위암에서의 중합효소 연쇄반응에 의한 Epstein - Barr 바이러스의 검출과 LMP1 , p53 , CD44 의 발현

이명아(Myung Ah Lee),홍영선(Young Seon Hong),강진형(Jin Hyung Kang),이경식(Kyung Shik Lee),유진영(Jin Young Yoo),이교영(Kyo Young Lee) 대한내과학회 2002 대한내과학회지 Vol.63 No.3

N/A Background : Epstein-Barr virus (EBV) is associated with various lymphoproliferative disorders and nasopharyngeal carcinoma. Recently some of the tumor cells of gastric cancer were observed to contain EBV sequence. We detected EBV using PCR to determine the frequency of EBV associated gastric cancer, which is the most common cancer in Korea. We also performed immunohistochemical staining for the latent membrane protein (LMP1), p53 and CD44 to investigate the possible mechanism in EBV-associated gastric cancer. Methods : Eighty-seven formalin-fixed and paraffin-embedded blocks (40 gastric adenocarcinomas, 34 adjacent normal tissues, 13 metastatic lymph nodes) from 40 surgically resected gastric specimens were studied. All patients were diagnosed as having gastric cancer at the Kang-Nam St. Mary's Hospital during the period of April 1995 to April 1997. DNA was extracted from each paraffin block and then we performed PCR and immunohistochemical staining for the LMP1, p53 and CD44. We reviewed the patients' charts for clinical information. Results : EBV was detected in 4 cases (10%) by EBV-PCR among the 40 patients. It was also detected in a metastatic lymph node in 1 patient. The immunohistochemical staining for the LMP1, p53 and CD44 was negative in all the EBV-positive cancer patients. Of the patients having these cancers, 2 had a poorly differentiated adenocarcinoma with a lymphoepithelioma-like morphology. Conclusion : The frequency of EBV-associated gastric cancer may be about 10% in Korea. Considering the negative result of the immunohistochemical staining for the LMP1, p53 and CD44, EBV-associated gastric cancer seems to have a different mechanism of tumorigenesis from ordinary gastric cancer or other EBV-associated cancers. This must be determined by further large scale studies. (Korean J Med 63:261-266, 2002)

Finger Gesture와 Voice Recognition을 활용한 IoT 통합 제어 웹 플랫폼

강진형(Jinhyeong Kang),김한주(Hanju Kim),김동호(Dong Ho Kim) 한국방송·미디어공학회 2022 한국방송공학회 학술발표대회 논문집 Vol.2022 No.11

증강현실로 날씨, 뉴스 요약 등이 제공되거나 AI 비서 기능을 제공하는 스마트 미러(smart mirror)가 개발되고 있다. 본 작품에서는 IoT 통합제어, 뉴스 요약 및 날씨 정보 제공 등의 서비스를 하나의 웹 플랫폼으로 구축하고 이를 손가락 제스쳐 및 음성 명령으로 제어하는 것을 제안하고 구현하였다. 본 작품에서는 음성 인식을 통해 IoT 서비스를 직관적으로 이용할 수 있게끔 설계하여 사용자의 편의성을 높였으며, 디바이스를 직접 터치하는 방식이 아닌 finger gesture로 제어하는 방식을 채택해, 디바이스 유지 보수 및 위생 문제를 해결하였다. 단순 IoT 통합 제어 기능뿐만 아니라 다양한 컨텐츠 및 기능을 제공함으로써 통합 플랫폼의 기능을 수행할 수 있도록 하였다. 뉴스 홈페이지에서 Crawling한 뉴스를 text rank 알고리즘을 이용. 자동으로 요약하는 기능과, 사용자의 IP를 기반으로 위도와 경도를 추론, 해당 지역의 일기 예보 정보를 표현해 주는 등 단순 IoT 제어 플랫폼이 아닌, 통합 플랫폼의 기능을 다하도록 설계하였다. 이처럼 다양한 정보를 압축해서 사용자가 편하게 볼 수 있도록 제공하며, 직관적인 two track 제어 방식을 채택. 사용 대상의 편의성을 증대시켜 본 프로젝트는 기존 프로젝트보다 사용자에게 더 나은 사용 경험을 제공할 것이다.

두경부암 환자에 병발된 위암 2예

강진형(Jin Hyoung Kang),문찬수(Chan Soo Moon),김훈교(Hoon Kyo Kim),이경식(Kyung Shik Lee),김동집(Dong Jip Kim),윤세철(Sei Chul Yoon),조승호(Seung Ho Cho),서병도(Byung Do Suh) 대한두경부종양학회 1992 대한두경부 종양학회지 Vol.8 No.1

The causes of treatment failure in head and neck cancer are locoregional recurrence, distant metastasis and second primary cancer. The favorite sites of second primary cancer are head and neck, lung and esophagus. But, the incidence of stomach cancer in Korea is the highest of all, high incidence of stomach cancer is expected in head and neck cancer patients. We experienced 2 cases of stomach cancer after successful treatment of primary head and neck cancer at Kang Nam St. Mary's hospital. The first case was a 60-year-old male with nasopharyngeal non-keratinizing carcinoma(stage III, T1N1M0). He received three cycles of induction chemotherapy including cisplatin and 5-fluorouracil followed by radiotherapy which resulted in complete response. Five months after completion of radiotherapy. stomach adenocarcinoma(stage IV, T4N2M1) was diagnosed. He received one cycle of FAM chemotherapy and died 4 months after diagnosis of stomach cancer. The second case was a 50-year-old male with pyriform sinus squamous cell carcinoma(stage II, T2N0M0). He received curative partial pharyngolaryngectomy followed by radiotherapy which result in free of disease. Four months after completion of radiotherapy. stomach adenocarcinoma(stage IV, T4N2M1) was diagnosed. Bypass gastrojejunostomy was performed. The screening test for stomach cancer including upper gastrointestinal X-xay series and/or endoscope of the stomach should be performed periodically for the patients with head and neck cancer in Korea.

검도 지도자의 신뢰와 수련만족이 재등록의도에 미치는 영향

강진형(Jin-Hyung Kang),김영주(Yeong-Ju Kim) 대한검도학회 2015 대한검도학회지 Vol.26 No.1

본 연구는 검도 수련 지도자 신뢰와 수련 만족이 재등록의도에 어떠한 영향을 미치는지를 분석하는데 목적이 있었다. 이를 위해 2015년 서울특별시와 경기도에 소재한 검도장에서 수련생을 모집단으로 본 연구의 목적에 부합된다고 판단한 남자 285명, 여자 75명, 총 426명을 편의표본추출(convenience sampling)방법으로 선정하였다. 수집된 자료는 SPSS ver 18.0 프로그램을 이용하여 탐색적 요인 분석과 신뢰도 분석, 독립 t-검증(independent samples t-test), 일원변량분산분석(One-way ANOVA)과 Duncan방법을 이용한 다중비교분석(multiple comparison analysis), 상관분석(correlation analysis), 다중회귀분석(multiple regression analysis)을 실시하였다. 그 결과 첫째, 성별에서는 지도자 능력, 교육프로그램, 재등록 의도에서 통계적으로 유의한 차이가 있었으며, 연령에서의 경우 지도자 성실성, 능력, 지도자 만족, 시설 만족에서 통계적으로 유의한 차이를 나타내었다. 수련기간에 있어서는 지도자 성설성, 능력, 시설만족, 재등록 의도에서 통계적으로 유의한 차이를 보였으며, 수련기간에 있어서는 모든 요인에서 통계적으로 유의한 차이를 보였다. 또한 수련 횟수에 있어서는 시설만족을 제외한 모든 요인에서 통계적으로 유의한 차이를 보였다. 둘째, 지도자 신뢰, 수련만족, 재등록의도 모든 요인에서 정적(+)상관이 있는 것으로 나타내었다. 마지막으로 지도자 신뢰의 성실성, 수련 만족의 지도자 만족, 교육프로그램만족은 재등록 의도에 영향을 미치는 것으로 분석 되었다. 이상의 결과를 종합해 볼 때, 검도 지도자의 신뢰와 수련만족은 재등록의도에 영향을 미친다는 것을 알 수 있다. The purpose of this study was to analyze how trust in kumdo instructors and satisfaction with training might affect intention for re-registration. For this, the study selected 426 persons in total (285 males, 75 females) using convenience sampling method from the trainees at kumdo training studios situated in Seoul and Gyeonggi-do in 2015, who were deemed to be appropriate for the purpose of this study. Using SPSS ver 18.0 program for the collected data, the study conducted exploratory factor analysis, reliability analysis, independent samples t-test, multiple comparison analysis via One-way ANOVA and Duncan method, correlation analysis as well as multiple regression analysis. The study had findings as below. First, by gender, there were statistically significant differences in terms of trust in instructors, education programs and intention for re-registration, and in the case of age, there were statistically significant differences in terms of instructor"s sincerity, their capability, satisfaction with facility, intention for re-registration, while in the area of training period, there were statistically significant differences in all factors. Also related with the number of training, there were statistically significant differences in all factors except satisfaction with facility. Second, all factors of trust in instructors, satisfaction with training and intention for re-registration had positive relationships. Lastly, trust in instructor"s sincerity relative to trust in instructors, satisfaction with instructors relative to satisfaction with training, satisfaction with education programs affected intention for re-registration. Considering all above results, the study could conclude that trust in kumdo instructors and satisfaction with training affect intention for re-registration.

몇가지 관해유도요법제에 의한 급성임파구성 백혈병의 관해율

강진형(Jin Hyoung Kang),진종률(Jong Youl Jin),홍영선(Young Seon Hong),한치화(Chi Wha Han),박종원(Jong Won Park),김춘추(Choon Choo Kim),김동집(Dong Jip Kim),김학기(Hack Ki Kim) 대한내과학회 1987 대한내과학회지 Vol.32 No.5

N/A The case analysis of 74 patients, who were admitted to St. Mary's hospital from Jan, 1982 to Dec. 1986, and had a diagnosis as acute lymphocytic leukemia by bone marrow aspiration and biopsy was conducted. Of all the patients, the number of patients who were treated with VP regimens were 7, VPM regimens 6, VP, L-asp. regimens 4, L2, regimens 28, Modified L, regimens 15, miscellaneous regimens 3 for induction of complete remission. All of them were 63. We could find several interesting informations about the CR rate, duration of CR, survival rate between several prognostic factors. The CR rate in VP regimens was 42.9%, VP. L-asp. regimens 60.7%, L, regimens 67.9%, Modified L, regimen 93.3% According to the FAB classification, there were no difference in CR rate. (L1 76.2%, L2 70.3%, L3 80%) In patients who had CHOP regimen as consolidation, median, duration of CR was longer (6.6 months) than that in patients without CHOP (3.8 months). In the comparison of duration of survival between the immunologic classification, median duration of survival in C-ALL was 12 months and T-ALL was 4.5 months. We might come to conclusion as follows; 1) Modified L2 regimen is superior to other regimens to bring CR. 2) Early consolidation therapy give us more longterm disease free survival. 3) The survival rate of C-ALL is better than that of T-ALL.

스키리조트 식음시설 서비스 품질에 대한 고객만족과 행동의도 관계

강진형(Kang Jin-Hyung),김학신(Kim Hak-Shin) 한국체육과학회 2003 한국체육과학회지 Vol.12 No.1

This study analysed structural relationship of ski-resort restaurant customers satisfaction and behavioral intentions for service quality. service quality factors was defined as tangibles, reliability, responsiveness, assurance, empathy. Behavioral intentions was defined as loyalty and brand switch. LISREL model' was used to develop dimensions of service quality of a ski-resort restaurant and to explore the relationship between overall service quality of a restaurant, customer satisfaction and behavioral intentions. The empirical results are as follows. First, It has a significant relationship between service quality and overall satisfaction. Second, It has a significant relationship between overall satisfaction and behavioral intentions. Author shows that overall service quality affects ski-resort customers satisfaction and behavioral intention.

지속적인 검도 훈련에 따른 비만 남학생의 혈중지질 변화

강진형(Jin-Hyung Kang),이춘형(Chun-Hyung Lee) 대한검도학회 2005 대한검도학회지 Vol.21 No.2

본 연구는 지속적인 검도활동을 하는 비만대상자에 의한 혈청지질(TC, TG, HDL-C, LDL-C)에 미치는 영향을 비교ㆍ분석하여 이를 통하여 비만 및 관상동맥질환의 발생 위험을 감소시키는 적절한 비만프로그램 마련을 위한 기초 자료를 제공하자 하며, 검도 운동을 하는 일반인들에게 활용될 수 있도록 하는데 목적이 있다. 본 연구의 결론은 다음과 같다. 첫째, 혈청 총 콜레스테롤(Total Cholesterol)에서는 비만 훈련집단이 비훈련집단 보다 감소를 보였으나 유의한 차이는 없었다. 둘째, 혈청 중성지방(Triglycerides)에서는 비만훈련집단이 비훈련집단 보다 감소를 보였으나 유의한 차이는 없었다. 셋째, 혈청 고밀도지단백 콜레스테롤(HDL-Cholesterol)에서는 비만훈련집단이 비훈련집단 보다 증가를 보이면서 유의한 차이가 있었다. 넷째, 혈청 저밀도지단백 콜레스테롤(LDL-Cholesterol)에서는 비만 훈련집단이 비훈련 집단 보다 감소를 보였으나 유의한 차이는 없었다. 이상의 결과를 종합하면 총콜레스테롤, 중성지방, 저밀도지단백질에서는 유의한 차이가 없었으나 심혈관계와 관련이 있는 고밀도지단백질 콜레스테롤에서는 유의한 차이가 있었다. The purpose of this study is to investigate the changes of serum lipoprotein by regular obese male student's Kumdo training. The subjects are divided into regular obese Kumdo training(n=10) and untrained groups(n=10) by men college student's. Also, these two groups were tested serum lipid lipoprotein(total cholesterol, HDL-cholesterol, triglyceride, LDL-cholesterol). The statistical analysis of the results is carried out t-test, The results were as follows : 1. The total cholesterol of the regular Kumdo training and untrained groups had no significant difference(P>0.05). 2. The triglycerides of the regular Kumdo training and untrained groups showed no significant difference(P>0.05). 3. The HDL-cholesterol of the regular Kumdo training increased significant difference (P<0.05). 4. The LDL-cholesterol of the regular Kumdo training had no significant difference(P>0.05). These results suggest that this kind of regular & continued Kumdo training can improve the changeability of serum high density lipid lipoprotein.

투수성 잔디블록 포장 하부 토양의 물리성

한승호,김원태,강진형,Han, Seung-Ho,Kim, Won-Tae,Kang, Jin-Hyoung 한국조경학회 2006 韓國造景學會誌 Vol.34 No.4

Impervious pavement is primary contributor to the malfunctioning of the urban water circulation system. The aim of this research is to provide basic information and data for new pavement materials and paving technology which could enhance the urban water circulation system. For the study purposes, physical properties of soils sampled from 16 stations were analyzed. The sampling spots were paved with grass block porous pavement material. The findings from the analysis are as follows. The hardness of soils under the pavement was $17{\sim}22mm$ for thoroughfare and $6{\sim}32mm$ for parking areas. The bulk density was $1.42{\sim}1.81g/cm^{3}$ for thoroughfare and $1.38{\sim}1.75g/cm^{3}$ for parking area. The solid phase ration was $46.9{\sim}62.5m^{3}/m^{3}$ for thoroughfare and $45.6{\sim}61.3m^{3}/m^{3}$ for parking area. The porosity was $37.5{\sim}53.1m^{3}/m^{3}$ for thoroughfare and $38.7{\sim}54.4m^{3}/m^{3}$ for parking area. The saturated hydraulic conductivity was $8{\sim}164mm/hr$ for thoroughfare and $14{\sim}201mm/hr$ for parking area. The saturated hydraulic conductivity of the H sample area (the area was completed three months ago) and that of the other area were compared. There was up to 80% decreases of the saturated hydraulic conductivity within one year after the completion of pavement. After the first year, decrease in the saturated hydraulic conductivity was modest. Also there are changes in both surface and under soil physical properties of the grass block porous pavement depending on compaction. The extent of change depends on the degree of compaction. All these factors are combined to influence the permeability of the soil under the pavements. The results of this suggest that it is required to develop a new pavement technology which ensures both the durability and porosity of the pavement to improve the water circulation system by applying Ecological Area Rate.

조경용 투수성 블록 포장의 열환경 특성

한승호,류남형,강진형,Han Seung-Ho,Ryu Nam-Hyong,Kang Jin-Hyoung 한국조경학회 2006 韓國造景學會誌 Vol.34 No.2

This study aims to measure and to analyze the thermal environment characteristics of the various permeable pavement materials such as grass pavement (GREEN BLOCK PARK), stone and grass pavement (GREEN BLOCK STEP), stone pavement (GREEN BLOCK MOSAIC) and wood pavement (WOOD BLOCK) under the summer outdoor environment. The thermal environment characteristics measured in the study includes the changes of surface temperature during the day, changes of the temperature on each pavement layer, and long and short wave radiation of each pavement surface. The experimental condition is based on the data on the hottest temperature (August 5, 2005, $34.0^{\circ}C$) of the you. Some of main findings are: 1) The heat environment was worse on the wood pavements than on the stone pavement. This is mainly due to the low albedo of the wood pavements (0.37) while the albedo value of stone pavements is 0.41. Small heat capacity of the wood pavements also contributes to this difference. 2) The heat environment was worse on the stone pavements than on the turf pavements. This was mainly due to the evapotranspiration of the plant growth layer of the turf pavements. 3) The peak surface temperature was the highest on the wood pavements ($56.1^{\circ}C$). The peak surface temperatures on the stone pavements, the stone-grass pavements and the grass pavements were $43.1^{\circ}C,\;40.1^{\circ}C\;and\;37.9^{\circ}C$, respectively. 4) To improve the thermal environments in the urban area, it is recommended to raise the albedo of the pavements by brightening the surface color of the pavement materials. Further studies on the pavement materials and the construction methods which can enhance the continuous evapotranspiration from the pavements surface are needed.

저수형 잔디블록 저수조 내 충진재료에 따른 저수량 및 초종별 증발산량

한승호,최준수,양근모,양병이,강진형,김원태,Han, Seung-Ho,Choi, Joon-Soo,Yang, Geun-Mo,Yang, Byoung-E,Kang, Jin-Hyoung,Kim, Won-Tae 한국조경학회 2006 韓國造景學會誌 Vol.34 No.5

The purpose of this study was to investigate the performance of porous grass block. For the investigation, Festuca arundinacea and Zoysia japonica 'Zenith' were planted, and the volume of evapotranspiration and remains were examined based on different materials in the water tank in the experiment of Festuca arundinacea, the volume of water storage of treatment with perlite ($10.84{\iota}/m^2$) was higher than that with drainage ($7l/m^2$). The difference between the two was $3.84/m^2$. The drainage treatment without water storage capacity showed the higher degree of dryness in turf grass. The volume of evapo-transpiration of treatment with perlite was the highest (21.57mm/week). The volume of evapotranspiration of treatment with sand was 19.57mm/week, and with treatment with drainage was 18.24mm/week. Based on the measured volume of daily evapotranspiration of $2.60{\sim}3.08mm\;d^{-1}$, it was determined that the unit with water storage capacity would store water of one to two days usage compared to unite without such storage capacity. In the experiment of Zoysia japonica 'Zenith', the volume of water storage of treatment with perlite was $10.77l/m^2$ which was similar to the former experiment. The volume of evapotranspiration of treatment with perlite and sand were 21.64mm/week and 20.64mm/week, respectively. In case of airtight water tank, the volume was measured as 22.06mm/week. Each treatment has no notable difference in the volume of evapotranspiration. In conclusion, from the investigation in this study, porous grass block with water tank was found to be effective in plant growth under low irrigation. As the ecological area ratio and vegetated porous pavement have became more emphasized, additional study of rain infiltration and reservoir effect are needed in the future.