Naloxone이 손상척수의 Cytochrome Oxidase 활성과 사립체 미세구조에 미치는 영향

서중근,주정화 대한신경외과학회 1986 Journal of Korean neurosurgical society Vol.15 No.4

Impact injuries to the surgically exposed dura overlying the lumbar cord at L2 were produced in cats. Cytochrome oxidase activities in frozen-dried sample of spinal cord gray matter were measured and analyzed as a step in the investigation of the possible effects of spinal cord trauma on mitochondria. As conservative index of mitochondrial damage in gtay matter resulting from inactivation on cytochrome oxidase activity, electron microscopic studies of mitochondrial ultrastructural changes in traumatized gray matter were performed. The effects of Naloxone on the alteration of the cytochrome oxidase activities and ultrastructures of the mitochondria in the gray metter were studied. A drop in cytochrome oxidase activities to approximately 50% of normal value was found as early as 15 minutes post-trauma, which greatest decrease at 1/2 hour and 1 hour post-trauma. Ultrastructural changes of the mitochondria continued to proceed with the lapse of time after the injury. Mitochondriae were slightly enlarged with decreased number of cristae at 15 minutes post-trauma. Enlargement of the mitochondria with disintegration of cristae and electron-lucent area in the matrices were observed at 1 hour and 4 hour post-trauma. As relatively less change to the mitochondrial ultrastructures was observed in the Naloxone-treated group than in the non-treated group, the results of this study suggest that Naloxone confers beneficial effects in enhancing the cytochrome-oxidase activity and preserving the mitochondrial ultrastructures from injury.

양측성 Persistent Primitive Trigeminal Artery를 동반한 Cerebral Rete Mirabile 1예

서중근,주정화,이기찬,김성학 대한신경외과학회 1978 Journal of Korean neurosurgical society Vol.7 No.1

A man with bilateral primitive persistent trigeminal artery combined with cerebral rete mirabile is reported. Direct both common carotid artery angiogram is described with a brief discussion of the embryogenesis of carotid-basilar anastomosis and cerebral rete mirabile. Associated findings of previously reported cases of persistent trigeminal artery and cerebral rete mirabile are briefly reviewed. Persistent of the bilateral trigeminal artery associated with hemorrhage from cerebral rete mirabile seems worthy of notation. The angiographic findings were as follows; 1) The characteristic angiographic findings are bilateral occulsion at the cavernous portion of internal carotid artery. 2) Retrograde filling of middle cerebral artery from the collateral anastomotic channel was showed. 3) Anterior and posterior cerebral arteries are filled from leptomeningeal anastomotic channel and cerebral rete anastomosis. Authors suggested that the persistent trigeminal artery is congenital origin and cerebral rete mirabile may suspect to be the secondary change.

수소연료 중의 메탄에 의한 고분자전해질 연료전지 성능변화 연구

서중근,권준택,김준범,정종태,김우식 한국수소및신에너지학회 2007 한국수소 및 신에너지학회논문집 Vol.18 No.4

The reforming process for hydrogen production generates some impurities. Impurities in hydrogen such as CO2, CO, H2S, NH3 affect fuel cell performance. It is well known that CO generated by the reforming process may negatively affect performance of cell, cause damage on catalysts resulting performance degradation. Hydrogen produced by reforming process includes about 2% methane. The presence of methane up to 10% is reported negligible degradation in cell performance. However, methane more than 10% in hydrogen stream had not been researched. The concentration of impurity supplied to the fuel cell was verified by gas chromatography (GC). In this study, the influence of CH4 on performance of PEM fuel cell was investigated by means of current vs. potential experiment, long run (10 hr) test and electrochemical impedance measurement when the concentrations of impurities were 10%, 20% and 30%.

뇌압박과 두개강 내압항진 : 조직학적 연구 Histological study

徐中根 고려대학교 의과대학 1978 고려대 의대 잡지 Vol.15 No.3

Brain compression was experimentally induced in rabbits by an expansion of supratentorial epidural laminaria which is used in gynecological practice to dilate uterine cervical canal and has specific nature of increase in its volumn on contact with water. Histological studies were carried out on the compressed brain tissue. Cerebral edema occured in response to the cerebral compression. Findings of generalized and regional cerebral edema were macroscopically observed in the compressed brain. The white matter was increased more in bluk than in the gray matter and looked wet and often slightly yellow. Histopathological picture of the brain under the compression revealed several different degree of cerebral damage according to the sequence of time. In the group of 12 hour's compression, there were areas of detachment of the meninges. Vascular congestion and edema of the plexiform layer and a moderate degree of chromatolysis of neuronal cell and mild gliosis in the moleculogranular layer. In the group of 24 hour's compression, a thicking of the meninges due to exudative inflammatory reaction was observed. Underlyin plexiform layer disclosed rather prominent gliosis and the moleculogranular layer showed a mild chromatolysis. In the group of 48 hour's compression, the lesion revealed rather marked acute exudative inflammatory change of the meninges. Underlyin plexiform layer was atrophic with gliosis, and moleculogranalar layer showed rather marked chromatolysir of neuronal cell with mild multifocal infiltration of neutrophil and congestion. The cerebrovascular architecture in various portions of the brain compressed by the mass was asessed by intravaseular staining with benzidinoe. Complate collapse and thrombosiss of large surface and perforating vessel immediately subjacent to the mass were prominent. The hemorrhage and severe capillary obliteration of underlying compressed brain substance was also observed.

두개저함입증 (Basilar Impression)의 수술치험 1예

서중근,주정화 대한신경외과학회 1987 Journal of Korean neurosurgical society Vol.16 No.2

A case of basilar impression surgically treated in a female patient aged 22 years is presented. A. myriad of abnormal neurologic findings were present that were secondary to compression of neural tissue by anomalous bony structure at craniovertebral Junction. Metrizamide computerized tomography with coronal and sagittal reconstruction identified bony abnomalities and displacement of the surrounding neural structures. The surgical intervention for the treatment of the basilar impression consisted of ventral decompression by transoral odontoidectomy and of dorsal decompression by an enlargement of foramen magunm and by laminectomy of C₁, followed by occipito-atlanto-axial bony fusion.

뇌압박과 두개강 내압항진

徐中根 고려대학교 의과대학 1978 고려대학교 의과대학 잡지 Vol.15 No.3

연료중의 이산화탄소 불순물에 의한 고분자전해질연료전지의 성능변화 연구

서중근,권준택,김준범,Seo, Jung-Geun,Kwon, Jun-Taek,Kim, Jun-Bom 한국전기화학회 2008 한국전기화학회지 Vol.11 No.1

연료전지는 수소를 직접 사용하는 것이 가장 효율이 높지만 가정이나 사무실에서는 수소 저장탱크를 사용하기보다는 도시가스(메탄가스)를 연료 source로 하여 수소를 생산하는 것이 유리하다. 연료전지에 사용하는 수소는 천연가스나 바이오가스, 탄화수소계열의 연료를 개질하여 생산하며 개질반응과정에서 필연적으로 여러 성분의 불순물이 포함되어 있다. CO, $CO_2$, $H_2S$, $NH_3$, $CH_4$등의 불순물이 포함된 수소연료가 PEM fuel cell에 공급되면 연료전지 성능에 영향을 준다고 보고되어 있다. 이러한 영향에는 전극 촉매의 피독에 의한 kinetic losses, 전해질막과 촉매이온층의 양이온 전도성 감소에 의한 ohmic losses 그리고 촉매층의 구조나 소수성 감소에 의한 mass transport losses가 있다. 개질기에서 생산된 수소연료는 약 73%의 $H_2$와 20% 이하의 $CO_2$, 5.8% 이하의 $N_2$, 2% 이하의 $CH_4$, 10ppm 이하의 CO로 최종 공급된다. 본 연구에서는 연료 중에 $CO_2$가 고분자전해질 연료전지 anode측 성능에 미치는 영향을 조사하였다. 실험은 연료전지에 공급되는 연료중에 $CO_2$농도를 10%, 20%, 30%로 전류와 전압의 성능곡선과 장시간(10시간)실험 그리고 임피던스를 측정하였다. 또한 가스크로마토그래피를 이용하여 순수한 수소와 $CO_2$가 함유된 수소의 혼합을 통해 나온 연료전지 inlet에서의 불순물의 농도를 검증하였다. Even though fuel cell have high efficiency when pure hydrogen from gas tank is used as a fuel source, it is more beneficial to generate hydrogen from city gas (mainly methane) in residential application such as domestic or office environments. Thus hydrogen is generated by reforming process using hydrocarbon. Unfortunately, the reforming process for hydrogen production is accompanied with unavoidable impurities. Impurities such as CO, $CO_2$, $H_2S$, $NH_3$, $CH_4$, and $CH_4$ in hydrogen could cause negative effects on fuel cell performance. Those effects are kinetic losses due to poisoning of the electrode catalysts, ohmic losses due to proton conductivity reduction including membrane and catalyst ionomer layers, and mass transport losses due to degrading catalyst layer structure and hydrophobic property. Hydrogen produced from reformer eventually contains around 73% of $H_2$, 20% or less of $CO_2$, 5.8% of less of $N_2$, or 2% less of $CH_4$, and 10ppm or less of CO. This study is aimed at investigating the effect of carbon dioxide on fuel cell performance. The performance of PEM fuel cell was investigated using current vs. potential experiment, long run(10 hr) test, and electrochemical impedance measurement when the concentrations of carbon dioxide were 10%, 20% and 30%. Also, the concentration of impurity supplied to the fuel cell was verified by gas chromatography(GC).

경추간판 탈출증의 수술과 합병된 중심성 척수 증후군

서중근,임창수,주정화,이기찬 대한신경외과학회 1978 Journal of Korean neurosurgical society Vol.7 No.1

We have recently managed a patient, 31-year-old male, who has been in the state of inferior paraparesis due to cervical disc herniation. The centrally herniated disc material was removed through the posterior approach to the lesion under the general anesthesia in left lateral position. Two days after the operation with removal of herniated disc at C5-6 interspace, the subject developed quadripareis and difficulty in urination in which the weakness of upper extremities were more severe that of the lower extermities. The signs developed postoperatively were very much compatible with those of central cord syndrome. There was improving after the removal of the hematoma and of additional herniated material at second operation which was forced to be done due to development of central cord syndrome in severe degree following the primary surgery. Recovery from neurological dysfunction in order of good and better improvement was of leg, arm, voiding and finger.

연료중의 이산화탄소 불순물에 의한 연료전지 성능변화 연구

서중근(Seo, Jung-Geun),권준택(Kwon, Jung-Taek),김준범(Kim, Jun-Bom) 한국신재생에너지학회 2007 한국신재생에너지학회 학술대회논문집 Vol.2007 No.11

Hydrogen could be produced from any substance containing hydrogen atoms, such as water, hydrocarbon (HC) fuels, acids or bases. Hydrocarbon fuels couold be converted to hydrogen-rich gas through reforming process for hydrogen production. Even though fuel cell have high efficiency with pure hydrogen from gas tank, it is more beneficial to generate hydrogen from city gas (mainly methane) in residential application such as domestic or office environments. Thus hydrogen is generated by reforming process using hydrocarbon. Unfortunately, the reforming process for hydrogen production is accompanied with unavoidable impurities. Impurities such as CO, CO₂, H₂S, NH₃, and CH₄ in hydrogen could cause negative effects on fuel cell performance. Those effects are kinetic losses due to poisoning of electrode catalysts, ohmic losses due to proton conductivity reduction including membrane and catalyst ionomer layers, and mass transport losses due to degrading catalyst layer structure and hydrophobic property. Hydrogen produced from reformer eventually contains around 73% of H₂, 20% or less of CO₂, 5.8% of less of N₂, or 2% less of CH₄, and 10ppm or less of CO. Most impurities are removed using pressure swing adsorption (PSA) process to get high purity hydrogen. However, high purity hydrogen production requires high operation cost of reforming process. The effect of carbon dioxide on fuel cell performance was investigated in this experiment. The performance of PEM fuel cell was investigated using current vs. potential experiment, long run (10 hr) test, and electrochemical impedance measurement when the concentrations of carbon dioxide were 10%, 20% and 30%. Also, the concentration of impurity supplied to the fuel cell was verified by gas chromatography (GC).

6㎾마이크로가스열병합발전시스템 건물적용실증연구

서중근(J.G. Seo) 대한전기학회 2005 대한전기학회 학술대회 논문집 Vol.2005 No.11