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불특정한 소화기계 증상으로 응급실에 방문한 소아에서의 혈청 Helicobacter pylori lgG 검사가 유용한가?
신종환,류일,이근,양혁준,임용수,김재광,류지호 대한응급의학회 2002 대한응급의학회지 Vol.13 No.4
Purpose: Children visit the emergency department (ED) with more severe abdominal pain, nausea, and vomiting without specific cause than any other outpatients, and many have recurrent abdominal pain (RAP). For that reason, we examined the correlation between Helicobacter pylori (H. pylori) infection and these symptoms. Methods: From August 2001 to January 2002, serum samples of H. pylori IgG were collected prospectively from 90 children under 17-years old who had visited out ED with the above symptoms. Of these, 40 children satisfying Apley's criteria were researched. H. pylori infection was defined as a positive result on a CLO test or a C13-Urea Breath test or a modified Giemsa stain. Results: The male-to-female ratio was 1.5 : 1, and the mean age was 8.6±3.9 years old. The mean value of the IgG level was 16.1±22.2 U/mL. Seropositive patients accounted for 11 cases (28%). Of the 30 children who had undergone upper endoscopy, 15 children were confirmed as having an H. pylori infection. The sensitivity and the specificity of H. pylori IgG were 47% and 73%. In the school-age group (≥8 years old), the rates of IgG positivity and infection were 42% (10/24) and 70% (14/20), compared with the preschool age group value of 6% (1/16) and 10% (1/10). The most common upper endoscopy findings was nodular gastritis in 23 patients. Conclusion: The rate of H. pylori infection in children visiting the ED with unknown causes of above symptoms was higher than it was in a recent study. In ED, H. pylori IgG may be required as a screening test in such children.
신종환,김경수,한준희 한국유전학회 2014 Genes & Genomics Vol.36 No.6
Transcriptional regulation is a complex processmediated by coordinated assembly complexes to ensuretemporal and spatial gene expression. The AT-hook is aDNA-binding motif originally described in the highmobility group A of non-histone chromatin components. The AT-hook proteins bind to the minor groove of adenine–thymine (AT) rich regions of DNA and act as transcriptionalcofactors coordinating nucleoproteins duringtranscriptional regulation. In this study, a genome-wide insilico analysis of AT-hook proteins was performed on theascomycete plant pathogenic fungus, Magnaporthe oryzae. Quantitative real-time RT-PCR analysis revealed differentialexpression patterns of MoATH genes during developmentand plant infection. To increase our understandingof the functional role of AT-hook proteins in M. oryzaedevelopment and pathogenicity, a deletion mutant of Mo-ATH10 was functionally characterized. Targeted deletionof MoATH10 significantly increased pigmentation andconidiation, indicating that MoATH10 is negativelyinvolved in the regulation of pigmentation and conidiationin M. oryzae. Pathogenicity assays revealed that theDMoath10 mutant was less virulent. The reduced diseasedevelopment of the DMoath10 mutant was due to a partialdefect in invasive growth inside plant cells, but notappressorium-mediated penetration. These results suggestthat MoATH10 is important for growth, development, andvirulence in M. oryzae.