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Youn, Ui Joung,Nam, Kung-Woo,Kim, Hui-Seong,Choi, Goya,Jeong, Woo Seok,Lee, Mi Young,Chae, Sungwook Pharmaceutical Society of Japan 2011 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.34 No.6
<P>Tumor necrosis factor α (TNF-α), which is a primary cytokine responsible for inflammatory responses in skin, induces the synthesis of matrix metalloproteinase-9 (MMP-9), which causes skin aging. The protective effects of 3-deoxysappanchalcone against TNF-α-induced damage was investigated using human skin keratinocytes. The results showed that 3-deoxysappanchalcone inhibited MMP-9 expression at the protein and mRNA level, by blocking the activation of activator protein-1 (AP-1) and nuclear factor kappa B (NF-κB). Taken together, the inhibitory activity of 3-deoxysappanchalcone on MMP-9 expression and production in TNF-α-treated cells was found to be mediated by the suppression of AP-1 and NF-κB activation.</P>
Joung Youn, Ui,Lee, Jun-Ho,Lee, Yoo Jin,Nam, Joo Won,Bae, Hyunsu,Seo, Eun-Kyoung WILEY-VCH Verlag 2010 CHEMISTRY AND BIODIVERSITY Vol.7 No.9
<P>Four known alkyl 4-hydroxybenzoates, i.e., methyl 4-hydroxybenzoate (1), ethyl 4-hydroxybenzoate (2), propyl 4-hydroxybenzoate (3), and butyl 4-hydroxybenzoate (4), were isolated from the seeds of Nelumbo nucifera Gaertner (Nymphaeaceae) for the first time. The structures of the isolates were identified by 1D- and 2D-NMR spectroscopy and comparison with published values. The compounds were evaluated for their effects on the 5-HT-stimulated inward current (I<SUB>5-HT</SUB>) mediated by the human 5-HT<SUB>3</SUB>A receptors expressed in Xenopus oocytes. Compounds 1 and 2 enhanced the I<SUB>5-HT</SUB>, but 4 reduced it. These results indicate that 4 is an inhibitor of the 5-HT<SUB>3</SUB>A receptors expressed in Xenopus oocytes.</P> <B>Graphic Abstract</B> <P> <img src='wiley_img_2010/16121872-2010-7-9-CBDV200900393-content.gif' alt='wiley_img_2010/16121872-2010-7-9-CBDV200900393-content'> </P>
Ui Joung Youn,구본석,김경희,Chulgyu Ha,정인찬 대한약침학회 2018 Journal of pharmacopuncture Vol.21 No.2
Contents of compounds in Rehmanniae Radix change depending on the number of steaming and drying and the drying method. In this study, as an impregnation method for dried Rehmanniae Radix, takju impregnation and cheongju impregnation were carried out and steaming and drying were repeated for 9 times. The changes of 5-HMF and catalpol contents were analyzed according to the number of repetition times to investigate which stage of steaming and drying is preferable. Also, total nitrogen, crude fat, ash, and crude fiber were measured to analyze changes in general components. 5-HMF was not detected in dried Rehmanniae Radix. As a result of repetitive steaming and drying, the content of 5-HMF increased only slightly from 1 to 4-times steaming and drying but increased significantly from 5-times. The catalpol in dried Rehmanniae Radix was not detected after 5 times of steaming and drying. Sucrose, maltose, and glucose were included in dried Rehmanniae Radix before steaming and drying. However, after the process in both Takju impregnation and Cheongju impregnation, galactose and fructose tended to decrease after production and sucrose and glucose tended to decrease after the increase. In this study condition, 6-times and more steaming and drying were appropriate process which met the content criteria (not less than 0.1%) of the Korean Pharmacopoeia (8th edition) for 5-HMF, an index component for quality control of Rehmanniae Radix Preparata.
Youn, Ui Joung,Park, Eun-Jung,Kondratyuk, Tamara P.,Sang-Ngern, Mayuramas,Wall, Marisa M.,Wei, Yanzhang,Pezzuto, John M.,Chang, Leng Chee American Chemical Society and American Society of 2016 Journal of natural products Vol.79 No.6
<P>A new fatty acid ester disaccharide, 2-O-(beta-D-glucopyranosyl)-1-O-(2E,4Z,7Z)-deca-2,4,7-trienoyl-beta-D-glucopyranose (1), a new ascorbic acid derivative, 2-caffeoyl-3-ketohexulofuranosonic acid gamma-lactone (2), and a new iridoid glycoside, 10-dimethoxyfermiloside (3), were isolated along with 13 known compounds (4-16) from fermented noni fruit juice (Morinda citrifolia). The structures of the new compounds, together with 4 and 5, were determined by 1D and 2D NMR experiments, as well as comparison with published values. Compounds 2 and 7 showed moderate inhibitory activities in a TNF-alpha-induced NF-kappa B assay, and compounds 4 and 6 exhibited considerable quinone reductase-1 (QR1) inducing effects.</P>
Youn, Ui Joung,Sripisut, Tawanun,Park, Eun-Jung,Kondratyuk, Tamara P.,Fatima, Nighat,Simmons, Charles J.,Wall, Marisa M.,Sun, Dianqing,Pezzuto, John M.,Chang, Leng Chee Elsevier 2015 Bioorganic & medicinal chemistry letters Vol.25 No.21
<P><B>Abstract</B></P> <P>Chemical investigation of an endophytic fungus <I>Chaetomium globosum</I> isolated from leaves of <I>Wikstroemia uva-ursi</I> led to the isolation of two new azaphilones, chaetoviridins J and K (<B>1</B> and <B>3</B>), along with five known derivatives (<B>2</B> and <B>4</B>–<B>7</B>). The structures of azaphilones were determined by NMR, X-ray diffraction, Mosher’s method, and CD analysis. The isolated compounds were evaluated for their cancer chemopreventive-potential based on their abilities to inhibit tumor necrosis factor alpha (TNF-α)-induced nuclear factor-kappa B (NF-κB). Compounds <B>4</B>, <B>5</B>, <B>7</B>, and synthetic <B>8</B> and <B>9</B> inhibit nitric oxide (NO) production with IC<SUB>50</SUB> values in the range of 0.3–5.8μM. Compounds <B>4</B>, <B>5</B>, and <B>9</B> also displayed (TNF-α)-induced NF-κB activity with IC<SUB>50</SUB> values in the range of 0.9–5.1μM.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Identification of Antiadipogenic Constituents of the Rhizomes of Anemarrhena asphodeloides
Joung Youn, Ui,Ye Seul, Lee,Ha Na, Jung,Jun, Lee,Joo Won, Nam,Yoo Jin, Lee,Eun Sook, Hwang,Je Hyun, Lee,Dong Ho, Lee,Sam Sik, Kang,Eun Kyoung, Seo 이화여자대학교 약학연구소 2010 藥學硏究論文集 Vol.- No.20
Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 microM.