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TOSS: Telecom Operations Support Systems for Broadband Services
Chen, Yuan-Kai,Hsu, Chang-Ping,Hu, Chung-Hua,Lin, Rong-Syh,Lin, Yi-Bing,Lyu, Jian-Zhi,Wu, Wudy,Young, Hey-Chyi Korea Information Processing Society 2010 Journal of information processing systems Vol.6 No.1
Due to the convergence of voice, data, and video, today's telecom operators are facing the complexity of service and network management to offer differentiated value-added services that meet customer expectations. Without the operations support of well-developed Business Support System/Operations Support System (BSS/OSS), it is difficult to timely and effectively provide competitive services upon customer request. In this paper, a suite of NGOSS-based Telecom OSS (TOSS) is developed for the support of fulfillment and assurance operations of telecom services and IT services. Four OSS groups, TOSS-P (intelligent service provisioning), TOSS-N (integrated large-scale network management), TOSS-T (trouble handling and resolution), and TOSS-Q (end-to-end service quality management), are organized and integrated following the standard telecom operation processes (i.e., eTOM). We use IPTV and IP-VPN operation scenarios to show how these OSS groups co-work to support daily business operations with the benefits of cost reduction and revenue acceleration.
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A Design Approach for the Interior Anchorage Zone of Post-tensioned Concrete Structure
Jian-Li Zhao,Shui-Long Shen,Lin-Bing Wang,Jun Chen 대한토목학회 2011 KSCE Journal of Civil Engineering Vol.15 No.3
For the interior anchorage zone in post-tensioned concrete structure, International Federation for Presterssing (FIP) proposed a design method based on the theory of Strut-and-Tie Model (STM) (called FIP-STM in the following context). However, the condition of FIP-STM is that the dimension ratio of anchor, b/h, is equal to 1/9. In this paper, the stress distribution in interior anchorage zone was analyzed via using Finite Element Method (FEM) at first. The relationship between ratio of internal force over post-tensioned load (F/P) and dimension ratio (b/h) (F/P-b/h curve) was obtained. FEM results show that in case of b/h<1/9, the interior anchorage zone can be simplified to the core region, in which b/h is equal to 1/9 and FIP-STM is still applicable. However, in case of b/h>1/9, the amount of non-prestressed rebar designed in interior anchorage zone by use of FIP-STM is more than that required, and in some cases it is difficult to allocate non-prestressed rebar in the crowded space. Based on the results of stress analysis, a modified approach for FIP-STM was presented, which can be applied for any dimension ratio. With the proposed modification on FIP-STM, the non-prestressed rebar can be reasonably allocated in the narrow space of interior anchorage zone via modifying the internal forces and geometry of FIP-STM. The analytical result shows that for interior anchorage zone about 30% of non-prestressed rebar can be reduced via using the proposed method compared with that using FIP-STM if b/h is equal to 3/10.
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Bing Xia,Jian Shang,Xiaobing Wang,Wei Wang,Huaqin Pan,Shi Liu,Lixia Li,Liping Chen 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.1
Purpose: The -1237T/C polymorphism of the Toll-like receptor 9 (TLR9) gene has been implicated in the susceptibility of inflammatorybowel diseases (IBDs), but the results remain conflicting. We further investigated this association via meta-analysis. Materials and Methods: Multiple electronic databases were extensively searched until February, 2015. The strength of associationwas evaluated by calculating the pooled odds ratios (ORs) and 95% confidence intervals (CIs). Results: A total of 2987 cases and 2388 controls from eight studies were analyzed. Overall, association was found between TLR9 -1237T/C polymorphism and the risk of IBDs when all the studies were pooled (recessive model, OR: 1.59, 95% CI: 1.02–2.47, p=0.04; homozygote comparison, OR: 1.62, 95% CI: 1.04–2.52, p=0.03; allele model, OR: 1.13, 95% CI: 1.00–1.27, p=0.05). Stratificationby ethnicity indicated an association between TLR9 -1237T/C polymorphism and IBDs risk in Caucasians (recessive model,OR: 1.59, 95% CI: 1.02–2.47, p=0.04; homozygote comparison, OR: 1.62, 95% CI: 1.04–2.52, p=0.03; allele model, OR: 1.12, 95% CI: 1.00–1.27, p=0.05). When stratified by disease type, significant correlation were only found in the Crohn’s disease subgroup (recessive model, OR: 1.69, 95% CI: 1.05–2.73, p=0.03; homozygote model, OR: 1.74, 95% CI: 1.07–2.82, p=0.02; allele model, OR: 1.15, 95% CI: 1.01–1.32, p=0.04). Conclusion: The present study suggested that the TLR9 -1237T/C polymorphism might act as a risk factor in the development of IBDs, particularly in Caucasians.
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Chen, Ya-bing,Fu, Mei,Lan, Dao-liang,Li, Jian Asian Australasian Association of Animal Productio 2015 Animal Bioscience Vol.28 No.1
Insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-1 (IGFBP-1) play a pivotal role in regulating cellular hypoxic response. In this study, we cloned and characterized the genes encoding IGF-1 and IGFBP-1 to improve the current knowledge on their roles in highland Bos grunniens (Yak). We also compared their expression levels in the liver and kidney tissues between yaks and lowland cattle. We obtained full-length 465 bp IGF-1 and 792 bp IGFBP-1, encoding 154 amino acids (AA) IGF-1, and 263 AA IGFBP-1 protein, respectively using reverse transcriptase-polyerase chain reaction (RT-PCR) technology. Analysis of their corresponding amino acid sequences showed a high identity between B. grunniens and lowland mammals. Moreover, the two genes were proved to be widely distributed in the examined tissues through expression pattern analysis. Real-time PCR results revealed that IGF-1 expression was higher in the liver and kidney tissues in B. grunniens than in Bos taurus (p<0.05). The IGFBP-1 gene was expressed at a higher level in the liver (p<0.05) of B. taurus than B. grunniens, but it has a similar expression level in the kidneys of the two species. These results indicated that upregulated IGF-1 and downregulated IGFBP-1 are associated with hypoxia adaptive response in B. grunniens.
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Streptomyces lushanensis sp. nov., a novel actinomycete with anti-cyanobacterial activity
Zhang, Bing-Huo,Cheng, Juan,Chen, Wei,Li, Han-Quan,Yang, Jian-Yuan,Park, Dong-Jin,Kim, Chang-Jin,Shen, Rui,Duan, Yan-Qin,Li, Wen-Jun Nature Publishing Group 2015 The Journal of Antibiotics Vol. No.
<P>Strain JXJ 0135(T), an anti-cyanobacterial actinomycete, was isolated from a soil sample collected from Lushan Mountain, south China, and identified by using polyphasic approach. Phylogenetic analysis of the near-complete 16S rRNA gene sequence indicated that strain JXJ 0135(T) belongs to the genus Streptomyces and exhibited distinct subclade and also highest similarity (98.6%) to Streptomyces scopuliridis RB72(T). The strain developed well-branched substrate and aerial mycelia, and produced spiral spore chains. Spores were elliptical and the spore surface was smooth. The strain contained LL-diaminopimelic acid with whole-cell sugars of mannose, rhamnose, glucose and galactose. Phospholipids were diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylinositol mannosides, phosphotidylinositol dimannoside, an unidentified aminophospholipid and an unknown phospholipid. The menaquinones were MK-9(H6) and MK-9(H8). The major components of the fatty acids were anteiso-C15:0, iso-C16:0, anteiso-C17:0, iso-C15:0, C16:0, iso-C17:0 and iso-C14:0. The G+C content was 69.3?mol%. The DNA-DNA hybridization value between JXJ 0135(T) and S. scopuliridis RB72(T) was 41.21.4%. On the basis of the polyphasic data, strain JXJ 0135(T) represents a novel species of the genus Streptomyces, for which the name Streptomyces lushanensis sp. nov. is proposed. The type strain is JXJ 0135(T) (=DSM 42121(T)=JCM 19628(T)=KCTC 29261(T)=KACC 17834(T)=NRRL B-24994(T)).</P>
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Ya-bing Chen,Mei Fu,Dao-liang Lan,Jian Li 아세아·태평양축산학회 2015 Animal Bioscience Vol.28 No.1
Insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-1 (IGFBP-1) play a pivotal role in regulating cellular hypoxic response. In this study, we cloned and characterized the genes encoding IGF-1 and IGFBP-1 to improve the current knowledge on their roles in highland Bos grunniens (Yak). We also compared their expression levels in the liver and kidney tissues between yaks and lowland cattle. We obtained full-length 465 bp IGF-1 and 792 bp IGFBP-1, encoding 154 amino acids (AA) IGF-1, and 263 AA IGFBP-1 protein, respectively using reverse transcriptase-polyerase chain reaction (RT-PCR) technology. Analysis of their corresponding amino acid sequences showed a high identity between B. grunniens and lowland mammals. Moreover, the two genes were proved to be widely distributed in the examined tissues through expression pattern analysis. Real-time PCR results revealed that IGF-1 expression was higher in the liver and kidney tissues in B. grunniens than in Bos taurus (p<0.05). The IGFBP-1 gene was expressed at a higher level in the liver (p<0.05) of B. taurus than B. grunniens, but it has a similar expression level in the kidneys of the two species. These results indicated that upregulated IGF-1 and downregulated IGFBP-1 are associated with hypoxia adaptive response in B. grunniens.
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A rapid modeling method and accuracy criteria for common-cause failures in Risk Monitor PSA model
Zhang, Bing,Chen, Shanqi,Lin, Zhixian,Wang, Shaoxuan,Wang, Zhen,Ge, Daochuan,Guo, Dingqing,Lin, Jian,Wang, Fang,Wang, Jin Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.1
In the development of a Risk Monitor probabilistic safety assessment (PSA) model from the basic PSA model of a nuclear power plant, the modeling of common-cause failure (CCF) is very important. At present, some approximate modeling methods are widely used, but there lacks criterion of modeling accuracy and error analysis. In this paper, aiming at ensuring the accuracy of risk assessment and minimizing the Risk Monitor PSA models size, we present three basic issues of CCF model resulted from the changes of a nuclear power plant configuration, put forward corresponding modeling methods, and derive accuracy criteria of CCF modeling based on minimum cut sets and risk indicators according to the requirements of risk monitoring. Finally, a nuclear power plant Risk Monitor PSA model is taken as an example to demonstrate the effectiveness of the proposed modeling method and accuracy criteria, and the application scope of the idea of this paper is also discussed.
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Yun-Ru Chen,Ruo-Tong Zhao,Yi-Fang Xu,Yin-Jie Ma,Shao-Bo Hu,Xue-Hui Wang,Bing-Bing Fan,Yan-Ji Zhou,Yu-Bei Huang,Nicola Robinson,Jian-ping Liu,Zhao-Lan Liu 한국한의학연구원 2023 Integrative Medicine Research Vol.12 No.4
Background: Advanced pancreatic cancer (APC) is a fatal disease with limited treatment options. This study aims to evaluate the effectiveness and safety of different Chinese herbal injections (CHIs) as adjuvants for radiotherapy (RT) in APC and compare their treatment potentials using network meta-analysis. Methods: We systematically searched three English and four Chinese databases for randomized controlled trials (RCTs) from inception to July 25, 2023. The primary outcome was the objective response rate (ORR). Secondary outcomes included Karnofsky performance status (KPS) score, overall survival (OS), and adverse events (AEs). The treatment potentials of different CHIs were ranked using the surface under the cumulative ranking curve (SUCRA). The Cochrane RoB 2 tool and CINeMA were used for quality assessment and evidence grading. Results: Eighteen RCTs involving 1199 patients were included. Five CHIs were evaluated. Compound Kushen injection (CKI) combined with RT significantly improved ORR compared to RT alone (RR 1.49, 95 % CrI 1.21–1.86). Kanglaite (KLT) plus RT (RR 1.58, 95 % CrI 1.20–2.16) and CKI plus RT (RR 1.49, 95 % CrI 1.16–1.95) were associated with improved KPS score compared to radiation monotherapy, with KLT+RT being the highest rank (SUCRA 72.28 %). Regarding AEs, CKI plus RT was the most favorable in reducing the incidence of leukopenia (SUCRA 90.37 %) and nausea/vomiting (SUCRA 85.79 %). Conclusions: CKI may be the optimal choice of CHIs to combine with RT for APC as it may improve clinical response, quality of life, and reduce AEs. High-quality trials are necessary to establish a robust body of evidence. Protocol registration: PROSPERO, CRD42023396828.
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Qin, Yi,Chen, Jing,Li, Li,Liao, Chun-Jie,Liang, Yu-Bing,Guan, En-Jian,Xie, Yu-Bo Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4
Morphine is not only an analgesic treating pain for patients with cancer but also a potential anticancer drug inhibiting tumor growth and proliferation. To gain better insight into the involvement of morphine in the biological characteristics of gastric cancer, we investigated effects on progression of gastric carcinoma cells and the expression of some apoptosis-related genes including caspase-9, caspase-3, survivin and NF-${\kappa}B$ using the MGC-803 human gastric cancer cell line. The viability of cells was assessed by MTT assay, proliferation by colony formation assay, cell cycle progression and apoptosis by flow cytometry and ultrastructural alteration by transmission electron microscopy. The influences of morphine on caspase-9, caspase-3, survivin and NF-${\kappa}B$ were evaluated by semi-quantitative RT-PCR and Western blot. Our data showed that morphine could significantly inhibit cell growth and proliferation and cause cell cycle arrest in the G2/M phase. MGC-803 cells which were incubated with morphine also had a higher apoptotic rate than control cells. Morphine also led to morphological changes of gastric cancer cells. The mechanism of morphine inhibiting gastric cancer progression in vitro might be associated with activation of caspase-9 and caspase-3 and inhibition of survivin and NF-${\kappa}B$.
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