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한병훈,김진구,오세진,이상욱,윤병철,장희경,장성훈 대한소화기학회 2000 대한소화기학회지 Vol.35 No.6
Primary biliary cirrhosis with multiple myeloma is very rare, and there have been only 7 case reports in the literature to date. Simultaneous occurrence of primary biliary cirrhosis and multiple myeloma seemed to be related to the hypothesis that chronic antigenemia can result in an expansion of a monoclonal population of B-lymphocytes. The chronic antigenemia is a persistent antigenic stimulation of the reticuloendothelial system, which has been explained through the incapacity of the liver to clear the antigen from the gut. Such clone may be subsequently transformed into a malignant clone by a mutagenic stimulus. We experienced a 52-year-old male patient who had been complaining of generalized pruritus for 9 months. This patient was confirmed to be in early stage of primary biliary cirrhosis complicated by IgG-λtype multiple myeloma. We compared this case with others reported in literatures.
인삼 사포닌의 체내 대사에 관한 연구(I) 동위원소 표지 사포닌의 흡수, 체내 분포 및 배설에 관하여
한병훈,장일무 고려인삼학회 1977 Journal of Ginseng Research Vol.2 No.1
1. 인삼증에 함유된 danlmarane계 glycoside 성분들 중의 한 성분인 panax saponin A(ginsenoside Rgl)(약자 : PSA)에 $^{14}C$ 또는 $^{3}H$를 도입한 방사능 표지 사포닌을 합성하였다. 2. $^{3}H$-PSA의 방사능을 생체내 에서 추적한 결과 PSA는 위장관내에서 쉽게 흡수되어 생체 내 전장기에 골고루 분포된다. 3. 각 장기에 분포된 PSA는 세포 내에 섭취되며 세포 내에 섭취 되는 양은 일정한 포화점이 있다. 4. 포화점을 초과하여 섭취된 PSA는 즉시 뇨를 통하여 배설되며 섭취된 PSA는 세포 내에 장기간 잔유한다. Panax Saponin A(PSA) , one of dammarane glycosides of Korean ginseng, was labeled with $^{3}H$ or $^{14}C$ by our Previously reported Procedures of organic synthesis. Tracer studies with $^{3}H$-PSA in wino yielded the following results: 1). Oral and intraperitoneal administration of $^{3}H$-PSA resulted in the rapid appearance and prolonged retention of $^{3}H$-PSA in all organs such as liver, brain, bone marrow and spleen of mice. 2). The amount pi cellular intake of $^{3}H$-PSA was shown to have a certain level of saturation ranging from 0.4mg to 0. 7mg Per 20gm body weight of mice. Administration of $^{3}H$-PSA within the dosage of the saturation point did net give urinary excretion of 3H-PSA. On the contrary, excessive administration of $^{3}H$-PSA resulted in rapid excretion of the substance in the urine of mice.
한병훈,박명환,우린근,우원식,한용남 ( Byung Hoon Han,Myung Hwan Park,Lin Keun Woo,Won Sick Woo,Yong Nam Han ) 생화학분자생물학회 1979 BMB Reports Vol.12 No.1
This paper is concerned with the studies on the effective components possessing antioxidant activity, with a view to demonstrate the anti-aging activity of Korean ginseng. Feeding the extract of Korean ginseng or its effective component to mice inhibited strongly the lipid peroxidaiion induced by ethanol intoxication. From the; extract of Korean red ginseng, one effective component, Compound A, mp. 143^0 C_6H_6O₃, was isolated by chromatographic purification and its chemical structure was determine! as 3-hydroxy-2-methyl-γ-pyrone (maltol).
한병훈,박만기,이은실,Han, Byeong-Hun,Park, Man-Gi,Lee, Eun-Sil 고려인삼학회 1991 Journal of Ginseng Research Vol.15 No.2
The metabolic fate of ginsenosides including gastrointestinat absorption, organ distribution, excretion and metabolism in liver was investigated by tracer studies using the radio-labeled ginsenosides. 3H-ginsenosides were shown to be absorbed from the mouse digestive tract and then to be excreted rapidly into urine and/or bile. Bile juice was concluded to play a significant role in absorption of ginsenosides. The total concentration of radioactivity persisted in tissues 24 hrs after oral administration was less than 1.3% of the administered dose and Rbl showed the highest value. The concentrations of radioactivity were relatively high in the liver and kidney. After administration of Rbl radioactivity was detected in the brain. After oral administration of 8H-ginsenosides, major component excreted into urine was found to be the intact ginsenosides and decomposed and/or metabolized products were found in GIT in the case of Rbl. 3H-ginsenoside Rbl was shown to be metabolized in the liver and the metabolite was suggested to be an acylated compound of Rbl by a certain organic acid.
트리테르페노이드의 코르티코이드 유사활성물질에 관한 연구 ( 2 ) 11 - 옥소올레아놀산 및 유도체의 합성과 그 항염증 활성
한병훈,조명선,한용남,박명환 ( Byung Hoon Han,Myung Sun Kim - Cho,Yong Nam Han,Myung Hwan Park ) 생화학분자생물학회 1984 BMB Reports Vol.17 No.1
The effect of 11-oxo-oleanlic acid [I] and its derivatives on carrageenin-induced edema in rat kind paw was investigated. The following derivatives were synthesized ; 11-oxo-oleanolic acid methylester [II] C_(31)H_(48)O₄ mp 196-198° was derived from [I] by methylation with CH₂N₂. 3-Oxo-oleanolic acid [III] C_(30)H_(46)O₃, mP 198-202° was obtained from oleanolic acid by CrO₃-pyridine oxidation. Oxidation of [III] by CrO₃-HAc produced 3,11-dioxooleanolic acid [IV] C_(30)H_(46)O₃, mp 268-270° VU (λ max) 252 ㎚ and 3,11-dioxo-oleanolic acid lactone [V] C_(30)H_(44)O₄, mp 265-267° as a by-product. [IV] showed strong competitive inhibition against corticoid-5β-reductase, K_i= 4. 2×10-qM, compared to 4. 6×10^(-4)M of [I]. The anti-inflammatory activities of 11-oxo-oleanolic acid derivatives were evaluated by rat kind paw carrageenin edema test after s.c, injection with 30㎎/㎏ doses. [I], [II], [IVY and [V] suppressed significantly the edema volumes by 63, 78, 70 and 66%, respectively, compared to 66% of hydrocortisone. The above results suggest that the replacement of OH group in C₃ position by ketone group increased the corticomimetic activity, but that the change on the steric structure in C and D rings by lactone formation reduced the activity increase. [II] showed the most powerful activities probably due to increased lipophilicity.