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( Sunmin Yim ),( Jung Yup Kim ),( Jae Yun Lim ),( Ju-yeon Choi ),( Han-saem Kim ),( Jung-in Kim ),( Jung Min ),( Joon Hong Min ),( Young Jun Choi ),( Jae Hui Nam ),( Ga-young Lee ),( Won-serk Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Background: A low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet (QSND) laser has been used for treatment of pigmented disorders. However, the photobiological mechanism of the low-fluence 1064-nm QSND laser is not yet fully understood. Objectives: To evaluate inhibitory effects of the low-fluence 1064-nm QSND laser on the melanogenesis and assess whether increasing the number of passes of low-fluence the 1064-nm QSND laser has positive correlation with improvements of the pigmentation. Methods: The skins of six Hair Moprpholoy-2 melanin-possessing hairless mice were treated with ultraviolet B radiation followed by 0, 2, 4, 6 passes the low-fluence 1064-nm QSND laser. Pigmentation changes of skins were evaluated with spectrophotometry and pigmentation-related protein expressions. Additionally, biopsy specimens were obtained to figure out the difference of melanin particles. Results: The low-fluence 1064-nm QSND laser improved the lightness of the skin in comparison to the control skin. Biopsy specimens showed decreased amounts of melanin particles. In the western blot of the specimen, expressions of MITF and tyrosinase were reduced. Conclusion: The low-fluence 1064-nm QSND laser has effects on the melanogenesis which change expressions of the pigmentation-related proteins. Moreover, the more passes of the laser toning can bring the more progress on the skin pigmentation.
Sunmin Park,Won Park,Shin-Hyung Park,Joo Young Kim,Jin Hee Kim,Haeyoung Kim,Yeon-Sil Kim,Won Kyung Cho,Won Sup Yoon,Dae Sik Yang 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.3
Objective: This study aimed to evaluate the oncologic outcomes according to disease burden in uterine cervical cancer patients with metachronous distant metastases. Methods: Between 2005 and 2015, 163 patients with metachronous distant metastases from uterine cervical cancer after receiving a definitive therapy were evaluated at seven institutions in Korea. Low metastatic burden was defined as less than 5 metastatic sites, whereas high metastatic burden was others. Each metastasis site was divided based on the lymph node (LN) and organs affected. The overall survival (OS) and progression-free survival (PFS) were assessed. Cox proportional hazards models, including other clinical variables, were used to evaluate the survival outcomes. Results: The median follow-up duration was 22.2 months (range: 0.3–174.8 months). Para- aortic LNs (56.4%), lungs (26.4%), supraclavicular LNs (18.4%), and peritoneum (13.5%) were found to be the common metastasis sites. Among 37 patients with a single metastasis, 17 (45.9%) had LN metastases and 20 (54.1%) had organ metastases. The 1- and 2-year OS rates were 73.9% and 55.0%, respectively, whereas the PFS rates were 67.2% and 42.9%, respectively. SCC Ag after recurrence and high metastatic burden were significant factors affecting the OS (p=0.004 and p<0.001, respectively). Distant organ recurrence, short disease-free interval (≤2 years), and high metastatic burden were unfavorable factors for PFS (p=0.003, p=0.011, and p=0.002, respectively). Conclusion: A favorable oncologic outcome can be expected by performing salvage treatments in selected patients with a long disease-free interval, low metastatic burden, and/ or lymphatic-only metastasis.
( Jung Yup Kim ),( Sunmin Yim ),( Jae Yun Lim ),( Ju-yeon Choi ),( Han-saem Kim ),( Jung-in Kim ),( Jung Min ),( Joon Hong Min ),( Young Jun Choi ),( Jae Hui Nam ),( Ga-young Lee ),( Won-serk Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Background: Scars can affect patients, leading to emotional complications. Various laser technologies including fractional laser, Q-Switched Nd:YAG laser, and pulsed dye laser have been tried to revise the scar. Up to now, there has been no reliable study to evaluate an effect of picosecond Nd:YAG laser for reducing scars. Objectives: This retrospective clinical study was performed to investigate the beneficial effect of picosecond Nd:YAG laser in treatment for hypertrophic scars. Methods: A retrospective review was conducted on patients treated with picosecond Nd:YAG laser for the purpose of scar improvement. Twenty-seven patients with hypertrophic scars were included in this study. The vancouver scar scale (VSS), global assessment score (GAS), and participant’s subjective satisfaction were used to determine the effect of scar improvement. All side effects were recorded to assess the safety of the modality. Results: Mean age of patients was 33.4±15.2 years old and male-to-female ratio was 2:3. Mean total treatment session was 3.4±1.3 and mean total duration of treatment was 13±7.3 weeks. Average VSS score was remarkably decreased after treatment. Average GAS and participant’s satisfaction indicated fair cosmetic improvement. No significant side effects were observed during follow-up. Conclusion: Picosecond Nd:YAG laser may be considered as an effective and safe optional modality for the treatment of scar.
김화영(Hwayoung Kim),김형민(Hyungmin Kim),송민수(Minsu Song),안지훈(Jihun An),김강현(Ganghyun Kim),김선민(Sunmin Kim),김찬현(Chanhyun Kim),박성우(Seoungwoo Park),이준우(Junu Lee),이준기(Joonki Rhee),임재혁(Jaehyuk Im),정승수(Seungsu Jeo 한국추진공학회 2022 한국추진공학회 학술대회논문집 Vol.2022 No.5
본 논문은 경기대학교 KURBC 팀이 설계한 모듈형 신기전K22에 대한 설계과정과 그 근거를 서술하였다. 로켓의 임무는 ‘로켓 발사 후 낙하 시 낙하산 사출 및 안전한 회수’이다. 목표 고도는 400m, 연료는 질산칼륨-소르비톨(KNSB)이다. 낙하산 사출 방법은 동체와 낙하산이 안전하게 보호되는 용수철 사출을 선택했다. 본 팀은 이번 대회에서 CFRP 카본으로 로켓의 동체를 만들고, 내부를 모듈로 구성함으로써 차별점을 두었다. 또한 RF 장거리 통신 기술을 이용하여 발사 전후의 데이터를 체계적으로 기록하여 후속 연구에 참고할 예정이다. This paper describes the design process and basis for the modular Shinkijeon-K22 designed by the KURBC team of Kyonggi University. The rockets mission is devising a method for parachute injection and safe recovery when falling after launching the rocket. The target altitude is 400 m and the fuel is potassium nitrate-solvitol (KNSB). The spring injection method was used for the parachute injection, in which the fuselage and parachute are safely protected. We made a difference by making the rockets fuselage with CFRP carbon and configuring the interior as a module. In addition, RF long-distance communication technology will be used to systematically record data before and after launch and refer it to subsequent studies.
Kim, Sunmin,Park, SangYoun American Society for Biochemistry and Molecular Bi 2013 The Journal of biological chemistry Vol.288 No.38
<P>In <I>Escherichia coli</I>, three cysteine desulfurases (IscS, SufS, and CsdA) initiate the delivery of sulfur for various biological processes such as the biogenesis of Fe-S clusters. The sulfur generated as persulfide on a cysteine residue of cysteine desulfurases is further transferred to Fe-S scaffolds (<I>e.g.</I> IscU) or to intermediate cysteine-containing sulfur acceptors (<I>e.g.</I> TusA, SufE, and CsdE) prior to its utilization. Here, we report the structures of CsdA and the CsdA-CsdE complex, which provide insight into the sulfur transfer mediated by the <I>trans</I>-persulfuration reaction. Analysis of the structures indicates that the conformational flexibility of the active cysteine loop in CsdE is essential for accepting the persulfide from the cysteine of CsdA. Additionally, CsdA and CsdE invoke a different binding mode than those of previously reported cysteine desulfurase (IscS) and sulfur acceptors (TusA and IscU). Moreover, the conservation of interaction-mediating residues between CsdA/SufS and CsdE/SufE further suggests that the SufS-SufE interface likely resembles that of CsdA and CsdE.</P>
[P464] A case of methylphenidate induced livedo reticularis on the extremities
( Sunmin Yim ),( Junghwa Yang ),( Yun Ho Lee ),( Jung Yup Kim ),( Jae Yun Lim ),( Ju-yeon Choi ),( Han-saem Kim ),( Joon Hong Min ),( Young Jun Choi ),( Jae-hui Nam ),( Ga-young Lee ),( Won-serk Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Methylphenidate is the drug of choice for patients with Attention deficit hyperactivity disorders (ADHD). It acts as a dopamine and norepinephrine reuptake inhibitor, resulting in a prolongation of dopamine receptor effects. Most common side effects associated with its use include nervousness, insomnia, and dizziness. Although patients on methylphenidate frequently complain of dermatologic symptoms such as hyperhidrosis, hypersensitivity, pruritus, and hair loss, cases of peripheral vasculopathy without systemic involvement have rarely been documented. We describe the case of an 11 year-old male with ADHD who has been on methylphenidate for two years. On his initial visit to this hospital, he complained of regional erythematous reticular patches on both hands, lower legs, and both feet. The patient denied having systemic symptoms such as fever, malaise and arthralgia. Subsequent blood tests and rheumatologic labs were unremarkable. After discontinuing methylphenidate for two weeks, the patient`s symptoms were relieved. This case shows that the latent reaction of methylphenidate can induce symptoms of peripheral vasculopathy, such as livedo reticularis and the Raynaud phenomenon.
( Sunmin Yim ),( Junghwa Yang ),( Yun Ho Lee ),( Jung Yup Kim ),( Jae Yun Lim ),( Ju-yeon Choi ),( Han-saem Kim ),( Joon Hong Min ),( Young Jun Choi ),( Jae-hui Nam ),( Ga-young Lee ),( Won-serk Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Grid fractional radiofrequency (GFR), fractional radiofrequency microneedle (FRM) and high intensity focused ultrasound (HIFU) have each specific mechanism for skin rejuvenation. Nasolabial fold wrinkles can be treated by applying consecutive sessions of three modalities. Objectives: To evaluate the clinical efficacy of the combined treatment of nasolabial fold wrinkles in Asians. Methods: This was a prospective study that enrolled twenty subjects with moderate nasolabial fold wrinkles. Subjects visited the clinic every four weeks for a total of three treatment sessions. Subjects received a combination therapy of GFR, FRM, and HIFU. Evaluation included medical photographs and satisfaction questionnaires. Two dermatologists evaluated the clinical photographs using the modified Fitzpatrick wrinkle scale (mFWS). Results: A total of eighteen subjects were assessed. The median age was 56.5 (Range 49-64). mFWS showed an improved score of 1.0 (IQR 0.5-1.375) at twenty weeks compared to a baseline score of 1.5 (IQR 1-1.875). (p <0.005) Six subjects (33 %) reported more than moderate improvement at twentieth week. There were no long-term complications associated with the treatment. Conclusion: This study was the first of its kind to use a triple combined therapy for the treatment of skin wrinkles. The results demonstrated the efficacy and safety of the combination therapy on nasolabial fold wrinkles.