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      • 高 에너지 放射線으로 單一照射한 家兎小腸의 病理組織學的 變化

        崔日淳,薛惠榮,徐源赫 고려대학교 의과대학 1986 고려대 의대 잡지 Vol.23 No.1

        When super-voltage cobalt 60 gamma ray treat many kinds of intra-abdominal tumors the small intestine is exposed to unwanted radiation effect and excessive amount of radiation dose is harmful for the small intestine. Author attempted the experimental study to search for maximum tolerable radiation dose of small intsetine. The pathological changes of small intestine of the rabbits following 1,500 rads, 2,500 rads and 3,500 rads single exposure of Cobalt 60 gamma ray have obtained with 80 experimental rabbits. The doses of 1,500 rads, 2,500 rads and 3,500 rads single exposures were equivalent of biologic effects of 4,500 rads in 4.5 weeks, 7,000 rads in 7 weeks and 9,000 rads in 9 weeks each other. Following 1,500 rads single exposure rabbits were terminated in 2 , 4 , 8 weeks intervals, 2,500 rads single exposure rabbits were terminated in 1, 2, 4 weeks intervals and 3,500 rads single exposure rabbits were terminated at two weeks period. And the small intestines were fixed to Formalin Solution immediately after dissection. The pathological changes were as follows: 1. Following 1,500 rads single exposure, 10%(3/30 ) of rabbits were dead by radiation and the small intestinal mucosa showed the necrosis of 100% in weeks subgroup and the inflammation of 73% and regeneration of 63% in 2.4% and 8 weeks subgroups. 2. Following 2,500 rads single exposure,57% (17/30) of rabbits were dead and the small intestinal mucosa showed the necrosis of 87%, inflammation of 89% and regeneration of 53% in 1 week, 2 weeks and 4 weeks subgroups. 3. Following 3,500 racs single exposure, 93%(14/15) of rabbits were dead and the small intestine showed necrosis of 100% and inflammation of 47% in 2 weeks subgroup. 4. 4 rabbits showed the metaplastic changes on small intestine in 1,500 rads and 2,500 rads single exposure groups. In conclusion, over 1,500 rads single exposure by using high energy radiation caused severe radiation effects and metaplastic changes on small intestines of rabbits.

      • KCI등재

        전후위 뇌정맥상에서 시상선조체정맥이 내대뇌정맥과 형성하는 각에 관한 관찰

        최일순 대한영상의학회 1974 대한영상의학회지 Vol.10 No.1

        The size and shape of the lateral ventricle are frequently altered by intracranial lesions, and this may be reflected on cerebral angiogram. The size and dilatation of the lateral ventricle may be estimated by the course of the thalamostirate vein (TSV) and the distance between the midline and the TSV in frontal projection, the course of the pericallosal artery and the distance between the venous angle and subependymal veins in lateral projection. However, little description can be found in the literature about the method of expressing the size and degree of dilatation of the lateral ventricle on cerebral angiogram. The authors have attempted to find out an easy way of precisely estimating the size of the lateral ventricle and to observe ow it can be applied in the patients with various expanding intracranial lesions. We measured the angle formed between the internal cerebral vein(ICV) and the TSV in the anteroposterior roentgenograms of venous phase in normal group composed of 61 patients in whom no significant abnormality could be detected neurologically or by other methods, and in 18 patients with expanding intracranial lesions. The results obtained are as follows: 1. In the normal group, the average angle formed between the ICV and TSV on the anteroposterior angiogram obtained with the central beam projected making an angle of 10 to 15。 with the orbitomeatal line was 25.7$\pm$3.9。, ranging from 19 to 34$^{\circ}$. the angle measured from 20 to 30$^{\circ}$ in 85% of the normal group. There was no significant difference between the male and the females as well as between the children and adults. 2. The measurement of the angle was found to reflect faithfully the size of the lateral ventricle on the side examined, increasing as the lateral ventricle dilated. When the angle measures more than 33$^{\circ}$, the lateral ventricle would certainly be dilated. The lateral ventricle can be taken as moderately dilated when the measurement exceeds 40$^{\circ}$ and as severely dilated when the an le is over 50$^{\circ}$. On the contrary, it may be conceived that the lateral ventricle is compressed and deformed by an expanding lesion on the same side when the angle measures less than 20$^{\circ}$. 3. the measurement of the angle varied even in the same individual as the angle of central beam to the orbitomeatal line changed. It measured larger on the straight anteroposterior view and smaller on the half-aixal view. It is postulated that the normal value given above can only be applied when the anteroposterior roentgenogram is obtained in standard projection, in which the bifurcation of the internal carotid artery is usually thrown well above the orbit and the petrous bone. 4. The main axis of direction of the TSV was straight in normal group and deviated laterally describing downward and lateral convexity when the lateral ventricle was dilated.

      • KCI등재

        공복시 및 식후 $^{131}\textrm{I}$ 투여가 갑상선의 옥소섭취율에 미치는 영향에 관한 연구

        최일순 대한영상의학회 1976 대한영상의학회지 Vol.12 No.1

        The thyroid radioiodine uptake test, the most widely employed method of evaluating thyroid function, is usually performed as a rule by giving an oral dose of I in fasting state. Therefore, most of the out-patients have to visit the hospital in fasting state some other day for the uptake study, and it is frequently needed for the in-patient to stay in hospital one more day so as to get the examination done. For the purpose of reducing such an inconvenience for the patient, the authors have undertaken an observation to evaluate the validity of performing thyroid iodine uptake test in non-fasting condition. The thyroid uptake rates of I were measured in usual manner after giving an oral dose of 50$\mu$Ci of Na I to 8 healthy individuals in fasting and non-fasting states respectively, and 20-minute uptake curves were recorded at the body surface over the thyroid gland employing renogram apparatus. On the other hand, the plasma level of TSH was titrated by means of radioimmunoassay at fasting state in 22 healthy persons and shortly after meal in 17 individuals. The thyroid uptake of I was slightly but definitely greater when the examination was performed in non-fasting state than when it was done in fasting state. The mean values obtained in fasting condition were 6.1$\pm$4.1% at 1 hour, 11.5$\pm$6.0% at 2 hours, 15.3$\pm$6.3% at 6 hours and 22/9$\pm$5.8% at 24 hours. When the examination was carried out after meal, the mean values were 10.0$\pm$4.4.% at 1 hours, 15.5$\pm$4.9% at 2 hours, 22.8$\pm$4.2% at 6 hours and 30.4$\pm$7.8% at 24 hours. The early thyroid uptake curves revealed rapid rising figure several minutes after ingestion of raioiodine in non-fasting state, while in fasting state definite rising tendency was observed 10 minutes after administration of I. The mean values of TSH in the plasma were 1.75$\pm$0.64$\mu$U/ml. in fasting state and 0.70$\pm$0.13$\mu$U/ml. in non-fasting state. In conclusion, the thyroid radioiodine uptake test can be done in non-fasting state with little in erference in accuracy, so that inconvenience of performing the uptake study in fasting state may be avoided.

      • KCI등재

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