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Proteomic Profiling of Serum from Patients with Tuberculosis
송상훈,한민제,최양선,단기순,양만길,송정한,박성섭,이재호 대한진단검사의학회 2014 Annals of Laboratory Medicine Vol.34 No.5
Background: Effective treatment and monitoring of tuberculosis (TB) requires biomarkers that can be easily evaluated in blood samples. The aim of this study was to analyze the serum proteome of patients with TB and to identify protein biomarkers for TB. Methods: Serum samples from 26 TB patients and 31 controls were analyzed by using nano-flow ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry in data-independent mode, and protein and peptide amounts were calculated by using a label-free quantitative approach. The generated data were analyzed by using principal component analysis and partial least squares discriminant analysis, a multivariate statistical method. Results: Of more than 500 proteins identified, alpha-1-antitrypsin was the most discrimina- tive, which was 4.4 times higher in TB patients than in controls. Peptides from alpha-1-an- titrypsin and antithrombin III increased in TB patients and showed a high variable impor- tance in the projection scores and coefficient in partial least square discriminant analysis. Conclusions: Sera from patients with TB had higher alpha-1-antitrypsin levels than sera from control participants. Alpha-1-antitrypsin levels may aid in the diagnosis of TB.
TRIZ 기반 불량 주요 원인 선정을 통한 공정 최적화 방안
송상훈,박재현,송관배 대한안전경영과학회 2017 대한안전경영과학회 학술대회논문집 Vol.2017 No.04
The background of this study is to establish a systematic development process for SSD(Solid State Drive) which is being watched as the next generation auxiliary memory device and to make stable production. In order to do so, we select the two products that have been developed and classify and analyze all defects generated in each product by type and process of defects. The root cause of the fault and its background were reflected in the contradiction matrix of TRIZ's technical contradiction, and the improvements suggested in the 40 inventive principles were reflected in the test case design methodology of each process. Finally, this study suggests a process optimization method for systematic development.
송상훈 한국정보처리학회 2004 정보처리학회논문지. 컴퓨터 및 통신시스템 Vol.11 No.6
The provision of location tracking for mobile agents is designed to deliver a message to a moving object in a network. Most tracking methods exploit relay stations that hold location information to forward messages to a target mobile agent. In this paper, we propose an efficient location tracking method for mobile agents using the domain-based proxy as a relay station. Mobile agents can reduce the length of their migration paths by visiting hosts in the same domain first, rather than selecting hosts randomly. The proposed method exploits the domain-based moving patterns of mobile agents and minimizes registration and message delivery costs. Since the long proxy chain can contribute to the high message delivery cost, we also propose a compressing method to reduce the message delivery cost. 이동 에이전트에 대한 위치 추적 기능은 네트워크에서 움직이는 개체에 메시지를 전달하기 위한 것이다. 대부분의 위치 추적 방법들은 이동 에이전트의 현재 위치 정보를 가지고 있는 릴레이 노드를 사용하여 메시지를 전달할 수 있게 한다. 본 논문은 도메인 기반의 프록시를 이용한 효율적인 위치 추적 방법을 제안한다. 이동 에이전트들이 이동 할 호스트를 무작위로 결정하지 않고 같은 도메인에 있는 호스트들을 먼저 방문하는 특징을 이용하여 위치 정보 등록 비용과 메시지 전달 비용을 최소화 하는 것이다. 도메인 기반 프록시는 위치 정보 등록 비용을 줄이는데 효과적이지만, 프록시 체인의 길이가 길어지면 메시지 전달 비용을 높일 수 있는데 프록시 체인의 길이를 압축 시켜 메시지를 효율적으로 전달하는 방법을 제안한다.