半夏의 修治에 관한 文獻的 考察

孔福哲,高雲彩 대한본초학회 1996 大韓本草學會誌 Vol.11 No.1

The results of the study on the preparation of PHIZOMA PINELLIAE were as follows: 1. Preparations used in past were effective for reducing side effects of PHIZOMA PINELLIAE, and were safe in clinical application. 2. The aims of preparations of RHIZOMA PINELLIAE were safer application by reducing poisonous character of RHIZOMA PINELLIAE, and increase the range of clinical application by using kinds of herbs in procedure of preparation. 3. Modern researches say, raw RHIZOMA PINELLIAE has irritation and toxicity, but the toxicity can be reduced by roasting and broiling, and the irritation can be removed by boiling, so raw RHIZOMA PINELLIAE can be used in decocted medicinal herbs. 4. ALUMEN(白?) has the best effect of reducing toxicity of RHIZOMA PINELLIAE, and has the strongest reducing level of irritation and toxicity of RHIZOMA PINELLIAE, boiling and using RHIZOMA ZINGIBERIS(生薑) comes the next. 5. Using Heat and pressure and many other modern preparations can reduce the toxicity, the loss of availability and the time for preparation of RHIZOMA PINELLIAE. According to above results, combining methods of modern and the past used in preparation of RHIZOMA PINELLIAE can be more effective in clinical application and can prevent poisoning.

細辛에 관한 文獻的 考察

孔福哲,金瑩均 동의대학교 한의학연구소 1997 동의한의연구 Vol.1 No.-

ASARI HERBA CUM RADICE was classified first-class herb by Shinnongbonchokyung(神農本草經) which was written in Chin-Han dynasty(秦漢代). It has been widely used to many diseases connected with nose, lung and cold evils. It can be gathered in many countries in Korea and China, and due to the reason many forgeries were soiled by herb merchant to medical doctors. This study was done in order to assist doctors using ASARI HERBA CUM RADICE more accurately. In small dose ASARI HERBA CUM RADICE has no toxic effect, but if used in large amount of ASARI HERBA CUM RADICE, it can produce many toxic effects. And doctors in past knew it already, so they alarmed it. And in order to exhibit more effects of ASARI HERBA CUM RADICE, it must be used only with root. The origins, shapes and effects of ASARI HERBA CUM RADICE were briefed in many cases, but those were not enough for effective use, so furthur studies ye to be followed in future.

補骨脂 水針이 白鼠의 副腎皮質 機能不全에 미치는 影響

孔福哲,高雲彩 대한본초학회 1995 大韓本草學會誌 Vol.10 No.1

This study was carried out to investigate experimently the effect of aqua-acupuncture of Psoraleae Fructus in rats with acute adrenocortical insufficiency. The obtained results were as follows: 1. The levels of serum cortisol were remarkably increased comparing with those control group in case of sin-su group. 2. The concentrations of serum glucose were remarkably increased comparing with those control group in case of sin-su group. 3. The concentrations of serum total protein were remarkably decreased comparing with those control group in case of sin-su group. 4. The counts of blood eosinophils were remarkably decreased comparing with those control group in case of sin-su group. 5. The adrenal weight were significantly increased comparing with those control group in case of sin-su group.

細辛 根의 抗 알레르기 效果에 대한 實驗的 硏究

孔福哲,金塋均 대한한방성인병학회 1998 韓方成人病學會誌 Vol.4 No.1

This study was investigated the inhibitory activity of RADIX ASARI (RA) on type Ⅰ immediate hypersensitivity of the anaphylactic type. RA inhibited compound 48/80 -induced anaphylaxis 100% with a dose of 0.5g/㎏ body weight at 1 h before or 5 and 10 min after injection of compound 48/80. RA also exhibited the dose-dependent inhibitory effect on compound 48/80-induced, substance-p-induced and anti-DNP IgE-induced histamine release from rat peritoneal mast cells. Moreover, it was clearly demonstrated that RA and disodium cromoglycate disodium cromoglycate potently inhibited such type Ⅰ allergic reactions as anaphylactic shocks, suggesting that these drugs, at least in part, share the same mechanism of action. It is suggested that RA may exert a stronger inhibition on the mast cell degranulation process. When I examined the effect of RA on the release of IgE in the mouse spleen whole cells and human myeloma U266131, the release of IgE is inhibited by RA. Stimulation of RBL-2H_3 cells with anti-DNP IgE for 16hr induced the expression of TNF-α mRNA but RA decreased TNF-α mRNA expression. These results suggest the possibility that RA-induced inhibition of type Ⅰ allergic reaction is regulated by histamine, IgE and TNF-α.

滋陰八味煎이 卵巢摘出 白鼠의 骨多孔症에 미치는 影響

김덕님,공복철 대한한방부인과학회 2005 大韓韓方婦人科學會誌 Vol.18 No.2

Purpose : This study is to examine what are the effects of the Jaeumpalmijeon(JPJ) on the ovariectomized rat model of postmenopausal osteoporosis. Methods : 12weeks Female Sprague-Dawley 30 rats of weighting 250-300g, were divided into three groups including the sham operation groups(10heads) and overiectomy groups(10heads). then we observed changes in the body weight, serum metabolic products and femoral trabecular bone. Results : 1. Body weight in control group showed significant increase in comparison with sham, but that in JPJ-treated showed no change in comparison with control. 2. The level of serum albumin in control group showed significant decrease in comparison with sham. That in JPJ-treated was slightly decreased in comparison with control. 3. The level of serum ALP activity in control group showed significant increase in comparison with sham, but that in JPJ-treated was significantly decreased in comparison with control. 4. The level of serum AST in control group showed no change in comparison with sham, but that in JPJ-treated was significantly decreased in comparison with control. The level of serum ALT did not significant change among the three groups. 5. Trabecular bone area as well as trabecular thickness in control group showed significant decrease in comparison with sham. Those in JPJ-treated showed significant increase in comparison with control. 6. Trabecular separation in control group showed significant increase in comparison with sham. Those in JPJ-treated showed significant decrease in comparison with control. 7. Osteoclast number and oseoblast surface in control group showed significant increase in comparison with sham. Those in JPJ-treated showed significant decrease in comparison with control. Conclusion : JPJ has shown to be capable of preventing and curing osteoporosis caused by old-aged and postmenopause.

자궁경부암세포(子宮頸部癌細胞)(HeLa cell)에서 유향(乳香)의 세포고사(細胞枯死) 기전(機轉) 연구(硏究)

박경미 ( Kyung Mi Park ),공복철 ( Bok Cheul Kong ),이수정 ( Su Jung Lee ),최창민 ( Chang Min Choe ),유심근 ( Sim Keun Yoo ) 대한한방부인과학회 2006 大韓韓方婦人科學會誌 Vol.19 No.2

女高生 月經痛에 대한 酒煮當歸丸의 효능에 관한 임상적 연구

문덕빈,김미진,엄윤경,공복철,이인선 대한한방부인과학회 2005 大韓韓方婦人科學會誌 Vol.18 No.2

Purpose : This study is to identify the clinical effects of Jujadanggui-hwan in the treatment of dysmenorrhea with cold hypersensitivity. Methods : Jujadanggui-hwan were prescribed to 24 dysmenorrhea patients with cold hypersensitivity of hands and feet or with leucorrhea three times a day for 13 weeks. Results : After the treatment, numerical index for the pain was obviously reduced 'tot' point 2.12. It means that pain index as the patient can't do everyday occurrences reduce to 3 grad enough to do ordinary experience. Conclusion : Jujadanggui-hwan mentioned in Dongeuibogam has an effect on leucorrhea and cold hypersensitivity of hands and feet, lower abdomen and lumbus. So this study shows that Jujadanggui-hwan has remarkable effects on dysmenorrhea with cold hypersensitivity.

재발성 난소암 환자의 화학적 항암요법 후유증 치험 1례

백지원,남우진,김순아,공원호,박여빈,박윤령,공복철 대한한방부인과학회 2019 大韓韓方婦人科學會誌 Vol.32 No.2

Objectives: Most of the time after chemotherapy for ovarian cancer, the immune system is getting even worse with reduction of whole blood cell. The purpose of this study is to report the effect of korean medical treatment on Sequela including pancytopenia after chemotherapy for recurrent ovarian cancer after hysterectomy. Methods: The patient having treated with hospital management from June 8th in 2017 until July 5th in 2017, participated. Her chief complaints were fatigue, tinnitus, dizziness, decreased appetite due to glossodynia and constipation. We diagnosed her as pancytopenia based on her whole blood test result. We treated the patient with acupuncture, herbal medicine, cupping and moxibustion. The efficacy of treatment was evaluated with Numerical Rating Scale (NRS) and blood test. Results: During hospitalization period, the symptoms including fatigue, tinnitus, dizziness, decreased appetite, constipation and pancytopenia were reduced. After discharging, we identified that her blood levels are maintained and ovarian cancer no longer recurred. Conclusions: To recover from Sequela including pancytopenia following chemotherapy for recurrent ovarian cancer after hysterectomy, Korean medical treatment is considered to be effective.

삼릉(三稜)이 자궁경부암세포(子宮頸部癌細胞)(HeLa cell)의 Apoptosis에 미치는 영향(影響)

홍기철 ( Ki Cheul Hong ),김주연 ( Joo Yeon Kim ),공복철 ( Bok Cheul Kong ),최창민 ( Chang Min Choi ),유심근 ( Sim Keun Yoo ) 대한한방부인과학회 2005 大韓韓方婦人科學會誌 Vol.18 No.4

Purpose: This study is to examine the ability of Rhizoma Scirpi (RS) to induce HeLa cell viability. Methods: We culture HeLa cell which is human metrocarcinoma cell in D-MEM included 10% fetal bovine serum(Hyclone Laboratories) below 37℃, 5% CO2. Then we observed apoptosis of log phage cell which is changed cultivation liquid 24 Hours periodically. Results: 1. RS induces mitochondria membrane potential collapse. 2. P38 MAPK is involved in RS-induced death in HeLa cells. 3. P38 MAPK is involved in RS-induced apoptosis in HeLa cells. 4. P38 MAPK reguates RS-induced caspase-3, -8 and -9 activation in HeLa cells. 5. The inhibition of caspase regulates RS-induced cell death in HeLa cells. 6. RS induces mitochondria membrane potential collapse in HeLa cells. 7. P38 MAPK is involved in the regulation of Bcl-2 and Bax in HeLa cells. 8. RS regulates the expression of Bcl-2 and Bax in HeLa cells. 9. SR induces p38 MAPK activation in HeLa cells. Conclusion: RS induces apoptosis in HeLa cells via p38 MAPK activation.

유두상 갑상선암 환자의 갑상선절제술 후 합병증에 대한 임상경과 보고 3례

박은영 ( Eun Young Park ),권형근 ( Hyoung Geun Gwen ),공복철 ( Bok Chul Kong ),김동철 ( Dong Chul Kim ) 대한한방부인과학회 2013 大韓韓方婦人科學會誌 Vol.26 No.3

Objectives: Thyroid cancer is the most common cancer for female in Korea. This study aims to report the effects of Korean medicine on complications after total thyroidectomy and neck dissection in the papillary thyroid carcinoma. Methods: The 3 patients with papillary thyroid carcinoma were treated by Korean medicine such as acupuncture, moxibustion and pharmacopuncture therapy. We evaluated the results of treatments by change of symptoms. Results: After treatments such as acupuncture, moxibustion and pharmacopuncture therapy except herb medicine, the symptoms of complications after total thyroidectomy and neck dissection were improved. Conclusions: This study shows that Korean medicine has effects on complications after total thyroidectomy and neck dissection in the papillary thyroid carcinoma.