http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
보신 관광에서 감염된 수입성 Sparganosis 1예 : Intake of Thailand Snake during Trip
서환조,박명재,고경식,백영한,조유정,양현종,류경남,정형근,전정열 대한감염학회 1992 감염 Vol.24 No.1
Human sparganosois was reported more than 100 cases in Korean population. However no case reported yet in Korea as a patient was infected by sparganum from other geographical area, such as Thailand. The case we are reported here is a 38 year-old Korean male who had been suffered from mass being a small, round and soft consistance in upper portion of his right thigh. The patients stated that he had an opportunity to eat living snake in Bangkok, Thailand during trip. As therapy praziquantel (75㎎/㎏/day) was given p.o. for 14 days, but in vain to cure. Following medical treatment, surgical exicision was performed to remove a alive, soft, whitish-milky, mobile and elongated sparganum. Serlogical test by micro-ELISA for sparganum-specific antibody revealed a high serum antibody level of absorbance 0.67 (positive criterion: absorbance 0.22).
권운용,조유환,송형곤,김명천,이중의,서길준,윤여규 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4
Background: Paraquat causes severe tissue toxicity when ingested, but has no effective treatment modality. We have shown that high dose vitamin C has effective antioxidant activities against the paraquat intoxication in a previous animal experiment. This study was designed to evaluate the effect of antioxidant therapy with high dose vitamin C and vitamin E in human cases of paraquat intoxication. Methods: From August 1999 to August 2001, 19 paraquat intoxication patients who visited the emergency department of the Seoul National University Hospital and the Kyounghee University Hospital were enrolled to this study. They were devided into two groups, a control group(9 patients) and a study group(10 patients). The control group received only conservative managements including gastro-intestinal decontaminati-on. The study group received conservative managements plus the antioxidant therapy which was composed of vitamin C 24 gm/day intravenously and 20 gm/day orally, and vitamin E 1.6 gm/day orally. Results: In the study group, 5 of 10 patients(50%) survived, but all patients of the control group died(p=0.003). There were no significant differences in age, sex, and usage of gastric lavage and activated charcoal between the two groups. Difference in ingested amount of paraquat between the two groups could not be analyzed due to the inexact and subjective measuring methods based on patients' histories. Conclusion: Antioxidant therapy with high dose vitamin C and vitamin E is effective in vival rate in paraquat intoxicated patients.
강알칼리 중독에서 약산을 이용한 중화요법의 유용성에 대한 실험적 연구 : In-vivo Study
조유환,조익준,신중호,이중의,서길준,윤여규 대한응급의학회 2003 대한응급의학회지 Vol.14 No.1
Purpose: This study was designed to prove the efficacy of neutralization with weak acid against strong alkali ingestion and to evaluate exothermic reaction of neutralization therapy. Methods: 30 New Zealand White rabbits were anesthetized with intravenous injection of ketamine and xylazine. After gastric lavage was done, a oro-gastric catheter and a electric thermometer probe were inserted into stomach. And then the rabbits were divided into six groups. The first group was given 3M NaOH 16.5 mL only. The second and third groups were given 3M NaOH 16.5 mL and then 1M CH₃COOH 52.14 mL one and three minutes later, respectively. The fourth and fifth groups were given tap water instead of CH₃COOH, and the sixth group was given CH₃COOH only. We monitored intra-gastric temperature continuously, compared arterial pHs before alkali infusion and 15 minutes later, measured gastric pH 15 minutes later, and examined pathologic findings of stomach after sacrificing. Results: There was no significant thermal effect in all groups, and gastric pH of neutralization groups was much lower than alkali alone or dilution groups. Changes of arterial pH after 15 minutes were greater in alkali alone and dilution groups than neutralization groups. In gross and microscopic findings of stomach, only mucosal injuries were observed in neutralization groups, especially in one minute group. But all stomach layers were destroyed in alkali alone and dilution groups. Conclusion: Neutralization therapy never makes additional thermal injury, and has protective effects against local tissue destruction and systemic alkalemia. Dilution therapy shows little or no effects.
CASE REPORT : Refractory Duodenal Crohn`s Disease Successfully Treated with Infliximab
( You Lim Kim ),( Young Sook Park ),( Eun Kyoung Park ),( Dae Rim Park ),( Gyu Sik Choi ),( Sang Bong Ahn ),( Seong Hwan Kim ),( Yun Ju Jo ) 대한장연구학회 2014 Intestinal Research Vol.12 No.1
Crohn`s disease (CD) may involve any part of the gastrointestinal tract, from the mouth to the anus. Approximately >90% of cases occur in the small bowel and colon. Upper gastrointestinal involvement, especially duodenal manifestation, is relatively rare. Therefore, adequate medical treatment for duodenal CD has not yet been established. We report a case of CD with duodenal involvement. A 46-year-old man with Crohn`s ileocolitis presented to our hospital with right upper quadrant pain. An endoscopy showed a deep excavated ulcer with deformity at the duodenal bulb, and he was initially treated with azathioprine (1 mg/kg), Pentasa (3.0 g/day), and a proton pump inhibitor for 1 year. However, the deep ulcer did not heal. Therefore, infliximab infusion therapy was initiated, and the duodenal lesion completely resolved on follow-up esophagogastroduodenoscopy. We report a case of duodenal CD that completely resolved following infliximab infusion, with a review of the literature. (Intest Res 2014;12:66-69)
You, Sungyong,Yoo, Seung-Ah,Choi, Susanna,Kim, Ji-Young,Park, Su-Jung,Ji, Jong Dae,Kim, Tae-Hwan,Kim, Ki-Jo,Cho, Chul-Soo,Hwang, Daehee,Kim, Wan-Uk National Academy of Sciences 2014 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.111 No.1
<P>Rheumatoid synoviocytes, which consist of fibroblast-like synoviocytes (FLSs) and synovial macrophages (SMs), are crucial for the progression of rheumatoid arthritis (RA). Particularly, FLSs of RA patients (RA-FLSs) exhibit invasive characteristics reminiscent of cancer cells, destroying cartilage and bone. RA-FLSs and SMs originate differently from mesenchymal and myeloid cells, respectively, but share many pathologic functions. However, the molecular signatures and biological networks representing the distinct and shared features of the two cell types are unknown. We performed global transcriptome profiling of FLSs and SMs obtained from RA and osteoarthritis patients. By comparing the transcriptomes, we identified distinct molecular signatures and cellular processes defining invasiveness of RA-FLSs and proinflammatory properties of RA-SMs, respectively. Interestingly, under the interleukin-1β (IL-1β)–stimulated condition, the RA-FLSs newly acquired proinflammatory signature dominant in RA-SMs without losing invasive properties. We next reconstructed a network model that delineates the shared, RA-FLS–dominant (invasive), and RA-SM–dominant (inflammatory) processes. From the network model, we selected 13 genes, including periostin, osteoblast-specific factor (POSTN) and twist basic helix–loop–helix transcription factor 1 (TWIST1), as key regulator candidates responsible for FLS invasiveness. Of note, POSTN and TWIST1 expressions were elevated in independent RA-FLSs and further instigated by IL-1β. Functional assays demonstrated the requirement of POSTN and TWIST1 for migration and invasion of RA-FLSs stimulated with IL-1β. Together, our systems approach to rheumatoid synovitis provides a basis for identifying key regulators responsible for pathological features of RA-FLSs and -SMs, demonstrating how a certain type of cells acquires functional redundancy under chronic inflammatory conditions.</P>
마비성 조음장애 환자에서 언어치료 기능성 게임 적용 후 호전 양상에 대한 연구
조윤주(Jo Yun Ju),김기욱(Kim Gi Wook),유희천(You Hee Cheon),Xiaopeng Yang,최영근(Choi Young Geun),김현기(Kim Hyun Gi),고명환(Ko Myoung Hwan) 한국언어치료학회 2016 한국언어치료학회 학술발표대회 논문집 Vol.2016 No.12
Purpose: We developed a serious speech game for rehabilitation of the patients with dysarthria. The Smart Speech Program is composed of a three categories such as continuity, pitch, and loudness. The purpose of this study was to examine the usefulness of smart speech programs in speech therapy of patients with dysarthria by evaluating changes in voice. Methods: Fifteen patients with dysarthria disorder and without aphasia suffered from brain diseases were enrolled. The study started with “pre-evaluation 1, and then, evaluations were repeated pre-evaluation 2 after 6 weeks without any treatment in order to generated the control data. After pre-evaluation, a smart speech program was used to perform training. Post-training evaluation 1 were performed just after treatment. And, after six weeks of daily life, conducted a post-training evaluation 2 to see if treatment remained effective. The evaluation used the multi-dimensional voice program of the computerized speech laboratory to collect voice samples-pitch, intensity, fundamental frequency(F0), maximum phonation time(MPT), jitter, relative average perturbation(RAP), and the articulation parameters were measured by the Urimal Test of Articulation and Phonology(U-TAP) and the 3-Position Articulation Test. Results: In the post-training evaluation 1, pitch range(pitch max.-pitch min.), F0, intensity, MPT, jitter, RAP and U-TAP scores of all subjects showed significant results(p<0.05). In the post-training evaluation 2, significant changes were retained in pitch range and U-TAP scores, both of which had a long-term effect. Conclusions: These preliminary results suggest that the newly developed serious game for speech training has a positive effects on pitch, loudness, and articulation abilities in the patients of dysarthria. Therefore, it was found that smart speech was effective in improving speech ability and articulation of dysarthria patients.