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Lu, Hong,Chen, Dong,Hu, Li-Ping,Zhou, Lian-Lian,Xu, Hui-Ying,Bai, Yong-Heng,Lin, Xiang-Yang Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
Molecular epidemiological studies have shown that gene polymorphisms of estrogen receptor alpha gene (ESR-${\alpha}$) are associated with breast cancer risk. However, previous results from many molecular studies have been inconsistent. In this study, we examined two polymorphisms (PvuII and XbaI RFLPs) of the ESR-${\alpha}$ gene in 542 breast cancer cases and 1,016 controls from China. Associations between the polymorphisms and breast cancer risk were calculated with an unconditional logistic regression model. Linkage disequilibrium and haplotypes were analyzed with the SHEsis software. In addition, we also performed a systematic meta-analysis of 24 published studies evaluating the association. No significant associations were found between the PvuII polymorphism and breast cancer risk. However, a significantly decreased risk of breast cancer was observed among carriers of the XbaI 'G' allele (age-adjusted OR = 0.80; 95% CI = 0.66- 0.97) compared with carriers of the 'A' allele. Haplotype analysis showed significantly decreased cancer risk for carriers of the 'CG' haplotype (OR = 0.79; 95% CI = 0.66- 0.96). In the systematic meta-analysis, the XbaI 'G' allele was associated with an overall significantly decreased risk of breast cancer (OR = 0.90, 95% CI = 0.82- 1.00). In addition, the PvuII 'C' allele showed a 0.96- fold decreased disease risk (95% CI = 0.92- 0.99). In subgroup analysis, an association between the PvuII 'C' and XbaI 'G' alleles and breast cancer risk was significant in Asians ('C' vs. 'T': OR = 0.93, 95% CI = 0.85- 1.00; 'G' vs. 'A': OR = 0.82, 95% CI = 0.68- 0.98), but not in Euro-Americans. Thus, our results provide evidence that ESR-${\alpha}$ polymorphisms are associated with susceptibility to breast cancer. These associations may largely depend on population characteristics and geographic location.
Shi, Yong Gang,Duan, Yu Lian,Chen, Jian Hua,Wu, Xiang Hua,Zhou, Ying,Zhang, Jun Feng Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.1
A bottom-modified (4-position) naphthalimide derivative 1 with 1,8-naphthyridine as binding site has been designed and synthesized. Compound 1 is the first 1,8-naphthyridine-modified naphthalimide-based sensor that can detect $Hg^{2+}$ selectively with respect to ratiometric fluorescent change and blue shift in organic aqueous solution. The Job's plot and FAB mass indicate that 1 formed a 1:1 complex with $Hg^{2+}$. A top-modified naphthalimide derivative 2 with 1,8-naphthyridin as binding site has also been synthesized for comparison.
Peng Nong,Yue Pan,Qinpeng Dong,Dafu Zeng,Mingzhao Xu,Xiang Wang,Jiaming Wang,Lian Deng,Xiuli Chen,Huanfu Zhou 대한금속·재료학회 2024 ELECTRONIC MATERIALS LETTERS Vol.20 No.1
NaNbO 3 -based lead-free ceramics are gaining widespread interest in recent years due to their environmental friendlinessand low density, which can meet the needs of future advanced pulse power electronics for low cost, miniaturization andintegration. However, a reversible phase transition of FE-AFE at room temperature for pure NaNbO 3 ceramic will producea large residual polarization, resulting in a low energy storage capacity. In this work, the ternary system (1- x )(0.92NaNbO 3 -0.08Bi(M g0.5 Ti 0.5 )O 3 )- x CaTiO 3 was designed by introducing the linear material CaTiO 3 doped into (0.92NaNbO 3 -0.08Bi(Mg 0.5 Ti 0.5 )O 3 ) ceramics to enhance the disorder of A/B sites in the system. The introduce of CaTiO 3 could optimizethe relaxation characteristics of the ceramics, refi ne the grain size to improve the breakdown fi eld strength( E b ), which enhancethe energy storage properties to W rec = 5.71 J/cm 3 and η = 85.7% at 475 kV/cm. Additionally, the 0.8(0.92NN-0.08BMT)-0.2CT ceramic achieves both temperature (20–160 °C) and frequency (5 Hz -120 Hz) stability, while also obtains excellentcharge/discharge performance( C D = 607.22 A/cm 2 , P D = 48.58 MW/cm 3 , t 0.9 = 28 ns), which indicates the great potentialapplication in pulsed power capacities.