Involvement of MicroRNA-198 Overexpression in the Poor Prognosis of Esophageal Cancer

Qi, Bo,Yao, Wen-Jian,Zhao, Bao-Sheng,Qin, Xiu-Guang,Wang, Yi,Wang, Wen-Ju,Wang, Tian-Yun,Liu, Shang-Guo,Li, Han-Chen Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9

Objective: This study aimed to investigate whether the miR-198 expression level is related to clinicopathological factors and prognosis of esophageal cancer. Methods: MicroRNA was extracted from esophageal cancer patients who underwent surgery for assessment using the Taqman@ MicroRNA assay. The correlation between miR-198 expression and clinicopathological features was analyzed, and the significance of miR-198 as a prognostic factor and its relationship with survival was determined. Results: MicroRNA-198 (miR-198) expression was higher in patients with poor prognosis than those with good prognosis (P<0.05). Kaplan-Meier analysis results showed that the miR-198 expression level had a significant correlation with survival time (P=0.030) and that patients with a higher expression of miR-198 had a shorter survival time. Cox multi-factor model analysis showed that patient prognosis (P=0.014), tumor length (P=0.040) and expression (P=0.012), and survival time had a significant correlation; the corresponding risks were 7.268, 1.246, and 3.524, respectively. Conclusion: miR-198 overexpression is involved in the poor prognosis of esophageal cancer and can be used as a biomarker for selection of cases requiring especial attention.

Optimization of Brazing Conditions for OFHC Cu and ASTM A501 Low Carbon Steel by Taguchi Method

Yi Qi Wang,Ali Md. Afsar,송정일 한국정밀공학회 2009 International Journal of Precision Engineering and Vol. No.

This paper concerns the optimization of brazing conditions for joining the two dissimilar materials Oxygen-free high conductivity (OFHC) copper and ASTM A501 low carbon steel usually used for an Oil-Separator of an airconditioner using Ag-based (BAg) alloy as a brazing filler metal (BFM). A mixture of 70% N2 and 30% H2 gases was used to prevent oxidation of the joints during furnace brazing process. Brazing joint clearance, length, temperature, and time were selected as design parameters that have significant effect on the bonding strength of a brazed joint. Taguchi method was used as a statistical technique for design of experiment (DOE) in an attempt to optimize brazing conditions in terms of shear strength. L9 (34) orthogonal array was designed for conducting the experiments. The relative influence of design parameters and their interaction on the response were also discussed. The experimental results verified that the brazing conditions predicted in this study by Taguchi method could produce the brazed joint between OFHC copper and ASTM A501 low carbon steel with maximum shear strength.

Towards high-accuracy data modelling, uncertainty quantification and correlation analysis for SHM measurements during typhoon events using an improved most likely heteroscedastic Gaussian process

Qi’ang Wang,Zhi-Jun Liu,Hao-Bo Wang,Zhanguo Ma,Yi-Qing Ni,Jian Jiang,Rui Sun,Hao-Wei Zhu 국제구조공학회 2023 Smart Structures and Systems, An International Jou Vol.32 No.4

Data modelling and interpretation for structural health monitoring (SHM) field data are critical for evaluating structural performance and quantifying the vulnerability of infrastructure systems. In order to improve the data modelling accuracy, and extend the application range from data regression analysis to out-of-sample forecasting analysis, an improved most likely heteroscedastic Gaussian process (iMLHGP) methodology is proposed in this study by the incorporation of the outof- sample forecasting algorithm. The proposed iMLHGP method overcomes this limitation of constant variance of Gaussian process (GP), and can be used for estimating non-stationary typhoon-induced response statistics with high volatility. The first attempt at performing data regression and forecasting analysis on structural responses using the proposed iMLHGP method has been presented by applying it to real-world filed SHM data from an instrumented cable-stay bridge during typhoon events. Uncertainty quantification and correlation analysis were also carried out to investigate the influence of typhoons on bridge strain data. Results show that the iMLHGP method has high accuracy in both regression and out-of-sample forecasting. The iMLHGP framework takes both data heteroscedasticity and accurate analytical processing of noise variance (replace with a point estimation on the most likely value) into account to avoid the intensive computational effort. According to uncertainty quantification and correlation analysis results, the uncertainties of strain measurements are affected by both traffic and wind speed. The overall change of bridge strain is affected by temperature, and the local fluctuation is greatly affected by wind speed in typhoon conditions.

Room Temperature Dry and Lubricant Wear Behavior of Al₂O₃<SUB>f</SUB>/SiC<SUB>p</SUB> Hybrid Metal Matrix Composites

Yi Qi Wang,Yu Shi,Ali Md. Afsar,Jung-Il Song 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.5

Wear behavior of Al₂O₃<SUB>f</SUB> and SiC<SUB>p</SUB> hybrid MMCs are investigated with a view to analyzing the effects of fiber orientations and hybrid ratios under room temperature. The MMCs were fabricated with different hybrid ratios by squeeze casting method. The tests were carried out for both the dry and lubricant conditions using a pin-on-disk friction and wear tester. The dry test results showed that the F20P0 MMCs with N-orientation of fibers had better wear behavior than those with PR-orientation. However, for hybrid MMCS, the wear behavior was better for PR-orientation. The lubricant wear behavior showed that the F20P0 MMCs were better with PR-orientation and hybrid MMCs were better with N-orientation of fibers.

Safety and antifatigue effect of Korean Red Ginseng capsule: A randomized, double-blind and placebo-controlled clinical trial

Yi Yang,Hong Wang,Ming Zhang,Mengxue Shi,Cailing Yang,Qiang Ni,Qi Wang,Jing Li,Xuemei Wang,Chen Zhang,Zhi Li 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.4

Background: In physical activity or labor, the human body is in a state of high intensity stress, and allparts or physiological functions of the body respond positively to maintain or balance the need formovement. The human body has many physiological changes in the process of movement, and fatigue isthe external manifestation of various complex changes inside the human body. Fatigue is also a physiologicalmechanism of self-protection after the body reaches a certain level of activity, which can preventthe occurrence of life-threatening excessive functional failure. The generation of fatigue is a very complexprocess, and its mechanism has not been concluded yet. Therefore, it is an important work to search andscreen the effective components of natural plants that have anti-fatigue effect and to explore theirmechanism. Methods: This was a 8-week, randomized, double-blind, placebo-controlled clinical trial. A total of 110subjects who passed physical examination were included according to the scheme design, and randomlydivided into a test group which was given KRG and a placebo control group. The calculation is carried outaccording to the standard of sub-high-intensity exercise test. Results: There was no adverse effect on safety index of subjects after taking red ginseng capsule. AfterKRG treatment, subjective strength grade is significant lower than placebo treatment. Blood lactic acidcontent is significantly get lower after trial in KRG group, and significant lower than placebo group. Creatine phosphokinase(CK) content is significantly get lower after trial in KRG group, and significantlower than placebo group. Conclusion: According to the criterion in the test scheme, the result shows that KRG is helpful onrelieving physical fatigue.

Wear Mechanisms of Al₂O<SUB>3f</SUB>/SiC<SUB>p</SUB> Reinforced Al Metal Matrix Composites under Dry and Lubricant Wear Conditions at Room Temperature

Yi Qi Wang,Yu Shi,Foisal Ahmand Mirza,Ali Md. Afsar,Jung Il Song(송정일) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.10

This study investigates the room temperature sliding wear mechanisms of Al₂O₃<SUB>f</SUB> and SiC<SUB>p</SUB> reinforced Al metal matrix composites (MMCs). The effects of fiber orientation and fiber to particle hybrid ratio on the wear behaviors at both the dry and lubricant conditions are discussed in details. The MMC specimens were fabricated by squeeze casting method with different hybrid ratios and fiber orientations. The tests were carried out by a pin-on-disk friction and wear tester at a constant sliding speed of 0.36 ㎧ (570 rpm) against a steel counter disk. The results of dry sliding tests showed that the F20P0 (unhybrid) MMCs with normal (N) orientation of fibers had better wear behaviors than those with planer-random (PR) orientation of fibers. However, for hybrid MMCs, the wear behavior was better for PR-orientation of fibers. On the contrary, the lubricant wear behaviors of F20P0 MMCs with PR-orientation of fibers were superior to those with N-orientation of fibers and the reverse lubricant wear behaviors were observed for hybrid MMCs. Finally, the scanning electron microscope (SEM) images of the wear surface and debris were used for investigating the modes of wear.

A Novel Method to Fabricate High Strength Nanofiber Filaments: Morphology, Crystalline Structure, and Thermal and Mechanical Properties

Yi-qi Wang,Xin Zhang,Zhi-juan Pan 한국섬유공학회 2018 Fibers and polymers Vol.19 No.6

Wet electrospinning is a simple and efficient method to manufacture continuous nanofiber filaments. However, polyacrylonitrile nanofiber filaments collected using a static water bath are limited for application in certain areas due to their low degree of alignment and breaking stress values. To improve these properties, a novel countercurrent flowing liquid bath collector was combined with a multi-needle electrospinning device. The morphologies, crystalline structures, thermal behaviors and mechanical properties of filaments fabricated under different countercurrent bath liquid motion conditions were investigated. In addition, the forces acting on the nanofibers in the bundling triangular zone under countercurrent liquid bath motion were analyzed. The results showed that the average nanofiber diameter of the filaments decreased with an increase in bath solution motion forces. The maximum alignment degree and breaking stress of the nanofibers were 85 % and 0.63 cN/dtex, respectively, achieved using a liquid flow rate of 80 ml/min and water inlet diameter of 6 mm. The alignment degree of the assembled nanofibers in the bundling triangular zone could be increased by 57 % when using a countercurrent flowing liquid compared with a static liquid bath.

Taguchi Method to Optimize Brazing Conditions of a Discharge Tube for Air-Conditioner

Yi Qi Wang,Won Kyung Joo,Yu Shi,Ali Md. Afsar,Jung-Il Song(송정일) 대한기계학회 2008 대한기계학회 춘추학술대회 Vol.2008 No.5

Brazing process was applied and optimized for joining the two dissimilar materials Oxygen-free high conductivity (OFHC) copper and ASTM A501 low carbon steel for a D-Tube using Ag-based (65%) alloy filler metal. Brazing joint clearance, length, temperature, and time were selected as design variables with the objective of producing the brazed joint having maximum bonding force and corresponding optimum brazing conditions. Taguchi method was used as a statistical design of experiment (DOE) technique for optimizing the brazing conditions in terms of tensile strength. L? (3⁴) orthogonal array design was used for conducting the experiments. The results verified that the brazing conditions developed in this study were the optimum ones for joining the OFHC copper and ASTM A501 low carbon steel.

Optimization of Brazing Conditions for OFHC Cu and ASTM A501 Low Carbon Steel by Taguchi Method

Wang, Yi Qi,Afsar, Ali Md.,Song, Jung-Il 한국정밀공학회 2009 International Journal of Precision Engineering and Vol.10 No.3

This paper concerns the optimization of brazing conditions for joining the two dissimilar materials Oxygen-free high conductivity (OFHC) copper and ASTM A501 low carbon steel usually used for an Oil-Separator of an air-conditioner using Ag-based(BAg) alloy as a brazing filler metal (BFM). A mixture of 70% $N_2$ and 30% $H_2$ gases was used to prevent oxidation of the joints during furnace brazing process. Brazing joint clearance, length, temperature, and time were selected as design parameters that have significant effect on the bonding strength of a brazed joint. Taguchi method was used as a statistical technique for design of experiment (DOE) in an attempt to optimize brazing conditions in terms of shear strength. $L_9\;(3^4)$ orthogonal array was designed for conducting the experiments. The relative influence of design parameters and their interaction on the response were also discussed. The experimental results verified that the brazing conditions predicted in this study by Taguchi method could produce the brazed joint between OFHC copper and ASTM A501 low carbon steel with maximum shear strength.

New method for rapidly estimating population densities of the concealed wood‐borer Monochamus alternatus (Coleoptera: Cerambycidae) in the field

Xiao‐Yi Wang,Zhong-qi Yang,Chun-Nan SITU,Jian WANG,Fu-Yong FU 한국곤충학회 2016 Entomological Research Vol.46 No.2

To rapidly estimate pine sawyer, Monochamus alternatus Hope, population densities in forests, the vertical distributions of M. alternatus oviposition sites and larvae on infested Masson pines (Pinus massoniana Lamb.) were studied. Results showed that the number of oviposition sites on sections of trunks between 0 and 2 m above ground was significantly greater than on sections of trunk above 2 m, and the vertical distribution had a significant logarithmic relationship with trunk height. The larval number of M. alternatus on dead infested trees had a significant difference among heights of trunks. Sections on trunks at 2–4 m usually contained the largest number of M. alternatus larvae, while the number of larvae on trunks above 10 m declined significantly, as well as in the 1 m section of trunk at the base. The vertical distribution of M. alternatus larvae on dead infested pines showed a distinct parabolic relationship with trunk height. The number of oviposition sites of M. alternatus on infested Masson pine trunks revealed a significant exponential relationship with the diameter at breast height (DBH) of trees. A significant positive linear relationship also was observed between M. alternatus larval number and DBH on the host pine trees, as well as between the numbers of larvae and oviposition sites on an individual tree. The total number of larvae in an infested tree could be calculated easily using an established equation, through counting the number of oviposition sites at 3–4 m of trunk aboveground. This study developed a practical method for rapid estimation of M. alternatus populations.