Traumatic Abdominal Wall Hernia: A Case Report

( Youngro Yang ),( Kwangsig Kim ) 대한외상학회 2017 大韓外傷學會誌 Vol.30 No.2

Traumatic abdominal wall hernia is a rare condition that can follow any blunt trauma to the abdomen. Generally there has been an increase in the incidence of blunt abdominal trauma, although the case of traumatic abdominal wall hernias are rare. Probably due to the elasticity of the abdominal wall for resisting the shear forces generated by a traumatic impacts. In this case, we are reporting 1 rare case, diagnosed as an abdominal wall hernia associated with herniation of bowel loops due to blunt trauma without intra-abdominal injury including peritoneum. [ J Trauma Inj 2017; 30: 70-73 ]

Position recognition and user Identification system using Received Signal Strength Indicator (RSSI) in home healthcare based on Wireless Sensor Network (WSN)

양용주(Yongju Yang),윤영로(Youngro Yoon) 대한전자공학회 2006 대한전자공학회 학술대회 Vol.2006 No.11

Ubiquitous Location Based Services (u-LBS) will soon be able to issue very important services. They can define that recognizing object position at anytime, anywhere. At present, many researchers are making a brisk study of the position recognition and tracking. This paper is position recognition monitoring and user identification system. Position recognition monitoring is based on Local Based Services (LBS). User identification system automatically controls instruments which is located in home and freely measures body signal. We experiment at Home Health Management trial laboratory in YONSEI University. We implemented multi-hop routing methods using the Star-Mesh networks. Also, we use the sensor devices which are satisfied with the IEEE 802.15.4 standard requirements. Used devices are Nano-24 modules in Octacomm Co. Received Signal Strength Indicator (RSSI) is very important factor in position recognition analysis. it makes use of the way that decides position recognition and user identification in narrow indoor space. In experiments, we can analyze properties of the RSSI and draw the parameter about position recognition. Experimental results are that RSSI value is attenuated according to increasing distances and it can derive properties of the Radio Frequency (RF) signals. Moreover, we express monitoring program using Microsoft C#. Finally, the proposed methods are expected to protect sudden death and accident in home.

소장천공을 동반한 외상환자에서 단일공을 통한 진단적 복강경 후 최소절개를 통한 체외 소장복구: 증례 보고

양영로,김광식,Yang, Youngro,Kim, Kwang Sig 제주대학교 의과학연구소 2019 The Journal of Medicine and Life Science Vol.16 No.1

In a patient with blunt abdominal trauma with small bowel injury, early diagnosis is clinically challenging due to unclear clinical symptoms and signs in the early stage of an injury. On the other hand, a delay of diagnosis of bowel disruption may lead to increased complication and mortality. The diagnostic laparoscopy is very useful for the evaluation of the small bowel injury. Laparoscopy can reduce unnecessary open surgery in a patient with blunt abdominal trauma with subtle symptoms and imprecise findings on abdominal computed tomography. Also it can prevent delay of treatment and be converted immediately to open surgery as soon as bowel damage is revealed. Furthermore, extracorporeal repair of small bowel via mini-laparotomy after a single incision diagnostic laparoscopy in a patient with traumatic small bowel perforation was a feasible and safe alternative to conventional laparoscopy. We are pleased to introduce successfully treated cases by extracorporeal repair of small bowel via mini-laparotomy after a single incision diagnostic laparoscopy in a patient with small bowel perforation after blunt trauma.

A Case of Metastatic Renal Cell Carcinoma to Thyroid Gland

Jae-Geun Lee,Youngro Yang,Kwangsik Kim,현창림,Ji Shin Lee,고관표,이대호 전남대학교 의과학연구소 2011 전남의대학술지 Vol.47 No.2

Metastasis to the thyroid gland from distant cancer is rare, and, in some cases, is a diagnostic challenge. Here, we report a case of metastatic renal cell carcinoma of the thyroid gland. A 77-year-old man presented with a neck mass detected about 1 month previously. He had undergone a right nephrectomy owing to renal cell carcinoma 14years previously. Fine needle aspiration cytology showed a few atypical follicular cells with nuclear atypia. Under a tentative diagnosis of papillary thyroid carcinoma, a total thyroidectomy was performed. The histologic and immunohistochemical studies of the surgical specimens indicated that the thyroid masses were metastatic renal cell carcinoma to the thyroid.

Absorption Mechanism of a Physical Complex of Monomeric Insulin and Deoxycholyl-<small>l</small>-lysyl-methylester in the Small Intestine

Mahmud, Foyez,Jeon, Ok-Cheol,Al-Hilal, Taslim A.,Kweon, Seho,Yang, Victor C.,Lee, Dong Soo,Byun, Youngro American Chemical Society 2015 MOLECULAR PHARMACEUTICS Vol.12 No.6

<P>Currently, oral administration of insulin still remains the best option to avoid the burden of repeated subcutaneous injections and to improve its pharmacokinetics. The objective of the present investigation was to demonstrate the absorption mechanism of insulin in the physical complexation of deoxycholyl-<SMALL>l</SMALL>-lysyl-methylester (DCK) for oral delivery. The oral insulin/DCK complex was prepared by making a physical complex of insulin aspart with DCK through ion-pair interaction in water. For the cellular uptake study, fluorescein-labeled insulin or DCK were prepared according to a standard protocol and applied to Caco-2 or MDCK cell lines. For the PK/PD studies, we performed intrajejunal administration of different formulation of insulin/DCK complex to diabetic rats. The resulting insulin and DCK complex demonstrated greatly enhanced lipophilicity as well as increased permeation across Caco-2 monolayers. The immunofluorescence study revealed the distribution of the complex in the cytoplasm of Caco-2 cells. Moreover, in the apical sodium bile acid transporter (ASBT) transfected MDCK, the insulin/DCK complex showed interaction with ASBT, and also demonstrated absorption through passive diffusion. We could not find that any evidence of endocytosis in relation to the uptake of insulin complex in vitro. In the rat intestine model, the highest absorption of insulin complex was observed in the jejunum at 1 h and then in the ileum at 2–4 h. In PK/PD study, the complex showed a similar PK profile to that of SC insulin. Overall, the study showed that the effect of DCK on enhancing the absorption of insulin resulted from transcellular processes as well as bile acid transporter activity.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/mpohbp/2015/mpohbp.2015.12.issue-6/mp500626a/production/images/medium/mp-2014-00626a_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/mp500626a'>ACS Electronic Supporting Info</A></P>

Ferritin nanocage with intrinsically disordered proteins and affibody: A platform for tumor targeting with extended pharmacokinetics

Lee, Na Kyeong,Lee, Eun Jung,Kim, Soyoun,Nam, Gi-hoon,Kih, Minwoo,Hong, Yeonsun,Jeong, Cherlhyun,Yang, Yoosoo,Byun, Youngro,Kim, In-San Elsevier 2017 Journal of controlled release Vol.267 No.-

<P><B>Abstract</B></P> <P>Ferritin nanocages are of particular interest as a novel platform for drug and vaccine delivery, diagnosis, biomineralization scaffold and more, due to their perfect and complex symmetry, ideal physical properties, high biocompatibility, low toxicity profiles as well as easy manipulation by genetic or chemical strategies. However, a short half-life is still a hurdle for the translation of ferritin-based nanomedicines into the clinic. Here, we developed a series of rationally designed long circulating ferritin nanocages (LCFNs) with ‘Intrinsically Disordered Proteins (IDP)’ as a stealth layer for extending the half-life of ferritin nanocages. Through predictions with 3D modelling, the LCFNs were designed, generated and their pharmacokinetic parameters including half-life, clearance rate, mean residence time, and more, were evaluated by qualitative and quantitative analysis. LCFNs have a tenfold increased half-life and overall improved pharmacokinetic parameters compared to wild-type ferritin nanocages (wtFN), corresponding to the low binding against bone marrow-derived macrophages (BMDMs) and endothelial cells. Subsequently, a tumor targeting moiety, epidermal growth factor receptor (EGFR)-targeting affibody peptide, was fused to LCFNs for evaluating their potential as a theragnostic platform. The tumor targeting-LCFNs successfully accumulated to the tumor tissue, by efficient targeting <I>via</I> active and passive properties, and also the shielding effect of IDP <I>in vivo</I>. This strategy can be applied to other protein-based nanocages for further progressing their use in the field of nanomedicine.</P> <P><B>Graphical abstract</B></P> <P>Long circulating ferritin nanocages are designed by 3D modelling. Modified by intrinsically disordered protein (IDP) clouds, this novel biocompatible nanocage platform can be applied in the field of nanomedicine.</P> <P>[DISPLAY OMISSION]</P>