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Ji Chang Woo,Kim Nam-Jung,Lee Sang-Guei,Hwang-Yong Kim,Choi Hoon-Sik,Song In-Sun,Ko Jee Sun 한국응용곤충학회 2010 한국응용곤충학회 학술대회논문집 Vol.2010 No.05
We analyzed the chirp sound and behavior of Teleogryllus emma with observation system, which was consisted of computer, ccd-camera and microphone. Computational methods of wavelet transformation and Self-Organizing Maps (SOM) were utilized to characterized the chirp sound of insect species for automatic counting in this study. Wavelets were initially applied to feature extraction of the chirp sound. Wavelet coefficients were accordingly calculated based on the basis function (e.g., Morlet). The obtained coefficients were subsequently provided to count number of chirps in each song. Sound structure of insect specimens consisted with long chirp and short chirp and the patterns of song were grouped by frequency of long chirp and short chirp. The song patterns of insect specimens were divided by Self-Organizing Map (SOM) that was used number of chirp as input data. Application of computational methods to automatic detection of chirp sound was further discussed for obtaining objective assessment in behavior science.
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유산소성 운동이 노인들의 신체조성과 등속성 슬관절 근력 및 요부근력에 미치는 영향
한종우(Jong Woo Han),이상석(Sang Sug Lee),송분도(Bun Do Song),지용석(Yong Suk Ji),김난수(Nan Su Kim),서경호(Kyeong Ho Seo) 한국사회체육학회 2000 한국사회체육학회지 Vol.13 No.-
This study was designed to investigate the effect of a year aerobic exercise training on body composition, isokinetic knee and trunk muscular strength of elders. The subjects for this study were eighty healthy elderly people who were members of seniors tower at Song-Do Hospital and didn`t have any history of cardiorepiratory disease. Subjects have been trained three times a week for a year. The exercise program was made up of a 15-minute warm-up, cool-down. Stretching was performed every eight minutes for the prevention of injuries which could occur during the main exercise and quick recovery of the used muscle. Aerobic training was performed for each 15-20minutes using the treadmill and cycle ergometer at the intensity of 50-70% HRmax. For the data, all the measurements were represented by mean and standard deviation using SAS package(version 6.12). Statistical techniques for data analysis were paired t-test to determine the difference between pre and post exercise program. The 5% level of significance was used as the critical level for acceptance of hypotheses for the study. The following results were obtained from this study. 1. There is a statistically significant difference in the VO_2max, fat mass, lean mass and %body fat both old men and women after a year training. 2. There is not a statistically significant difference in the weight, WHR and thigh circumference both old men and women after a year training. 3. There is a statistically significant difference in the right knee flexor/extensor peak torque, peak torque % body weight, total work and total work % body weight both old men and women after a year training. 4. There is a statistically significant difference in the left knee flexor/extensor peak torque, peak torque % body weight, total work and total work % body weight both old men and women after a year training.
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Comparison of malignant potential between serrated adenomas and traditional adenomas
Song, Sang Yong,Kim, Young-Ho,Yu, Min Kyu,Kim, Jeong Hwan,Lee, Ji Min,Son, Hee Jung,Rhee, Poong-Lyul,Kim, Jae J,Paik, Seung Woon,Rhee, Jong Chul Blackwell Publishing Asia 2007 Journal of gastroenterology and hepatology Vol.22 No.11
<P>Abstract</P><P>Background: </P><P>Serrated adenoma is a discrete colorectal epithelial neoplastic lesion that can evolve into colorectal cancer. However, the degree of malignant potential has not been firmly established as yet. The purpose of the present paper was to compare the malignant potential and clinicopathological features between serrated and traditional adenomas.</P><P>Methods: </P><P>A total of 124 serrated adenomas from 116 patients were assessed, and 419 traditional adenomas from 200 were randomly selected. The combination of nuclear dysplasia and serration of ≥20% of crypts was regarded as serrated adenoma. The clinicopathological features of serrated and traditional adenomas were compared, and multivariate analysis performed to confirm whether the malignant potential of serrated adenoma was similar to that of traditional adenoma.</P><P>Results: </P><P>The differences in age, sex, total number of adenomas, and synchronous lesions including adenoma with high-grade dysplasia and carcinoma between subjects with and without serrated adenoma were not significant. Serrated adenomas were more frequently located in the rectum and sigmoid colon (<I>P</I> < 0.001), and the average size of serrated adenomas was greater than that of traditional adenomas (<I>P</I> < 0.05). The incidence of malignant lesions including high-grade dysplasia and carcinoma in serrated adenomas was found to be lower than in traditional adenomas (3.2% vs 9.3%, <I>P</I> < 0.05). In the multivariate analysis, adenoma type and polyp size constituted the risk factors for the incidence of high-grade dysplasia and carcinoma.</P><P>Conclusions: </P><P>Serrated adenoma is a premalignant lesion, but it has a lower potential for the development of malignancy than traditional adenomas.</P>
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Sung, Jae Hyuck,Kim, Choong Yong,Yang, Seoung Oh,Khang, Hyun Soo,Cheong, Hae Kwan,Lee, Jong Seong,Song, Chang-Woo,Park, Jung Duck,Han, Jeong Hee,Chung, Yong Hyun,Choi, Byung Sun,Kwon, Il Hoon,Cho, Myu Informa Healthcare 2007 Inhalation toxicology Vol.19 No.1
<P> Welders are at risk of being exposed to high concentrations of welding fumes and developing pneumoconiosis or other welding-fume exposure-related diseases. Among such diseases, manganism resulting from welding-fume exposure remains a controversial issue, as although the movement of manganese into specific brain regions has been established, the similar movement of manganese presented with other metals, such as welding fumes, has not been clearly demonstrated as being similar to that of manganese alone. Meanwhile, the competition between Mn and iron for iron transporters, such as transferrin and DMT-1, to the brain has also been implicated in the welding-fume exposure. Thus, the increased signal intensities in the basal ganglia, including the globus pallidus and subcortical frontal white matter, based on T1-weighted magnetic resonances in welders, require further examination as regards the correspondence with an increased manganese concentration. Accordingly, to investigate the movement of manganese after welding-fume exposure, 6 cynomolgus monkeys were acclimated for 1 mo and assigned to 3 dose groups: unexposed, low dose of (total suspended particulate [TSP] 31 mg/m3, 0.9 mg/m3 of Mn), and high dose of total suspended particulate (62 mg/m3 TSP, 1.95 mg/m3 of Mn). The primates were exposed to manual metal-arc stainless steel (MMA-SS) welding fumes for 2 h/day in an inhalation chamber system equipped with an automatic fume generator for 6 mo. Magnetic resonance imaging (MRI) studies of the basal ganglia were conducted before the initiation of exposure and thereafter every month. During the exposure, the blood chemistry was monitored every 2 wk and the concentrations of metal components in the blood were measured every 2 wk and compared with ambient manganese concentrations. The manganese concentrations in the blood did not show any significant increase until after 2 mo of exposure, and then reached a plateau after 90 days of exposure, showing that an exposure period of at least 60 days was required to build up the blood Mn concentration. Furthermore, as the blood Mn concentration continued to build, a continued decrease in the MRI T1 relaxation time in the basal ganglia was also detected. These data suggested that prolonged inhalation of welding fumes induces a high MRI T1 signal intensity with an elevation of the blood manganese level. The presence of a certain amount of iron or other metals, such as Cr and Ni, in the inhaled welding fumes via inhalation was not found to have a significant effect on the uptake of Mn into the brain or the induction of a high MRI T1 signal intensity.</P>
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Alliance Portfolio and Knowledge Acquisition
Sang Ji Kim,Jae Yong Song 한국경영학회 2014 한국경영학회 통합학술발표논문집 Vol.2014 No.8
This paper studies on factors influencing the relationship between a focal firm’s R&D alliance portfolio diversity and its knowledge acquisition from the portfolio. Drawing upon organizational learning theory and transaction cost economics, I tested the effect of technological diversity of a firm``s R&D alliance portfolio on its knowledge acquisition and examined the condition that a focal firm can raise benefit while reducing costs generated from the diversity of alliance portfolio in order to investigate the cost-effective composition of R&D alliance portfolio with data of high-tech manufacturing firms during the period 1987-2013. For empirical tests, I constructed a data set comprising the R&D alliance and patenting activities of firms in four high-tech manufacturing industries: semiconductor, electronics, computer manufacturing, and telecommunications industries. I construct the data set from the SDC (Securities Data Company) Database on Joint Ventures and Alliances and the USPTO (United States Patent and Trademark Office) database. The results of the study shows that alliance are important to the global high-tech manufacturing industries to source diverse external knowledge and accelerate firm innovation as the data represents, but the learning benefits diminish with too much diversity in alliance portfolios due to increasing transaction costs. This study also highlight the trade-offs in managing diverse alliance portfolio between learning benefits and managerial complexity and costs. Greater technological diversity of alliance portfolios can be beneficial and contribute to knowledge acquisition of a focal firm when the firm includes technologically and culturally close partners in its R&D alliance portfolio.
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Yong Jin Park,Lee Jin Lim,Hee Sang Song 대한환경공학회 2013 Environmental Engineering Research Vol.18 No.3
This study was performed to examine the in vitro toxicities which are incurred due to the mobilization metals from standard reference material (SRM) 1648, fine (PM2.5), and coarse (PM10) particulate matter collected in Seoul metropolitan area. DNA single strand breaks of approximately 74% and 62% for PM2.5 and for PM10, respectively, were observed in the presence of chelator (EDTA or citrate)/ reductant (ascorbate), as compared to the control by 2% without chelator or reductant. PM2.5 induced about 40% more carbonyl formation with proteins in the presence of EDTA/ascorbate than PM10. Therefore, more damage to biomolecules was incurred upon exposure to PM2.5 than to PM10. The treatment of a specific chelator, desferrioxamine, to the reaction mixture containing chelator plus reductant decreased the extent of damage to DNA to the level of the control, but did not substantially decrease the extent of damage to proteins. This suggests that different arrays of metals were involved in the oxidation of DNA and proteins.
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Allelic Deletions of Chromosomes in Human Colorectal Cancer Development
Song, Young Tack,Kim, Seung Nam,Lee, Jai Hak,Yoo, Seung Jin,Cho, Won Il,Chang, Suk Kyun,Choo, Sang Yong CATHOLIC MEDICAL CENTER 1993 Bulletin of the Clinical Research Institute Vol.21 No.2
Two types of genetic alterations have been reported in colorectal tumors. The first type involves point mutations in ras proto-oncogenes. The second type of alterations involves detection of specific chromosomal regions. Deletions can be detected by restriction fragment length polymorphism analyisis of tumor DNA. The deleted sequences have been hypothesized to include tumor suppressor gene. The inactivation of tumor-suppressor gene by deletion of suspected locus lead to neoplatic growth. To investigate the relation between ras point mutation and allelic deletion of chromosome 17p and 18q, both p-PCR and RELP analysis using VNTR marker and synthetic oligonulectide probe tailing with digoxigenin Ⅱ-dUTP were done in 15 normal mucosa and 22 colorectal cancer mucosa. The obtained results were as follows: 1. Incidence of ras point mutations was 80% (4/5) in Dukes’ B, 82.3% (14/17) in Dukes’ C. There was increasing tendency of mutation along with stage progression, but no statistical significance was noted. 2. Incidence of ras point mutations were 45.4% (5/11) in well differentiated cancer and 77.7% (7/9) in moderately differentinted cancer. 3. Incidence of allelic diletion of 17p pYNH37 were 80% (5/11) in Dukes’ B, 64,7% (l1/17) in Dukes’ C. There was no correlation of incidences of 18q OS-4 in colorectal cancer. But incidence of 17p allelic deletion was higher than 18q allelic deletion in Dukes’ C colorectal cancer. The allelic deletions of pYNZ22 were noted in 6 cases of Dukes’ C colorectal cancer but not in Dukes’ B colorectal cancer. 4. There was no statistical difference between incidence of ras point mutation and allelic deletion in colorectal cancer. These results showed there was no statistical difference in incidence of ras point mutation & 18q allelic deletion in colorectal cancer. 17p allelic deletion occurred more frequently in advanced colorectal cancer. Genetic alteration did not have any correlation with cellular differentiation or tumor location in the biologic behavior of the colorectal cancer.
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