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건강한 4개월 영아에서 기흉으로 발현된 거대세포바이러스 폐렴 1예
강동희 ( Dong Hee Kang ),김수연 ( Su Yeon Kim ),김영은 ( Young Eun Kim ),고효정 ( Hyo Jung Koh ),안연화 ( Yeon Hwa Ahn ) 대한천식알레르기학회(구 대한알레르기학회) 2021 Allergy Asthma & Respiratory Disease Vol.9 No.2
Cytomegalovirus (CMV) is the most common agent of congenital infections and opportunistic infections in an immunocompromised host. CMV in an immunocompetent host has inapparent infections, which are usually asymptomatic or cause mild mononucleosis-like symptoms. However, severe CMV diseases, such as pneumonia, hepatitis, gastrointestinal disease, often occur in a healthy infant. The association of CMV pneumonia with the development of pneumothorax has rarely been reported. We experienced a case of CMV pneumonia presenting as pneumothorax in a 4-month-old healthy infant, who was successfully treated with supportive care. CMV was confirmed by using CMV polymerase chain reaction of tracheal aspirates. This case suggested that CMV should be considered as a cause of viral pneumonia during the infant period. (Allergy Asthma Respir Dis 2021;9:104-108)
강동희 ( Dong Hee Kang ),김현수 ( Hyun Soo Kim ) 한국미생물생명공학회(구 한국산업미생물학회) 2011 한국미생물·생명공학회지 Vol.39 No.3
본 연구에서는 중풍, 고혈압, 동맥경화, 염증성 피부질환에 사용되고 있으며, 다양한 질환들에서 연구되어 있는 방풍통성산을 선정하여 4가지 약재를 가미한 후 기존의 기능성 물질과 Lactobacillus 균주에 의해 생성되거나 증가된 기능성 물질을 확인하고자 하였다. 한약을 이용한 복합배양은 공시균주의 수 및 접종시기를 달리하여 여러 조합으로 수행하였다. 전자공여능 및 superoxide dismutase 유사 활성 측정을 통해 한약의 항산화 활성은 각각 31.7%와 36.3%로 나타났으며, 복합배양을 통해 발효된 한약의 항산화 활성은 각각 77% 이상, 42% 이상으로 나타나 한약보다 항산화 활성이 더 높게 나타났다. 항균 활성은 한약의 경우 모든 시험균주에 항균 활성이 나타나지 않았으나, 복합배양 된 한약의 경우에는 B. subtilis PCI 219, P. aeruginosa KCTC 2004, S. aureus subsp. aureus KCTC 1916에 항균 활성을 보였으며, 특히 여드름을 유발시키는 P. acnes KCTC 3314에 항균활성을 보였다. RBL-2H3 세포주에서 알레르기 억제 효과를 확인한 결과 한약은 60% 알레르기 억제 효과를 보였으며, 발효한약은 57% 알레르기 억제 효과를 보였다. 발효한약은 알레르기 억제 효과와 함께 항균 활성과 항산화 활성의 증가로 인하여 알레르기 개선, 피부노화 및 병원성 미생물에 의한 피부질환의 개선에 효과가 있을 것으로 사료된다. Through the process of fermentation with Lactobacillus strains this study has evaluated the functionality of the traditional Korean medicine Bangpungtongsungsan after the addition of four other medicinal ingredients. In order to facilitate the growth of the Lactobacillus strains brown sugar was added to the herbal substances used. For both DPPH radical scavenging activities and SOD-like activities the medicinal mixture, when fermented through heterogeneous co-cultures, scored higher (at 77% and 42%, respectively) than when not fermented (at 31.7% and 36.3%, respectively). The co-cultured Korean medicine inhibited the growth of Bacillus subtilis PCI 219, Pseudomonas aeruginosa KCTC 2004, Staphylococcus aureus subsp. aureus KCTC 1916 and Propionibacterium acnes KCTC 3314. The inhibiting effects on β-hexosaminidase released from RBL-2H3 cells caused by the mixture, with and without fermentation, was seen to be similar (57% and 60%, respectively).
대학 교수자의 교수 전문성 향상을 위한 e-티칭포트폴리오 시스템의 설계 및 개발
강동희 ( Dong Hee Kang ),최명숙 ( Myoung Sook Choi ) 한국교육정보미디어학회(구 한국교육정보방송학회) 2013 교육정보미디어연구 Vol.19 No.3
본 연구의 목적은 대학 교수자의 교수전문성 향상을 위하여 자기 주도적인 수업 개선과 지속적인 성찰을 지원하는 웹 기반의 e-티칭포트폴리오 시스템을 설계?개발하는 데 있다. 본 연구는 웹 콘텐츠 개발 모형을 기반으로 분석, 설계, 개발, 평가의 단계로 진행하였으며 시스템 개발 단계에서는 래피드 프로토타입 개발 방법론을 적용하였다. 우선적으로 시스템의 핵심 기능을 포함한 프로토타입을 개발하고 이에 대한 초기 사용성 평가, 소집단 평가, 현장 평가의 과정을 거치면서 사용자의 요구를 수집하였다. 각 평가 단계별로 수집된 요구는 프로토타입을 개선하는 데 반영하였다. 최종 개발된 시스템은 표준화된 열 개의 구성요소를 제공하는 코스 포트폴리오로서 수업설계 템플릿 제공, 수업 단계별 멀티미디어 자료 연결 기능, 웹 기반 도움말과 사례 제공, e-티칭포트폴리오 공유, 대학의 학사관리시스템과 LMS(학습관리시스템) 연동, 직관적인 인터페이스 등의 특징을 가진다. The purpose of this study was to design and develop a web-based e-Teaching Portfolio System supporting university faculty`s self-directed teaching and continuous reflection for professional development of teaching. This study was conducted by a web contents development model which follows analysis, design, development, and evaluation phases. A rapid prototype development methodology was applied in the phase of development. A prototype with key features of the system was developed and then the needs of users were collected through usability test, small group evaluation, and on-site assessment. Information collected in each evaluation step applied to correct errors and improve the functions of prototype system. The final system features as follows: First, the system consists of standardized ten-components. Second, it is a course portfolio for improvement of teaching rather than career portfolio for employment or promotion. Third, it provides an instructional design template to which teaching materials are linked. Fourth, professors can directly transfer course materials from portfolio to Learning Management System. Fifth. a web-based guide and sample are to help faculty understand the e-teaching portfolio and minimize difficulties and confusion over using the system. Sixth, an intuitive interface makes possible to identify at a glance the status of e-teaching portfolio development.
강동희(Tong Hee Kang) 한국지역학회 1999 지역연구 Vol.15 No.1
It is widely known that optimal control techniques are useful to measure the performance of macroeconomic policy. This paper examines how the methods could be applicable to the regional policy process, and applies them to the evaluation of the public investment expenditures conducted by the local government of Choongbook Province in Korea. The numerical example illustrates the usefulness of the methods for the evaluation of the regional economic policies suggesting the main findings as follows: (1) If the local government of Choongbook Province had increased the public investment expenditures allowing the budget deficits for the first three to four years during the period between 1985 and 1990, its GRDP would have early rise: i to the ratio of more than three percent of Korea`s total GDP. (2) The additional welfare losses incurred by not following the optimal policy were 0.191 in 1986, 0.607 in 1987, 1.585 in 1988, and 0.132 in 1989, indicating that the public investment policy proves to be the best in 1989 and the worst in 1988.
항생제 다제내성균 Pseudomonas aeruginosa에 대한 생육저해물질 생산 방선균의 분리 및 항균활성
강동희(Kang, Dong Hee),배호경(Ho-Kyung Bae),김현수(Hyun-Soo Kim) 한국생물공학회 2011 KSBB Journal Vol.26 No.1
Of the 500 Actinomycetes isolates obtained from soil, one isolate grown on maltose as the sole carbon source produced compound BHK-P19, which inhibited the growth of multiple drug resistant P. aeruginosa 0245. Ultraviolet radiation mutagenesis curtailed production of BHK-P19. Mutation of the BHK-P19 producer using N-methyl-N`- nitro-N-nitroso-guanidine obviated the antibacterial activity to P. aeruginosa 0245, but not towards P. aeruginosa 0225. The mixing of BHK-P19 and BHK-S5 culture extracts inhibited P. aeruginosa 0254, 0225 and 1113. The combined application of BHK-P19 culture extract and Schizandra chinensis Baillon extract inhibited P. aeruginosa 0254, 0225, 0826, 1113, 1378, 1731 and 2492. Use of various concentrations of BHK-P19 culture extract and ampicillin markedly increased antibacterial activity against multi-drug resistant P. aeruginose 1113.
고들빼기 김치의 有機成分(Ⅰ) - 遊離아미노酸에 關하여 -
강동희(Dong Hee Kang),우영숙(Young Sook Woo),이영경(Young Kyoung Lee),정승용(Seung Yong Chung) 한국식품영양과학회 1983 한국식품영양과학회지 Vol.12 No.3
고들빼기를 멸치젓으로 김치담금하여 熟成中의 遊離아미노酸을 分析定量하여 다음과 같은 結果를 얻었다.<br/> 原料 고들빼기의 잎과 뿌리에서 各各 8種의 遊離아미노酸을 定量하였으며, 뿌리에는 arginine, cystine, glutamic acid, 잎에는 arginine, valine, isoleucine, phenylalanine 등의 含量이 많았고 特히 arginine은 잎 뿌리 모두 그 含量이 越等히 많았다. 總 遊離아미노酸量은 잎이 뿌리의 約 2.5倍였다.<br/> 고들빼기 김치에서는 잎, 뿌리 모두 總 15 種의 遊離아미노酸을 檢出 定量하였으며 잎, 뿌리 모두 threonine, glutamic acid, alanine, leucine, cystine의 含量이 많았다. 總 遊離아미노酸量은 김치 잎이 9435.6㎎%, 뿌리는 7079.1㎎%로서 잎이 約 5 倍 뿌리가 約 11倍로서 原料에 比해 많은 增加를 보였다.<br/> 김치 液汁에서는 總 16種의 遊離아미노酸을 定量하였으며 그 中 threonine, glutamic acid alanine, cystine, leucine 등의 含量이 많았다. The change of free amino acids was identified during fermentation of kimchis (Ixeris sonchifoliaH.) added fermented anchovy.<br/> The results were summarized as follows;<br/> In fresh roots and leaves of Ixeris sonchifolia H.,8 kinds of free amino were determined respectively. Among them, argine, cystine and glutamic acid were abundant in fresh roots. while arginine, valine, isoleucine and phenylalanine in fresh leaves, especially arginine was dominant in fresh both roots and leaves. The amount of total amino acids in fresh leaves was about 2.5 times of that of roots.<br/> After fermentation, 15 kinds of free amino acids were determined in kimchis, and the characteristic favor of it was attributed to such amino acids as threonine, glutamic acid, alanine, leucine and cystine, The content of total free amino acids in kimchi leaves was increased to about 5 times of that in fresh (9,435,6㎎ % on dry base), but in kimchi roots, 11 times of that in fresh was contained (7,079, 1㎎ % on dry base)<br/> In kimchi'es extract, 16 kinds of free amino acids were determined, and threonine, glutamic acid, alanine, cystine and leucine were abundant.