태생 전 임신 15일째 Methylazoxymethanol에 노출된 쥐의 수면각성주기 이상 및 신경생리학적 이상

김정일(Jung Il Kim),장수민(Su Min Chang),박성파(Sung-Pa Park),장일성(Il-Sung Jang),최병주(Byung-Ju Choi),김상헌(Sang Heon Kim),이호원(Ho-Won Lee),이만기(Maan Gee Lee) 대한생물치료정신의학회 2006 생물치료정신의학 Vol.12 No.2

뇌 발육이상 중 신경이주장애(neuronal migration disorder)에 의해 나타나는 비정상적인 피질 층 구조는 난치성 간질과 발달장애, 정신지체, 행동 및 정서장애 등과 관련 있다고 알려져 있다. 본 연구에서는 태생기 MAM에 노출시켜 신경이주장애를 유발시킨 쥐에서 수면 이상과 뇌파 이상을 수면-각성 상태의 주기의 관찰과 각 상태에서 뇌파의 정량적 기술을 이용하여 살펴보았다. 그리고 신경이주장애와 관련된 질환에 동반되어 생길 수 있는 수면 이상 및 뇌파 이상을 고찰하였다. MAM 노출 동물에서 역설수면 기간이 정상 동물과 비교할 때 유의하게 감소되었으나 다른 수면 각성 상태의 기간들의 유의한 변화는 없었다. 전체 7시간 관찰(10:30-17:30) 동안 MAM 노출 쥐에서는 전두피질, 중앙피질, 두정피질에서 저명한 진폭 스펙트럼의 변화가 관찰되었다. 특정 뇌영역의 기능 상태를 나타내는 진폭분포스펙트럼 비교에서 모든 피질 영역의 쎄타 파가 MAM 노출 쥐에서 정상 쥐에서보다 감소되었다. 반대로 역설수면 동안 정상 쥐에서 두정부에서 저명한 쎄타 활동이 관찰되지만 MAM 노출 쥐에서는 진폭이 작고 빠른 쎄타파가 관찰되고, 정상 동물의 전두피질에서 쎄타 및 느린 주파수의 쎄타가 관찰되는 반면 MAM 노출 쥐에서는 알파 대역의 빠른 주파수의 방추형파가 기록되었다. MAM 처리된 쥐들에서 나타나는 활동성의 증가와 수면 지연 등의 결과를 고려해 볼 때, 발달동안의 유발된 피질의 기형은 수면 각성의 특성을 변화시킬 뿐만 아니라 전반적인 기능의 이상을 가져옴을 시사한다. Several neuropsychiatric disorders, including intractable epilepsy, mental retardation or schizophrenia, are consequences of cortical malformation. We examined the sleep-wake profiles and the electroencephalographic(EEG) abnormalities in the adult rats exposed to methylazoxymethanol acetate(MAM) at embryonic day 15 whether cortical disorganization could affect sleep-wake cycle and neurophysiological characteristics. In the MAM-exposed rats, only the duration of the paradoxical sleep(PS) decreased significantly while the durations of other sleep-wake states did not differ from the normal control group. The amplitude spectrum of the 7-hour EEG recordings(10:30-17:30) of the frontal, central and parietal cortices of the MAM-exposed group was compared with that of the control group. A significant amplitude decrease was seen in high delta and theta bands of the frontal EEG, in the theta band of the central EEG and in from the delta to low beta ranges of the parietal EEG. The relative amplitude distribution spectrum, which represents a specific functional state of the brain, of the MAM-exposed rats was compared with that of the control group. Significant decrease of the percentage of amplitude was seen in the theta band of the frontal, central and parietal EEG. Conversely, significant increase was seen in the beta band of the central EEG and in the beta and low gamma bands of the parietal EEG. The peak frequency of the theta wave, which is prominent in the parietal EEG, was higher in MAM-exposed rats than in the control group. In visual inspection of the EEG trace of the MAM-treated rat, spindle rhythms of the beta range were prominent during the transition to PS, the PS and even during the slow wave sleep and delta wave amplitude was smaller and the theta frequency was faster as compared with the control group. These observations correspond to the changed in the percentage of amplitude in the relative distribution spectrum. Taken together, the findings suggest that the cortical malformation during development produces an alteration in the global functional state indicated by the EEG changes as well as alters the sleep-wakefulness characteristics.

유암에서 유방보존 수술(Quadrantectomy) 및 액와 청소술

장일성(Eil Sung Chang),김영일(Young Il Kim) 대한외과학회 1993 Annals of Surgical Treatment and Research Vol.44 No.3

유암에서 FAC Regimen을 이용한 Inductive Chemotheraphy 효과

장일성(Eil Sung Chang),김영일(Young Il Kim),노승무(Seung Moo Noh),배진선(Jin Sun Bae),손기섭(Ki Sub Son) 대한외과학회 1993 Annals of Surgical Treatment and Research Vol.44 No.4

외상성 횡격막 손상 치험 11례

이영,장일성,김인구,배진선,손기섭,Lee, Young,Chang, Il Sung,Kim, In Koo,Bae, Jin Sun,Son, Ki Sub 대한흉부심장혈관외과학회 1976 Journal of Chest Surgery (J Chest Surg) Vol.9 No.2

Eleven cases of traumatic diaphragmatic injuries were treated at the department of Surgery from Jan. 1972 to Nov. 1976 were reviewed in this study. 1. Sex ratio of the observed patients was 10 : 1 showing definitely high incidence male patients. 2. The age distribution in this series ranged from 4 to 49 years of age, and average age was 26 years age. 3. Seven cases were received blunt injury on lower chest and upper abdomen, three cases were stabbed by knife and gunshot injury case was on case 4. Six cases were diagnosed and treated early post-traumatic stage within 24 hours, three cases were repaired within I0 days, and the last case was repaired after 5 years post-trauma. 5. The operative mortality was 10% (1/10), the cause of death was liver failure, after right lobectomy of the liver for traumatic liver rupture.

무지 외반증의 치료에서 단일 나사못을 이용한 근위 중족골 쐐기 절골술

최재열,신헌규,장일성,강동호,Choi, Jae-Yeo,Shin, Hun-Kyu,Chang, Il-Sung,Kang, Dong-Ho 대한족부족관절학회 2005 대한족부족관절학회지 Vol.9 No.1

Purpose: We conducted this study to examine the clinical results of the proximal metatarsal wedge osteotomy using a single screw fixation and the distal soft tissue procedure in patients with moderate to severe hallux valgus deformity. Materials and Methods: Between February 2002 and February 2004, we performed these procedures on 12 patients (15 cases). The 6 cases of all patients had mild to moderate instability in the first MTC (metatarsocuneiform) joint. We estimated the clinical outcomes, the radiological findings and complications. Results: AOFAS score was improved from preoperative 41.5 points to 87.7 points lastly on average. The mean correction angle of HVA and IMA was $23.8^{\circ}$ and $6.6^{\circ}$, respectively. The mean position of tibial sesamoid was 2.67 before surgery and 0.87 after surgery. The mean shortening of the first metatarsal bone was 3.07 mm after surgery. There was no pain and complications on the first MTC joint except the breakage of screw in one case and instability of the first MTC joint was improved postoperatively. Conclusion: We obtained good clinical and radiographic outcomes in our series. So, proximal metatarsal wedge osteotomy using a single screw fixation and distal soft tissue procedure seems one of the good surgical treatments for moderate hallux valgus deformity.

조기위암의 임상적 고찰

김영일(Young-Il Kim),장일성(Eil-Sung Chang) 대한외과학회 1992 Annals of Surgical Treatment and Research Vol.43 No.3

무지외반증 치료에서 근위 중족골 절골술과 원위 연부조직 교정술 후 종자골의 교정정도

정화재,신헌규,장일성,이종근,Jung, Hwa-Jae,Shin, Hun-Kyu,Chang, Il-Sung,Lee, Jong-Keun 대한족부족관절학회 2005 대한족부족관절학회지 Vol.9 No.1

Purpose: A retrospective review of the radiographs of the proximal metatarsal osteotomy and distal soft tissue procedure for hallux valgus, evaluating the correction of the tibial sesamoid, was undertaken. We evaluated the correlation between the reduction of the tibial sesamoid and the clinical outcomes. Materials and Methods: 17 patients (23 cases) with moderate to severe hallux valgus deformity underwent the proximal metatarsal osteotomy and distal soft tissue procedure. The preoperative and last follow-up radiographs were reviewed according to the tibial sesamoid grade classification recommended by the Research Committee of the American Orthopedic Foot and Ankle Society (AOFAS). We divided them into two groups according to the reduction of the tibial sesamoid. We anaylyzed the clinical outcomes in each group according to Mayo Clinic Forefoot Scoring System (FFSS). Results: In all of the patients, the preoperative tibial sesamoid position were grade 2 or greater. At the last follow-up, 52% (n=12) were grade 1 or less (Group I) and 48% (n=11) were grade 2 or greater (Group II). In group I, the forefoot score was improved from preoperative mean value of 32.0 points to final follow-up value of 66.3 points. In group II, the forefoot score was improved from preoperative mean value of 31.7 points to final follow-up value of 65.9 points. There was no statistical significance between postoperative, average scores in group I and II (p>0.05). Conclusion: The position of the tibial sesamoid was corrected insufficiently in almost half of all cases. In view of clinical outcomes, there was no significant difference between the corrected group and the other group.

先天性 巨大結腸의 臨床的 硏究

金鎭會(Jin Hue Kim),張一成(Il Sung Chang),孫基燮(Ki Sub Son) 대한외과학회 1982 Annals of Surgical Treatment and Research(ASRT) Vol.24 No.11

腎性高血壓의 實驗的 模型에 있어 腎臟의 RENIN遊離의 特性

張一成,曺景宇 충남대학교 의과대학 지역사회의학연구소 1984 충남의대잡지 Vol.11 No.1

It has long been suggested that the change of renin-angiotensin system is responsible for increased arterial blood pressure in experimental hypertension. But the exact nature of the cause and maintenance of early and late phase of renal hypertension is still controversial. To clarify the nature of the renin release in both clipped and non-clipped kidney of two-kidney one-clip Goldblatt hypertensive model, in vitro slice experiments have been done in rats. Experiments were carried out in the rats of 3, 7, and 35 days of operation. Percent release of renin from the clipped kidney was suppressed compared to its corresponding sham-operated and control rats. Percent release of renin from the untouched non-clipped kidney 3 to 7 operation days of rats was much more suppressed than the clipped kidney. The responsiveness of the 3 and 7 days non-clipped kidney to the beta-receptor agonist, isoproterenol was accentuated by 290 and 210 percent respectively, while the increments of the clipped kidney were not different from its corresponding sham-operated and control rats. Renin suppression of clipped and non-clipped kidney by angiotensin II was attenuated compared to its control rats but was no differences between both kidneys of Goldblatt rats. These data suggest that the renin response to beta-receptor agonist, isoproterenol, has been accentuated in the non-clipped kidney by some changes in adrenergic beta-receptor or intracellular renin pools, and that the negative feedback control mechanism controlling renin-angiot system by angiotensin has been attenuated in two-kindey, one-clip Goldblatt hypertensive rats.

조기 위암의 임상적 고찰

장일성,김영일 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

This report is a clinical review of 50 cases of early gastric cancer that were treated and followed during 6 years from June. 1985 to June 1990. 1. The peak incidence age was 50 decade(38%), the mean age was 50 years, the ratio of male to female was 3:2. 2. The preoperative diagnostic rate was 52% by double conrast and 60% by endoscopy and biopsy. 3. The most common size of lesions was 1.1-2cm(32%) the smaller of lesion, the greater incidence of invasion rate to submucosa but no relation to lymph node matastasis rate. 4. The most common type of lesion was IIc(28%), the depressed type(III, IIb+c, IIc) was lymph node metastasis, but the elevated type and flat type was not lymph node matastasis. 5. The most common histological type was moderate differentiated and signet-ring cell types(32.5%) the most common type of metastatic rate was moderate differentiated type (30.7%), the badder of differentiated type, the greater incidence of metastatic rate to lymph node. 6. The common sites were lower third and lesser curvature(50%). The greater incidence of metastatic rate and invasion rate to submucosa the site of posterior wall was. 7. The rate of lymph node matastasis was 6.3% in mucosa, 26.4% in submucosa and 20% in total. 8. Follow up studies were possible in 45 cases, in these 1 case was died, 1 case was recurred but alive.