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Yi‑Chia Kuan,Venkatesan Thiruvengadam,Jia‑Shin Lin,Jia‑Hsin Liu,Tsan‑Jan Chen,Hsin‑Mao Wu,Wen‑Ching Wang,Liang‑Jwu Chen 한국식물생명공학회 2018 Plant biotechnology reports Vol.12 No.1
The broad-specificity amino acid racemase (Bsar) from Pseudomonas putida catalyzes the racemization of various amino acids, offering a flexible and feasible platform to develop a new non-antibiotic selectable marker system for plant transformation. In the present study, we demonstrated that a Bsar variant, Bsar-R174K, that is useful as a selectable marker gene in Arabidopsis and rice that were susceptible to l-lysine and D-alanine. The introduction of wild-type Bsar, Bsar-R174K or Bsar-R174A into E. coli lysine or asparagine auxotrophs was able to rescue the growth of these microorganisms in minimal media supplemented with selectable amino acid enantiomers. The transformation of Arabidopsis with Bsar or Bsar variants based on d-alanine selection revealed that Bsar-R174K had the greatest efficiency (2.40%), superior to kanamycin selectionbased transformation (1.10%). Whereas, l-lysine-based selection exhibited lower efficiency for Bsar-R174K (0.17%). The progenies of selected Bsar-R174K transgenic Arabidopsis revealed normal growth properties. In addition, Bsar-R174K transgenic rice was obtained on l-lysine medium with an efficiency of 0.9%, and the progenies of the transgenic rice revealed morphologically normal phenotypes comparable with their wild-type counterparts. This study presents the first report of broad range amino acid racemase Bsar-R174K as a non-antibiotic selectable marker system applied in transgenic plants.
SAFE TECHNOLOGY WITH A NOVEL REAR COLLISION AVOIDANCE SYSTEM OF VEHICLES
Yi-Shun Chen,Sheng-Chien Chiu,Shu-San Hsiau 한국자동차공학회 2019 International journal of automotive technology Vol.20 No.4
This study aims to reduce the severity of injuries caused by and the frequency of rear-end vehicle collisions. A better collision prediction method is proposed by means of millimeter-wave radar sensors able to rapidly detect potential collisions and alert drivers. Implementation of the system would bring about a reduction in accidents and potentially reduce the severity of the accidents that cannot be avoided. The proposed collision avoidance system adopted millimeter-wave radar sensors to collect information on vehicle’s rear surroundings. The designed experimental device has several unique features. The device has a wide monitoring range, incorporates a continuous detection process, and contains a rapid warning system. A series of real-world experiments were performed on cars (Model: Tercel 1.5, Toyota) to demonstrate the monitoring efficiency and warning frequency of this device under several operating conditions. This study furthered the development of a safe technology for avoidance of rear-end collisions, and this offers a novel system which can be used in a variety of vehicles to reduce the frequency of rear-end vehicle collisions.
( Chen-hua Liu ),( Chi-yi Chen ),( Wei-wen Su ),( Chun-jen Liu ),( Ching-chu Lo ),( Ke-jhang Huang ),( Jyh-jou Chen ),( Kuo-chih Tseng ),( Chi-yang Chang ),( Cheng-yuan Peng ),( Yu-lueng Shih ),( Chia 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.4
Background/Aims: Real-world studies assessing the effectiveness and safety of sofosbuvir/velpatasvir (SOF/VEL) plus ribavirin (RBV) for Child-Pugh B/C hepatitis C virus (HCV)-related cirrhosis are limited. Methods: We included 107 patients with Child-Pugh B/C HCV-related cirrhosis receiving SOF/VEL plus RBV for 12 weeks in Taiwan. The sustained virologic response rates at off-treatment week 12 (SVR<sub>12</sub>) for the evaluable population (EP), modified EP, and per-protocol population (PP) were assessed. The safety profiles were reported. Results: The SVR<sub>12</sub> rates in the EP, modified EP and PP were 89.7% (95% confidence interval [CI], 82.5-94.2%), 94.1% (95% CI, 87.8-97.3%), and 100% (95% CI, 96.2-100%). Number of patients who failed to achieve SVR<sub>12</sub> were attributed to virologic failures. The SVR<sub>12</sub> rates were comparable regardless of patient characteristics. One patient discontinued treatment because of adverse events (AEs). Twenty-four patients had serious AEs and six died, but none were related to SOF/VEL or RBV. Among the 96 patients achieving SVR<sub>12</sub>, 84.4% and 64.6% had improved Child-Pugh and model for endstage liver disease (MELD) scores. Multivariate analysis revealed that a baseline MELD score ≥15 was associated with an improved MELD score of ≥3 (odds ratio, 4.13; 95% CI, 1.16-14.71; P=0.02). Patients with chronic kidney disease (CKD) stage 1 had more significant estimated glomerular filtration rate declines than patients with CKD stage 2 (-0.42 mL/min/1.73 ㎡/month; P=0.01) or stage 3 (-0.56 mL/min/1.73 ㎡/month; P<0.001). Conclusions: SOF/VEL plus RBV for 12 weeks is efficacious and well-tolerated for Child-Pugh B/C HCV-related cirrhosis. (Clin Mol Hepatol 2021;27:575-588)
Chen, Hung-Yi,Wu, Hsiao-Chung Korean Institute of Industrial Engineers 2009 Industrial Engineeering & Management Systems Vol.8 No.4
A revenue sharing contract is one of the mechanisms that coordinate decision makers in a decentralized supply chain toward the consensual goal. The transfer prices between different echelons in the supply chain influence the total supply chain profits. The study aims to explore various transfer pricing heuristics on the supply chain coordination in terms of the supply chain profits and their interactions with the revenue sharing rate. A model is proposed for formulating the collaborative production and distribution planning in a decentralized supply chain with the revenue sharing mechanism. Experiment results indicate that the transfer price and the revenue sharing rate affect significantly the coordination. Among the studied pricing heuristics, the variable-cost pricing method led to the best SC profits. Raising the revenue sharing rate reduced the SC profits no matter what heuristics were employed. Furthermore, the experiments provide us clues for finding the optimal transfer price for the supply chain.
Study on the detection behavior of defect-rich single-walled carbon nanotubes toward perchlorate
Chen, Yi,Nguyen, Thuy Hang,Zhang, Shao Lin,Zhang, Z.,Yue, Hongyan,Jian, Jiawen,Yang, Woo-Chul World Scientific Publishing Company 2018 Functional materials letters Vol.11 No.2
<P>Defect-rich single-walled carbon nanotubes (SWCNTs) were prepared by a water vapor flow-assisted chemical vapor deposition process. The correlation between defect density and water flow was quantitively studied using Raman spectrum. The detection capabilities of defective SWCNTs films toward perchlorate anions were investigated. It was found the defect-rich SWCNTs could adsorb more perchlorate anions owing to the strong chemical bonding between anions and defective sites. However, the detective response of defective SWCNTs toward perchlorate was not in compliance with anion adsorption. A tradeoff phenomenon between response and adsorption was found as the defect density of SWCNTs increased. This work is expected to provide a guidance to the future design of SWCNTs based ion detector.</P>
Optimal Lot-sizing and Pricing with Markdown for a Newsvendor Problem
Chen, Jen-Ming,Chen, Yi-Shen,Chien, Mei-Chen Korean Institute of Industrial Engineers 2008 Industrial Engineeering & Management Systems Vol.7 No.3
This paper deals with the joint decisions on pricing and ordering for a monopolistic retailer who sells perishable goods with a fixed lifetime or demand period. The newsvendor-typed problem is formulated as a two-period inventory system where the first period represents the inventory of fresh or new-arrival items and the second period represents the inventory of items that are older but still usable. Demand may be for either fresh items or for somewhat older items that exhibit physical decay or deterioration. The retailer is allowed to adjust the selling price of the deteriorated items in the second period, which stimulates demand and reduces excess season-end or stale inventory. This paper develops a stochastic dynamic programming model that solves the problem of preseason decisions on ordering-pricing and a within-season decision on markdown pricing. We also develop a fixed-price model as a benchmark against the dual-price dynamic model. To illustrate the effect of the dual-price policy on expected profit, we conduct a comparative study between the two models. Extension to a generalized multi-period model is also discussed.
( Chen Wang Chang ),( Shu Chen Wei ),( Jen Wei Chou ),( Tzu Chi Hsu ),( Chiao Hsiung Chuang ),( Ching Pin Lin ),( Wen Hung Hsu ),( Hsu Heng Yen ),( Jen Kou Lin ),( Yi Jen Fang ),( Horng Yuan Wang ),( 대한장연구학회 2014 Intestinal Research Vol.12 No.4
Background/Aims: Only moderate to severe Crohn`s Disease (CD) patients without a satisfactory conventional therapy effect are eligible to get reimbursement from the National Health Insurance of Taiwan for using adalimumab. These are more stringent criteria than in many Western countries and Japan and Korea. We aim to explore the efficacy of using adalimumab in CD patients under such stringent criteria. Methods: A retrospective analysis was conducted in nine medical centers in Taiwan and we collected the results of CD patients receiving adalimumab from Sep 2009 to Mar 2014. The clinical characteristics, response measured by CDAI (Crohn`s Disease Activity Index), adverse events and survival status were recorded and analyzed. CR-70, CR-100, and CR-150 were defined as attaining a CDAI decrease of 70, 100 or 150 points compared with baseline. Results: A total of 103 CD patient records were used in this study. Sixty percent of these patients received combination therapy of adalimumab together with immunomodulators. CR-70 was 68.7%, 74.5% and 88.4% after week 4, 8 and 12 of treatment, respectively. The steroid-free rate, complications and survival were 47.6%, 9.7% and 99% of patients, respectively. In considering the mucosal healing, only 25% patients achieve mucosal healing after treatment for 6 to12 months. Surgery was still needed in 16.5% of patients. Combination treatment of adalimumab with immunomodulators further decreased the level of CDAI at week 8 when compared with the monotherapy. Conclusions: Even under the stringent criteria for using adalimumab, the response rate was comparable to those without stringent criteria. (Intest Res 2014;12:287-292)
Yi Liu,Wu Ai,Bing Chen,Ke Chen 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.1
This paper presents a stand-alone variable speed constant frequency (VSCF) ship shaft generator system based on a brushless doubly-fed machine (BDFM). In this system, the output voltage amplitude and frequency of the BDFM are kept constant under a variable rotor speed and load by utilizing a well-designed current vector controller to regulate the control winding (CW) current. The control scheme is proposed, and the hardware design for the control system is developed. The proposed generator system is tested on a 325 TEU container vessel, and the test results show the good dynamic performance of the CW current vector controller and the whole control system. A harmonic analysis of the output voltage and a fuel consumption analysis of the generator system are also implemented. Finally, the total efficiency of the generator system is presented under different rotor speeds and load conditions.