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Aucubin 의 Ribonucleic Acid 생합성 억제작용
장일무,박영춘,윤혜숙 ( Il Moo Chang,Young Choon Park,Hye Sook Yun ( Choi ) ) 생화학분자생물학회 1982 BMB Reports Vol.15 No.3
Aucubin, an iridoid gludoside, was isolated from Aucuba japonica (Cornaeae). One of biological activities of aucubin was found to inhibit RNA biosynthesis in leukemia SN 36 tumor cells in vitro. Aucubin appeared not to possess antitumor activities against leukemia SN 36 murine tumor. The combination therapy with aucubin plus actinomycin D did not show any significant additive or synergistic antitumor activities in comparison with that of actinomycin D alone treatment.
Rhodium ( Ⅱ ) 2 ( Propionate ) 2 L4 가 Ehrlich 암세포 분열에 미치는 영향
장일무,우원식 ( Il Moo Chang,Won Sick Woo ) 생화학분자생물학회 1976 BMB Reports Vol.9 No.3
Rhodium(II)₂ (propionte)₄ L₂ is one of few metalic compounds to exhibit antitumor activity against murine tumors. It was demonstrated that 2.7 ㎎/㎏ of rhodium (II)₂ (propionate)₄ L₂ inhibited DNA synthesis of Ehrlich tumor cells in vivo, whereas 0.3㎎/㎏ of this ccmpound did not. Autoradiographic studies indicated that rhodium(II)₂ (propionate)₄L₂ caused disruption of the cyclic pattern of Ehrlich tumor cell replication. It was observed that rhodium(II)₂ propionate₄L₂ exhibited marked reduction in mitotic indices of Ehrlich tumor cells. Ehrlich tumor cells in G₂ phase appeared to be sensitive to rhodium (II)₂ (propionate)₄ L₂.