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A Personalized and Learning Approach for Identifying Drugs with Adverse Events
신선균,권영옥,허호,천은경,오옥희,이정선,고우진,김범석 연세대학교의과대학 2017 Yonsei medical journal Vol.58 No.6
Purpose: Adverse drug events (ADEs) are associated with high health and financial costs and have increased as more elderly patientstreated with multiple medications emerge in an aging society. It has thus become challenging for physicians to identify drugs causing adverse events. This study proposes a novel approach that can improve clinical decision making with recommendations on ADE causative drugs based on patient information, drug information, and previous ADE cases. Materials and Methods: We introduce a personalized and learning approach for detecting drugs with a specific adverse event, where recommendations tailored to each patient are generated using data mining techniques. Recommendations could be improvedby learning the associations of patients and ADEs as more ADE cases are accumulated through iterations. After consulting the system-generated recommendations, a physician can alter prescriptions accordingly and report feedback, enabling the systemto evolve with actual causal relationships. Results: A prototype system is developed using ADE cases reported over 1.5 years and recommendations obtained from decision tree analysis are validated by physicians. Two representative cases demonstrate that the personalized recommendations could contribute to more prompt and accurate responses to ADEs. Conclusion: The current system where the information of individual drugs exists but is not organized in such a way that facilitates the extraction of relevant information together can be complemented with the proposed approach to enhance the treatment of patientswith ADEs. Our illustrative results show the promise of the proposed system and further studies are expected to validate its performance with quantitative measures.
申琁均 청주대학교 대학원 1999 우암논총 Vol.21 No.-
Park Noh-shik as a poet of colonial period by Japan tried to express his inner truth through H a h of Japan. Of course, he was misunderstood as a pro-Japanese. But I was able to know that he loved his family, his hometown M o b , and his nation. If we think Park Noh-shik of as the pro-Japanese, we are doubtful of what s h d we explain the Hansi(chinese poetry) by literary men in Chosun dynasty. This paper has a significance of being interested in Haiku by Park Noh-shik, a korean, who was equal to a native Japanese.
MB-OFDM 시스템을 위한 Low-rank LMMSE 채널 추정 및 주파수 옵셋 추정 결합 기법
신선경(Sun-Kyung Shin),남상균(Sang-Kyun Nam),성태경(Tae-Kyung Sung),곽경섭(Kyung-Sup Kwak) 한국통신학회 2007 韓國通信學會論文誌 Vol.32 No.12A
본 논문에서는 MB-OFDM 시스템에 적합한 낮은 복잡도의 채널 및 주파수 옵셋 결합 추정법을 제안한다. 제안된 기법은 적절한 랭크(rank) 수를 적용함으로써 복잡도를 낮추는 Low-rank LMMSE 채널 추정법을 이용하여 채널을 추정하고, 주파수 옵셋 추정을 위해 추정된 채널의 자기상관특성을 이용하는 간단한 구조를 추가함으로써 낮은 복잡도로 채널과 주파수 옵셋을 결합하여 추정하는 기법이다. 제안된 알고리즘을 IEEE 802.15 TG3a에서 제시한 4가지 UWB 채널 모델에서 모의 실험하여 기존의 LS 채널 추정법을 사용한 알고리즘과 성능을 분석하였고, 복잡도를 낮추기 위해 각 채널 모델 환경에 따라 적절한 수의 랭크 수를 적용하여 결과를 비교하였다. In this paper, we propose joint estimation methods of carrier offset and channel estimation for MB-OFDM system with low complexity. The proposed methods estimate the channel by using low-rank LMMSE channel estimation which reduces the system complexity by applying the optimal number of rank to evaluate the frequency offset and additionally using the simple algorithm using the auto-correlation property of the estimated channel. We simulate the proposed algorithms under the IEEE 802.15 TG3a UWB channel model.
다중로지스틱 회귀모형을 이용한 구강건강관련 삶의 질과 사회경 제적위치의 연관성 분석
신선정 ( Sun Jung Shin ),정원균 ( Won Gyun Chung ),안용순 ( Yong Soon Ahn ),마득상 ( Deuk Sang Ma ),박덕영 ( Deok Young Park ),정세환 ( Se Hwan Jung ) 대한예방치과·구강보건학회 2011 大韓口腔保健學會誌 Vol.35 No.3
Objectives. The study assessed the association between socio-economic status (SES) and oral health-related quality of life (OHRQoL) for elderly Koreans, and determined the role of oral health status, oral health behaviors and general health status on this association using multi-variate logistic regression models. Methods. The study population was elderly (≥65-years-of-age) residents of Wonju-City, Gangwon province recruited from five elder welfare institutions. Education level and household income were selected as measures of SES. To assess socio-economic inequalities in OHRQoL, multi-variable logistic regression models were used. A model adjusting for socio-demographic factors (Model I) was compared to models additionally adjusting for oral health behaviors (Model II), oral health status (Model III), general health status (Model IV) and all factors (Model V). Results. One hundred fifty nine people were invited to participate, and the response rate was 97.5% (n=155). Lower SES was significantly associated with lower score of OHRQoL. Oral health behaviors, oral health status and general health status explained part of the social inequalities in OHRQoL. The social gradient score of OHRQoL persisted when adjusted for oral health behaviors, oral health status and general health status. Conclusions. An association between SES and OHRQoL was evident for elderly Koreans. Oral health behaviors, oral health status and general health status were factors affecting the association. Longitudinal research is required to determine the specific role of the association between SES and OHRQoL.
Competencies for Entry into the Profession of Dental Hygiene
배수명,정원균,장종화,문소정,신보미,신선정 한국치위생과학회 2017 치위생과학회지 Vol.17 No.3
This study was conducted to derive core and detailed competencies of dental hygienists to be utilized as educational targets to be reached by graduation as well as basic data that can be reflected in the development and improvement of dental hygiene curricula. This study analyzed publication reports from the Korean Dental Hygienists Association, the International Federation of Dental Hygienists, the Commission on Dental Accreditation, and the American Dental Education Association. Based on the academic classification system for dental hygiene studies, the components of core and detailed competencies of dental hygiene school at the time of graduation were extracted and developed through expert panel discussions. This study defined competencies at the graduation level of dental hygiene school and derived eight core competencies and their 52 detailed competencies to serve as educational objectives from four areas: professionalism, communication, clinical practice, and community and health promotion. In the future, it will be necessary to conduct self-assessments of competencies based on those developed in this study, at time of the graduation from dental hygiene school, as well as to continuously develop competency-based curricula according to entry level, knowledge level, and graduation level. Thus, it is urgently necessary to develop a system that can evaluate the competencies of dental hygienists after graduation and put this system into practical use.