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Highly stretchable polymer semiconductor films through the nanoconfinement effect
Xu, Jie,Wang, Sihong,Wang, Ging-Ji Nathan,Zhu, Chenxin,Luo, Shaochuan,Jin, Lihua,Gu, Xiaodan,Chen, Shucheng,Feig, Vivian R.,To, John W. F.,Rondeau-Gagné,, Simon,Park, Joonsuk,Schroeder, Bob C.,L American Association for the Advancement of Scienc 2017 Science Vol.355 No.6320
<P>Soft and conformable wearable electronics require stretchable semiconductors, but existing ones typically sacrifice charge transport mobility to achieve stretchability. We explore a concept based on the nanoconfinement of polymers to substantially improve the stretchability of polymer semiconductors, without affecting charge transport mobility. The increased polymer chain dynamics under nanoconfinement significantly reduces the modulus of the conjugated polymer and largely delays the onset of crack formation under strain. As a result, our fabricated semiconducting film can be stretched up to 100% strain without affecting mobility, retaining values comparable to that of amorphous silicon. The fully stretchable transistors exhibit high biaxial stretchability with minimal change in on current even when poked with a sharp object. We demonstrate a skinlike finger-wearable driver for a light-emitting diode.</P>
Changqing Wu,Feng Chen,James W. Rushing,Xi Wang,김현진,George Huang,Vivian Haley-Zitlin,Guoqing He 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.1
The medicinal herb feverfew [Tanacetum parthenium (L.) Schultz-Bip.] has long been used as a folk remedyfor the treatment of migraine and arthritis. Parthenolide, a sesquiterpene lactone, is considered to be the primary bioactivecompound in feverfew having anti-migraine, anti-tumor, and anti-inflammatory properties. In this study we determined, throughin vitrobioassays, the inhibitory activity of parthenolide and golden feverfew extract against two human breast cancer celllines (Hs605T and MCF-7) and one human cervical cancer cell line (SiHa). Feverfew ethanolic extract inhibited the growthof all three types of cancer cells with a half-effective concentration (EC50) of 1.5 mg/mL against Hs605T, 2.1 mg/mL againstMCF-7, and 0.6 mg/mL against SiHa. Among the tested constituents of feverfew (i.e., parthenolide, camphor, luteolin, andapigenin), parthenolide showed the highest inhibitory effect with an EC50 against Hs605T, MCF-7, and SiHa of 2.6 .g/mL,2.8 .g/mL, and 2.7 .g/mL, respectively. Interactions between parthenolide and flavonoids (apigenin and luteolin) in fever-few extract also were investigated to elucidate possible synergistic or antagonistic effects. The results revealed that apigeninand luteolin might have moderate to weak synergistic effects with parthenolide on the inhibition of cancer cell growth ofHs605T, MCF-7, and SiHa.