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오명호,이동환,이상주,강형채 순천향대학교 1986 논문집 Vol.9 No.2
The isoniazid is the principal therapeutic regimen in the tuberculosis and is used popularly among the Korean. It is metabolized via acetylation, so human being is classified into two groups: slow acetylator and fast acetylator. The Korean is being to rapid acetylator. So, this study was performed to prove that giving a half-dose twice is better than a single dose. The authors observed serum INH concentration in 10 cases of the healthy Koreans. In group I, INH 400mg was given at 8AM, and in group II, INH 200mg was given respectively at 8AM & 8PM for 7 days. After then, blood sampling was done at 10AM and 10PM in both groups. The levels of serum INH were measured quantitatively by spectrophotometry equipped with a microcell unit. The results obtained were as follows: 1) The mean INH concentration in group I 10AM was 3.34±1.70mg/ml. 2) The mean INH concentration in group I 10PM was 0.26±0.35mg/ml. 3) The mean INH concentration in group II 10AM was 1.38±0.88mg/ml. 4) The mean INH concentration in group II 10PM was 1.63±0.53mg/ml. So, the authors concluded that giving a half-dose twice is bettwe than a single dose.
소아에 있어서 B형 간염 백신 접종후 HBs항체 상승율에 관하여
姜炯埰,李尙柱 순천향대학교 1987 논문집 Vol.10 No.2
And epidemiologic study on responses of HBsAb after vaccination of Hepavax-B(manufactured by Green Cross Corporation, Korea) in Korean children was carried out in order to investigate the response of hepatitis B vaccine and provide the appropriate recommendations for hepatitis B vaccination. We conducted HBsAg, HBsAb and HBcAb determinations by the method of radioimmunoassay on 143 healthy children who visited for the purpose of immunization with HB vaccine and conducted HBsAg, HBsAb and HBcAb determinations after 2nd injection and 3rd injection on 123 children except 20 children who were positive for HBsAb. A serum sample was considered positive for HBsAb if the ratio of the sample counts per minute to the negative control serum counts per minute was 3 or greater. The results obtained were as follows : 1) There were no sex differences (60.8% in males, 39.2% in females). Age distribution was as follows : 16.8% under lyr of age, 44.0% between the ages of 1-5yr, 27.3% between the ages of 6-11yr, 11.9% between the ages of 12-15yr. 2) Among the 143 children, 14.0% were positive for HBsAb, and all of the children were negative for HBsAg and HBsAb. 3) Among the 143 children, 20(14.0%) were positive for HBsAb before vaccination(20.8k% under lyr of age, 11.1% between the ages of 1-5yr,7.7% between the ages of 6-11yr, 29.4% between the ages of 12-15yr). 4) Among the 123 children, 95 were positive for HBsAb. The response rate for HBsAb after 2nd injection was 50.5% but the response rate was markedly increaed to 84.5% after 3rd injection. Ratio units were also higher after 3rd injection than 2nd injection. More than 50 R.U. which were considered as a relatively high unit were 8.6% after 2nd injection but 35.1% after 3rd injection. 5) None of the vacciness wee positive for HBsAg and HBcAb and developed any of the side reactions. These results suggested that : a) early immunization with HB vaccine is imperative due to high prevalenc rate in Korea and progression to chronic hepatitis, cirrhosis and hepatocellular carcinoma in chronic carrier, b) 3 injections are recommended to achieve higher HBsAb responses and titers, c) for a nation-wide vaccination, it is essential to develop a cheap, safe and efficacious vaccine, d) to establish th most reasonable vaccination schedule in pediatric age, it is essential to study the appropriate dose, route of injection, interval and frequency of injection on the base of policy in all of th general hospitals.