“하버드에 가게 됐어!”

金容九(김용구) 관훈클럽 2003 관훈저널 Vol.- No.89

일본 동경도 하수도에 관한 연구(1)

김용구 釜山工業大學校 1978 論文集 Vol.18 No.-

요즘세상-이랜드의 색다른 처방

김용구 우리신학연구소 2007 갈라진 시대의 기쁜소식 Vol.- No.798

관성/확산필터를 이용한 나노입자의 분류기술 연구

김용구,이상열,김한나,노학재,봉춘근,김대성,Kim, Yonggu,Lee, Sangyul,Kim, Hannah,Noh, Hakjae,Bong, Choonkeun,Kim, Daesung 한국입자에어로졸학회 2015 Particle and Aerosol Research Vol.11 No.2

The purpose of this research is to find out the collection property of nanoparticle in diffusion filter to know particle size dispersion of nanomaterial using inertial force and principle of Brownian diffusion motion. We used inertial filters which are two different type and diffusion filters made by various kinds of Wiremesh and the different pieces of filter to compare with particle size distribution using NaCl particles. Finally, We made a conclusion as follows : (1) the bigger available charging volume is and the larger specific surface area of inertial filter is, the better collection efficiency is. (2) The higher wire-mesh number of filter is, the more collection efficiency of small particle is increasing because the wire of the higher Wiremesh number filter is thinner and denser. (3) The more pieces of wire-mesh filter, the more collection efficiency is increasing because it makes the residence time longer.

A Statistical Thermodynamic Study on the Conformational Transition of Oligopeptide Multimer

김용구,박형석,Kim, Yong Gu,Park, Hyeong Seok Korean Chemical Society 1996 Bulletin of the Korean Chemical Society Vol.17 No.2

The conformational transition of oligopeptide multimer,-(HPPHPPP)n-, is studied (H:hydrophobic amino acid, P:hydrophilic amino acid). The helix/coil transitions are detected in the multimer. The transition depends on the number of amino acid in the sequence, the concentration of the oligopeptide, and temperature which affects helix stability constant (${\xi}$) and hydrophobic interaction parameter (wj). In the thermodynamic equilibrium system jA${\rightarrow}$Aj (where A stands for oligopeptide monomer), Skolnick et al., explained helix/coil transition of dimer by the matrix method using Zimm-Bragg parameters ${\xi}$ and $\sigma$ (helix initiation constant). But the matrix method do not fully explain dangling H-bond effects which are important in oligopeptide systems. In this study we propose a general theory of conformational transitions of oligopeptides in which dimer, trimer, or higher multimer coexists. The partition of trimer is derived by using zipper model which account for dangling H-bond effects. The transitions of multimers which have cross-linked S-S bonds or long chains do not occur, because they keep always helical structures. The transitions due to the concentration of the oligopeptides are steeper than those due to the chain length or temperature.

주요우울증에서 사이토카인-세로토닌 상호작용에 의한 신경변성 가설

김용구 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

A growing body of evidence suggests that major depression is associated with increased productions of pro-inflammatory cytokines such as IL-l, IL-6, IL-12 or TNF-alpha and increased concentrations of prostaglandin E2 and negative-regulatory cytokines such as IL-4 or IL-10. In major depression, interactions among brain 5-HT levels, the activity of its autoreceptors, and that of postsynaptic receptors play a critical role in mood changes and depression. Recently, the link between cytokines and serotonergic turnover has been explored. Cytokines such as IL-l, IL-2 and IFN-gamma reduce the production of 5-HT by stimulating the activity of indo1eamine-2,3 dioxygenase (IDO), an enzyme which convert tryptophan, the precursor of 5-HT to kynurenine. The kynurenine is metabolized into quinolinic acid (quinolinate) and kynurenic acid (kynurenate), an excitotoxic NMDA receptor agonist and the antagonist of three ionotropic excitotatory aminoacid receptors, respectively. The Cytokine-serotonin interaction through IDO that leads to the challenge between quinolinate and kynurenate in the brain may finally induce the neurodegeneration in depression. The neurodegeneration hypothesis of depression can explain how people cope with psychological or physical stress at different stages according to severity and duration of stress and why major depression develops.

Diagnostic approaches for inherited hemolytic anemia in the genetic era

김용구,박준홍,김명신 대한혈액학회 2017 Blood Research Vol.51 No.2

Inherited hemolytic anemias (IHAs) are genetic diseases that present with anemia due to the increased destruction of circulating abnormal RBCs. The RBC abnor-malities are classified into the three major disorders of membranopathies, hemo-globinopathies, and enzymopathies. Traditional diagnosis of IHA has been per-formed via a step-wise process combining clinical and laboratory findings. Nowadays, the etiology of IHA accounts for germline mutations of the respon-sible genes coding for the structural components of RBCs. Recent advances in molecular technologies, including next-generation sequencing, inspire us to ap-ply these technologies as a first-line approach for the identification of potential mutations and to determine the novel causative genes in patients with IHAs. We herein review the concept and strategy for the genetic diagnosis of IHAs and pro-vide an overview of the preparations for clinical applications of the new molecular technologies.

번역의 국제정치학 : 마틴과 휘튼

김용구 한림대학교 한림과학원 2008 개념과 소통 Vol.1 No.1

이질 문명권 사이의 번역에는 오해,굴절,선택이 동반된다. 이런 현상에 관해서는 여러 원론적인 견해나 초보적인 이론 구성을 위한 노력들이 있다. 그러나 그런 현상을 번역의 역사적 현장에서 분석한 업적은 그리 흔하지 않다. 이 논문은 1864년 마틴(W.A.P. Martin)이 휘튼{H. Wheaton)의 국제법 저서를 한역하면서 나타난 위의 현상들을 분석한 글이다. 이 과정에서 휘튼의 저서를 사대질서의 회전(會典)으로 오해 했다. 이것은 유럽 국제사회와 사대질서를 혼동한 결과이다. 휘튼의 저서는 실증법적인 연구인데,마틴이 자연법적인 색채를 가미해 굴절하여 번역했다. 자연법적인 전통을 지닌 조선과 중국의 지식인들에게 크게 영항을 미치게 된 원인이다. 휘튼의 저서는 유럽 공법의 지식이 없던 동양의 지식인에게는 난해했기 때문에 선택이 뒤따르게 되었다. 결과적으로 독립,균세, 자주와 같이 필요한 개념만을 수용하게 되었다. 이처럼 오해,굴절,선택을 동반한 번역으로는 유럽 국제정치의 본질을 파악할 수는 없다. 오늘날 한국의 국제정치학은 기본적으로 이런 번역의 국제정치학 수준에 머물고 있다. As a specific case of communication across heterogeneous civilizations, translation entails unique cultural phenomena, characterized as misunderstanding, distortion, and selection. While various perspectives and studies have attempted to theorize such phenomena, they have remained largely at an abstract level. We need to move beyond general discussions, so that, by placing the issue in the context of concrete history, and employing textual analysis, we may trace the processes and the consequences of translation. Focusing on W.A.P. Martin's 1864 Chinese translation of H. Wheaton's Elements of International Law, this paper, therefore, analyzes the phenomena of misunderstanding, distortion, and selection that originated in cross-civilization translation. Wheaton's work was written from a thoroughly positivistic viewpoint, the dominant paradigm of international law in Europe, at the time. In the absence of any knowledge of European public law, however, it was difficult for Choso˘n intellectuals, or for their Chinese counterparts, to understand various key concepts of international law that Wheaton presented. Knowing this when he translated Wheaton's work into Chinese, Martin altered the nature of the original text by adding natural law elements, which were familiar to Choso˘n and Chinese intellectuals. As such, this translated Chinese version greatly influenced East Asian intellectuals, who were deeply entrenched in the natural law tradition. Yet, this sort of distortion in translation resulted in misunderstanding and selection, Viewing their subject-matter through the distorted lens of translation, Choso˘n and Chinese intellectuals failed to identify the essential differences between European public law and Sadae order, as shown by the fact that they treated Wheaton's work as if it were the statute of Sadae order. Moreover, due to the ensuing selection of ideas, Choso˘n and Chinese intellectuals accepted only the concepts they needed, such as independence, balance of power, and autonomy, a reaction which sheds light on one important lesson: that translation accompanied by the phenomena of misunderstanding, distortion, and selection inhibited a proper appreciation of the fundamental nature of Euro-centric international politics.

Bayesian estimation in the generalized half logistic distribution under progressively type-II censoring

김용구,강석복,서정인 한국데이터정보과학회 2011 한국데이터정보과학회지 Vol.22 No.5

The half logistic distribution has been used intensively in reliability and survival analysis especially when the data is censored. In this paper, we provide Bayesian estimation of the shape parameter and reliability function in the generalized half logistic distribution based on progressively Type-II censored data under various loss functions. We here consider conjugate prior and noninformative prior and corresponding posterior distributions are obtained. As an illustration, we examine the validity of our estimation using real data and simulated data.

Bayesian estimations on the exponentiated half triangle distribution under Type-I hybrid censoring

김용구,강석복,서정인 한국데이터정보과학회 2011 한국데이터정보과학회지 Vol.22 No.3

The exponenetiated distribution has been used in reliability and survival analysis especially when the data is censored. In this paper, we derive Bayesian estimation of shape parameter and reliability function in the exponenetiated half triangle distribution based on Type-I hybrid censored data. Here we consider conjugate prior and nonin-formative prior and obtained corresponding posterior distributions. As an illustration, the mean square errors of the estimates are computed. Comparisons are made between these estimators using Monte Carlo simulation study.