http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Joung Youn, Ui,Lee, Jun-Ho,Lee, Yoo Jin,Nam, Joo Won,Bae, Hyunsu,Seo, Eun-Kyoung WILEY-VCH Verlag 2010 CHEMISTRY AND BIODIVERSITY Vol.7 No.9
<P>Four known alkyl 4-hydroxybenzoates, i.e., methyl 4-hydroxybenzoate (1), ethyl 4-hydroxybenzoate (2), propyl 4-hydroxybenzoate (3), and butyl 4-hydroxybenzoate (4), were isolated from the seeds of Nelumbo nucifera Gaertner (Nymphaeaceae) for the first time. The structures of the isolates were identified by 1D- and 2D-NMR spectroscopy and comparison with published values. The compounds were evaluated for their effects on the 5-HT-stimulated inward current (I<SUB>5-HT</SUB>) mediated by the human 5-HT<SUB>3</SUB>A receptors expressed in Xenopus oocytes. Compounds 1 and 2 enhanced the I<SUB>5-HT</SUB>, but 4 reduced it. These results indicate that 4 is an inhibitor of the 5-HT<SUB>3</SUB>A receptors expressed in Xenopus oocytes.</P> <B>Graphic Abstract</B> <P> <img src='wiley_img_2010/16121872-2010-7-9-CBDV200900393-content.gif' alt='wiley_img_2010/16121872-2010-7-9-CBDV200900393-content'> </P>
Youn, Ui Joung,Nam, Kung-Woo,Kim, Hui-Seong,Choi, Goya,Jeong, Woo Seok,Lee, Mi Young,Chae, Sungwook Pharmaceutical Society of Japan 2011 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.34 No.6
<P>Tumor necrosis factor α (TNF-α), which is a primary cytokine responsible for inflammatory responses in skin, induces the synthesis of matrix metalloproteinase-9 (MMP-9), which causes skin aging. The protective effects of 3-deoxysappanchalcone against TNF-α-induced damage was investigated using human skin keratinocytes. The results showed that 3-deoxysappanchalcone inhibited MMP-9 expression at the protein and mRNA level, by blocking the activation of activator protein-1 (AP-1) and nuclear factor kappa B (NF-κB). Taken together, the inhibitory activity of 3-deoxysappanchalcone on MMP-9 expression and production in TNF-α-treated cells was found to be mediated by the suppression of AP-1 and NF-κB activation.</P>
Identification of new pyrrole alkaloids from the fruits of Lycium chinense
Ui Joung Youn,서은경,Joo Yun Lee,길윤서,한아름,Chong Hak Chae,Shi Yong Ryu 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.3
Three new minor pyrrole alkaloids, 3-[2-formyl- 5-(hydroxymethyl)-1H-pyrrol-1-yl]pentanedioic acid (1), (2R)-[2-formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]-1- methoxy-1-oxobutanoic acid (2), and methyl (2R)-[2-formyl- 5-(methoxymethyl)-1H-pyrrol-1-yl]-4-methylpentanoate (3) were isolated from the fruits of Lycium chinense Miller (Solanaceae), along with the known compound, methyl (2R)-[2-formyl-5-(methoxymethyl)- 1H-pyrrol-1-yl]-3-(phenyl)propanoate (4). The structures of 1–4 were elucidated by analysis of their 1Dand 2D-NMR and HRMS data. The absolute configurations of 2–4, possessing a stereogenic center in each structure, were determined by comparison of their experimental electronic circular dichroism (ECD) with those of calculated ECD values.
Youn, Ui Joung,Sripisut, Tawanun,Park, Eun-Jung,Kondratyuk, Tamara P.,Fatima, Nighat,Simmons, Charles J.,Wall, Marisa M.,Sun, Dianqing,Pezzuto, John M.,Chang, Leng Chee Elsevier 2015 Bioorganic & medicinal chemistry letters Vol.25 No.21
<P><B>Abstract</B></P> <P>Chemical investigation of an endophytic fungus <I>Chaetomium globosum</I> isolated from leaves of <I>Wikstroemia uva-ursi</I> led to the isolation of two new azaphilones, chaetoviridins J and K (<B>1</B> and <B>3</B>), along with five known derivatives (<B>2</B> and <B>4</B>–<B>7</B>). The structures of azaphilones were determined by NMR, X-ray diffraction, Mosher’s method, and CD analysis. The isolated compounds were evaluated for their cancer chemopreventive-potential based on their abilities to inhibit tumor necrosis factor alpha (TNF-α)-induced nuclear factor-kappa B (NF-κB). Compounds <B>4</B>, <B>5</B>, <B>7</B>, and synthetic <B>8</B> and <B>9</B> inhibit nitric oxide (NO) production with IC<SUB>50</SUB> values in the range of 0.3–5.8μM. Compounds <B>4</B>, <B>5</B>, and <B>9</B> also displayed (TNF-α)-induced NF-κB activity with IC<SUB>50</SUB> values in the range of 0.9–5.1μM.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Identification of Antiadipogenic Constituents of the Rhizomes of Anemarrhena asphodeloides
Joung Youn, Ui,Ye Seul, Lee,Ha Na, Jung,Jun, Lee,Joo Won, Nam,Yoo Jin, Lee,Eun Sook, Hwang,Je Hyun, Lee,Dong Ho, Lee,Sam Sik, Kang,Eun Kyoung, Seo 이화여자대학교 약학연구소 2010 藥學硏究論文集 Vol.- No.20
Three new phenolic compounds, (E)-4'-demethyl-6-methyleucomin (1), anemarcoumarin A (2), and anemarchalconyn (3), were isolated from an ethyl acetate extract of the rhizomes of Anemarrhena asphodeloides, together with seven known compounds (4-10). The structures of the new compounds (1-3) were determined on the basis of spectroscopic data interpretation. Compound 3 exhibited a potent inhibitory effect against the differentiation of preadipocyte 3T3-L1 cells with an IC50 value of 5.3 microM.