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Hui Wu,Ting Xu,Xiao Wang,Yong-Bo Yu,Zhong-Yuan Fan,Dan-Xia Li,Lei Luo,Xue-Cheng Yang,Wei Jiao,Hai-Tao Niu 대한남성과학회 2020 The World Journal of Men's Health Vol.38 No.2
Purpose: To compare the diagnostic efficiency of 68Gallium labelled prostate-specific membrane antigen positron emission tomography (68Ga-PSMA PET) and magnetic resonance imaging (MRI) for staging the lymph node metastases (LNMs) in the prostate cancer. Materials and Methods: A broad search of scientific databases including PubMed, EMBASE, Web of Science, Cochrane Database, and Chinese Biomedicine Literature Database (updated prior to November 1st, 2018) was conducted systematically by two reviewers. In this paper, we evaluated the methodological quality of each included article independently and performed a systematic review and meta-analysis to reveal the summary of the diagnostic performance of 68Ga-PSMA PET and MRI in properly identifying LNMs of intermediate- and/or high-risk prostate cancer.Results: Thirteen eligible articles comprising 1,597 patients were included. For LNMs detection, the pooled sensitivity and specificity of 68Ga-PSMA PET were 0.65 (95% confidence interval [CI]: 0.49–0.79) and 0.94 (95% CI: 0.88–0.97), respectively, while the corresponding values of MRI were 0.41 (95% CI: 0.26–0.57) and 0.92 (95% CI: 0.86–0.95). The area under the symmetric receiver-operating characteristic (SROC) curve for 68Ga-PSMA PET and MRI were 0.92 and 0.83, respectively. Conclusions: In intermediate- or high-risk pre-treatment prostate cancer, 68Ga-PSMA PET had a higher sensitivity and a slightly different specificity in probing the LNMs when comparing with MRI. Moreover, the area under the SROC curve indicated that 68Ga-PSMA PET was a more effective weapon for predicting the LNMs prior to radical surgery.
Horibe, Yoichi,Yang, Junjie,Cho, Yong-Heum,Luo, Xuan,Kim, Sung Baek,Oh, Yoon Seok,Huang, Fei-Ting,Asada, Toshihiro,Tanimura, Makoto,Jeong, Dalyoung,Cheong, Sang-Wook American Chemical Society 2014 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.136 No.23
<P>Common mathematical theories can have profound applications in understanding real materials. The intrinsic connection between aperiodic orders observed in the Fibonacci sequence, Penrose tiling, and quasicrystals is a well-known example. Another example is the self-similarity in fractals and dendrites. From transmission electron microscopy experiments, we found that FexTaS2 crystals with x = 1/4 and 1/3 exhibit complicated antiphase and chiral domain structures related to ordering of intercalated Fe ions with 2a x 2a and root 3a x root 3a superstructures, respectively. These complex domain patterns are found to be deeply related with the four color theorem, stating that four colors are sufficient to identify the countries on a planar map with proper coloring and its variations for two-step proper coloring. Furthermore, the domain topology is closely relevant to their magnetic properties. Our discovery unveils the importance of understanding the global topology of domain configurations in functional materials.</P>
Knockout of the EgriBLOS2 gene results in the transparent integuments of Ectropis grisescens larvae
Li Jia-Li,Zhuang Xiang-Lin,Yuan Ting-Ting,Cai Xiao-Ming,Luo Zong-Xiu,Bian Lei,Chen Zong-Mao,Li Zhao-Qun,Liu Nai-Yong 한국응용곤충학회 2022 Journal of Asia-Pacific Entomology Vol.25 No.1
The body colors of insects have evolved specialized roles in body protection, signaling and physiology. In some case, the larvae can camouflage their body colors to adapt the habitants and protect themselves. However, the genetic and molecular basis on larval body colors of the tea geometrid, Ectropis grisescens, remains poorly known. Here, we reported an effect of the lysosome-related organelles complex-1, subunit 2 (EgriBLOS2) gene knockout on larval integuments of E. grisescens, by using a clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) system. Combining transcriptomic data and PCR approaches, we first identified the EgriBLOS2 gene from E. grisescens, which encoded 137 amino acids and comprised 3 introns. In the phylogenetic analysis, EgriBLOS2 clustered in the Lepidoptera clade with high conservation to members in other lepidopteran species. Developmental expression profiles revealed that EgriBLOS2 was constantly tran scribed at each stage, in which its expression was significantly lower in 2nd instar larvae than that of other instars. After injecting EgriBLOS2-specific guide RNA and Cas9 messenger RNA into eggs, 70% of larvae showed the translucent integuments in G0 generation, with an emphasis on black splayed patterns in the 2nd and 8th segments of abdomens. However, some typical characteristics of larvae were not obviously changed in mutant instars, such as ocelli, mouthparts and other appendants. This study has unraveled the roles of EgriBLOS2 in the formation of larval integument colors, and provides an alternative strategy for pest management based on the colors in this species.
An improved algorithm for pile damage localization based on complex continuous wavelet transform
Jing-Liang Liu,Cheng-Xu Lin,Xi-Jun Ye,Wen-Ting Zheng,Yong-Peng Luo 국제구조공학회 2021 Smart Structures and Systems, An International Jou Vol.27 No.3
Since the complex continuous wavelet transform (CCWT) based pile damage detection method is empirical and subjective, an improved algorithm for pile damage localization based on CCWT is proposed by introducing K-means clustering and fast Fourier transform (FFT). In this method, the K-means clustering algorithm is used to accurately calculate the time coordinates of two energy concentrating points caused by the incident and reflected waves, respectively. Meanwhile, FFT is employed to estimate the concerned frequency band of the response signal. Therefore, a specific region in the time frequency plane is defined objectively and it can be used to search the phase angle turning points and localize pile damage. The proposed method is verified by numerical examples of piles with single and multiple damage positions. A parameter analysis is also conducted to investigate how damage depth and damage degree in piles affect the accuracy and effectiveness of the proposed method. The results demonstrate that the proposed method is able to localize a pile with a damage at least 2.5 m away from the pile head when the damage degree is as less as 5%. After that, dynamic tests of an actual square reinforced concrete pile and an actual circular reinforced concrete pile are investigated to verify the application of the proposed method on practical engineering. Although the proposed method is capable of localizing actual piles more accurately than the CCWT method, the problem of interference points needs to be addressed by mutual verification with other pile damage localization methods.