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Xu Xu,Jinhong Yu,Zihai He,Shaorong Lu,Dong Guo 한국고분자학회 2014 Macromolecular Research Vol.22 No.10
A reactive compatibilizer containing flexible segment (RCFS) was synthesized and characterized by Fouriertransform infrared spectroscopy (FTIR) and gel permeation chromatography (GPC). The RCFS was used as acompatibilizer for the preparation of lignin/polypropylene (PP) wood plastic composites, and the effect of the RCFSon the properties of composites (e.g., mechanical properties, thermal properties, crystal structure, and morphology)were investigated in detail. Experimental results indicated that the lignin/PP composite displayed the best performancewith the addition of 2 wt% RCFS. Its impact strength, flexural strength, and modulus were 56.8%, 37.3%,and 20.6%, respectively, which are higher than those of the untreated composites. Moreover, RCFS treatment couldalso increase the thermal stability, crystallization rate, and degree of crystallinity of lignin/PP composites.
Finite Element Analysis and Optimization of Dither Mechanism in Dithered Ring Laser Gyroscope
Xu-dong Yu,Guo Wei,Xing-wu Long,Jian-xun Tang 한국정밀공학회 2013 International Journal of Precision Engineering and Vol. No.
This paper presents an optimal structural design of dither mechanism in dithered ring laser gyroscope (DRLG) using finite element analysis (FEA). We establish an approximate theoretical model of the dithering mechanism to calculate resonant frequency and adopt the modal analysis and dynamics analysis to search the optimal solution. The validity and efficiency of the FEA are conformed by comparing with the sinusoidal and random vibration experimental results. An optimal dither mechanism is fabricated and measured experimentally. The results demonstrate the good vibration-isolated performance for the optimal design.
The treatment effect of novel hGHRH homodimer to male infertility hamster
Xu-Dong Zhang,Xiao-Yuan Guo,Jing-Xuan Tang,Lin-Na Yue,Juan-Hui Zhang,Tao Liu,Yu-Xia Dong,Song-Shan Tang 대한생리학회-대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.6
Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important role in reproduction. To study the treatment effect of Grin (a novel hGHRH homodimer), the infertility models of 85 male Chinese hamsters were established by intraperitoneally injecting 20 mg/kg of cyclophosphamide once in a week for 5 weeks and the treatment with Grin or human menopausal gonadotropin (hMG) as positive control was evaluated by performing a 3-week mating experiment. 2-8 mg/kg of Grin and 200 U/kg of hMG showed similar effect and different pathological characteristics. Compared to the single cyclophosphamide group (0%), the pregnancy rates (H-, M-, L-Grin 26.7, 30.8, 31.3%, and hMG 31.3%) showed significant difference, but there was no difference between the hMG and Grin groups. The single cyclophosphamide group presented loose tubules with pathologic vacuoles and significant TUNEL positive cells. Grin induced less weight of body or testis, compactly aligned tubules with little intra-lumens, whereas hMG caused more weight of body or testis, enlarging tubules with annular clearance. Grin presented a dose-dependent manner or cell differentiation-dependentincrease in testicular GHRH receptor, and did not impact the levels of blood and testicular GH, testosterone. Grin promotes fertility by proliferating and differentiating primitive cells through up-regulating testicular GHRH receptor without triggering GH secretion, which might solve the etiology of oligoasthenozoospermia.
Yuan-Dong Xu,Ling-Ling Xie,Yu-Jun Zhang,Xiao-Yu Cao 대한금속·재료학회 2013 ELECTRONIC MATERIALS LETTERS Vol.9 No.5
Hexagonal molybdenum trioxide (h-MoO3) nanoparticles with a particle size of several tens of nanometers were prepared from sodium molybdate (Na2MoO4) using hydrothermal synthesis and ultrasonication. The morphology, structure, composition, and chemical states of the nanoparticles were characterized by x-ray diffraction,field-emission scanning electron microscopy, and Fourier transform-infrared spectroscopy. Cyclic voltammetry results showed a strong reduction peak, which indicated a lithium ion insertion/extraction mechanism. The plateau observed in the first discharge curve around 1.8 V was in accordance with the above mechanism,which was also verified by differential capacity measurements. Cycling performance results showed that the capacity retention was up to 90% in the second cycle and that the irreversible capacities decreased with subsequent cycles.
The treatment effect of novel hGHRH homodimer to male infertility hamster
Zhang, Xu-Dong,Guo, Xiao-Yuan,Tang, Jing-Xuan,Yue, Lin-Na,Zhang, Juan-Hui,Liu, Tao,Dong, Yu-Xia,Tang, Song-Shan The Korean Society of Pharmacology 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.6
Extra-hypothalamic growth hormone-releasing hormone (GHRH) plays an important role in reproduction. To study the treatment effect of Grin (a novel hGHRH homodimer), the infertility models of 85 male Chinese hamsters were established by intraperitoneally injecting 20 mg/kg of cyclophosphamide once in a week for 5 weeks and the treatment with Grin or human menopausal gonadotropin (hMG) as positive control was evaluated by performing a 3-week mating experiment. 2-8 mg/kg of Grin and 200 U/kg of hMG showed similar effect and different pathological characteristics. Compared to the single cyclophosphamide group (0%), the pregnancy rates (H-, M-, L-Grin 26.7, 30.8, 31.3%, and hMG 31.3%) showed significant difference, but there was no difference between the hMG and Grin groups. The single cyclophosphamide group presented loose tubules with pathologic vacuoles and significant TUNEL positive cells. Grin induced less weight of body or testis, compactly aligned tubules with little intra-lumens, whereas hMG caused more weight of body or testis, enlarging tubules with annular clearance. Grin presented a dose-dependent manner or cell differentiation-dependentincrease in testicular GHRH receptor, and did not impact the levels of blood and testicular GH, testosterone. Grin promotes fertility by proliferating and differentiating primitive cells through up-regulating testicular GHRH receptor without triggering GH secretion, which might solve the etiology of oligoasthenozoospermia.
Hai-Xia Li,Yan Ma,Yu-Xiao Yan,Xin-Ke Zhai,Meng-Yu Xin,Tian Wang,Dong-Cao Xu,Yu-Tong Song,Chun-Dong Song,Cheng-Xue Pan 고려인삼학회 2023 Journal of Ginseng Research Vol.47 No.6
Background: Caveolin-1, the scaffolding protein of cholesterol-rich invaginations, plays an important rolein store-operated Ca2þ influx and its phosphorylation at Tyr14 (p-caveolin-1) is vital to mobilize protectionagainst myocardial ischemia (MI) injury. SOCE, comprising STIM1, ORAI1 and TRPC1, contributesto intracellular Ca2þ ([Ca2þ]i) accumulation in cardiomyocytes. The purified extract of steamed Panaxginseng (EPG) attenuated [Ca2þ]i overload against MI injury. Thus, the aim of this study was to investigatethe possibility of EPG affecting p-caveolin-1 to further mediate SOCE/[Ca2þ]i against MI injury in neonatalrat cardiomyocytes and a rat model. Methods: PP2, an inhibitor of p-caveolin-1, was used. Cell viability, [Ca2þ]i concentration were analyzedin cardiomyocytes. In rats, myocardial infarct size, pathological damages, apoptosis and cardiac fibrosiswere evaluated, p-caveolin-1 and STIM1 were detected by immunofluorescence, and the levels ofcaveolin-1, STIM1, ORAI1 and TRPC1 were determined by RT-PCR and Western blot. And, release of LDH,cTnI and BNP was measured. Results: EPG, ginsenosides accounting for 57.96%, suppressed release of LDH, cTnI and BNP, and protectedcardiomyocytes by inhibiting Ca2þ influx. And, EPG significantly relieved myocardial infarct size, cardiacapoptosis, fibrosis, and ultrastructure abnormality. Moreover, EPG negatively regulated SOCE viaincreasing p-caveolin-1 protein, decreasing ORAI1 mRNA and protein levels of ORAI1, TRPC1 and STIM1. More importantly, inhibition of the p-caveolin-1 significantly suppressed all of the above cardioprotectionof EPG. Conclusions: Caveolin-1 phosphorylation is involved in the protective effects of EPG against MI injury viaincreasing p-caveolin-1 to negatively regulate SOCE/[Ca2þ]i.
Yu Zhao,Nana Li,Bin Xu,Bingzhi Dong,Shengji Xia 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.39 No.-
Hybrid poly(vinylidene fluoride) (PVDF) embedded with Zn–Al layered double hydroxides (LDH)membranes were fabricated via phase inversion. The physical and chemical properties of the novelpolymer membranes were characterized using different characterizations. Filtration and antifoulingexperiments were performed to examine the water permeability, rejection and antifouling ability of theprepared membranes. Results showed that membrane morphology was greatly changed due to theaddition of LDH and that the hybrid membrane exhibited greatly improved surface hydrophilicity, waterpermeability and antifouling property, with contact angle decreased from 76.58 to 69.08 and pure water(PW) flux increased from 8.01 L/m2 h bar to 48.95 L/m2 h bar.
Analysis of corrugated steel web beam bridges using spatial grid modelling
Dong Xu,Yingsheng Ni,Yu Zhao 국제구조공학회 2015 Steel and Composite Structures, An International J Vol.18 No.4
Up to now, Japan has more than 200 corrugated steel web composite beam bridges which are under construction and have been constructed, and China has more than 30 corrugated steel web composite beam bridges. The bridge type includes the simply supported beam, continuous beam, continuous rigid frame and cable stayed bridge etc. The section form has developed to the single box and multi-cell box girder from the original single box and single chamber. From the stress performance and cost saving, the span range of 50~150 m is the most competitive. At present, the design mostly adopts the computational analytical method combining the spatial bar system model, plane beam grillage model and solid model. However, the spatial bar system model is short of the refinement analysis on the space effect, such as the shear lag effect, effective distribution width problem, and eccentric load factor problem etc. Due to the similarity of the plane beam grillage method in the equivalence principle, it cannot accurately reflect the shearing stress distribution and local stress of the top and bottom plates of the box type composite beam. The solid model is very difficult to combine with the overall calculation. Moreover, the spatial grid model can achieve the refinement analysis, with the integrity of the analysis and the comprehensiveness of the stress checking calculation, and can make up the deficiency of the analytical method currently. Through the example verification of the solid model and spatial grid model, it can be seen that the calculation results for the stress and the displacement of two models are almost consistent, indicating the applicability and precision of the spatial grid model.
Effect of Portal Vein Chemotherapy on Liver Metastasis after Surgical Resection of Colorectal Cancer
Yu, Dong-Sheng,Li, Ying,Huang, Xin-En,Lu, Yan-Yan,Wu, Xue-Yan,Liu, Jin,Cao, Jie,Xu, Xia,Xiang, Jin,Wang, Guo-Ping Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9
Objective: To explore the effect of portal vein chemotherapy on liver metastasis after surgical resection of colorectal cancer. Methods: Patients fulfilling the eligibility criteria were assigned to receive either surgery plus 1-week continuous infusion of 5-FU (study group) or surgery alone (observational group). Patients in the study group received portal vein chemotherapy, whereby 5-FU (1000 mg/d) and heparin (5000 IU/d) infusion was initiated from the day of surgery and lasted for 7 consecutive days. Liver metastasis was monitored during five years follow-up postoperatively. Results: Sixty four patients were recruited and assigned to the study group (12 with colon and 20 with rectal cancer) or the control group (10 with colon and 22 with rectal cancer). Liver metastasis rate was 12.5% in study and 25.0% in observational group, the difference being significant (P<0.01). Conclusion: Portal vein chemotherapy could be an effective treatment in preventing liver metastasis after surgical resection of colorectal cancer.