemically, it showed positive results for CD3, CD4, and CD30 and negativity anaplastic lymphoma kinase. Imaging examination showed no additional lesions, and the diagnosis was confirmed as primary cutaneous anaplastic large cell lymphoma. The patient was treated with radiation therapy four times and the lesion completely disappeared. (Korean J Dermatol 2021;59(4):296∼298)