2형 당뇨 환자에 있어서 C형 간염의 유병률에 관한 연구

김구영,서광섭,유광렬,임병욱,채선애,강남훈,김창훈,권영우,김희수,류성태,이정환,박성우,오웅식,김정한 중앙대학교 의과대학 의과학연구소 2003 中央醫大誌 Vol.28 No.1

Background: We have doubt about the truth that Type 2 DM is associated with chronic hepatitis C infection. The aim of our study was to prove a close relationship between chronic HCV infection and type 2 DM in korean patients. Methods: We reviewed the out-patient's medical records of 466 patients with type 2 DM who visit the Sung-ae hospital from March 2000 to August 2001. Diabetic patients were analyzed for the following variables: age, sex, waist circumference, weight, waist/hip ratio, using of self monitoring of blood glucose, method of therapy, duration of disease, experience of previous transfusion, major surgical procedure, accompanied disease, liver function tests (LFT), HbA1 c. We ruled out patients with liver cirrhosis. Results: Hepatitis C virus infection was observed more frequently in patient with Type 2 DM. Of 466 Type 2 DM patients, 13 patients were infected with Hepatitis C virus (2.79%). Compared with mean prevalence of Korean population (1.3~1.6%), it's value is very high. the other hand, 21 patients were infected with Hepatitis B virus (4.5%). Such results are similar to mean prevalence of the general public (4~5%). Conclusions: Prevalence of hepatitis C was closely associated in korean patients with type 2 DM. And an increased prevalence is independent of cirrhosis.

The level of urinary aflatoxin M1 in Korean adults

Yong-Dae Kim1, Hyojin Kwon, Sun-In Moon, Sang-Yong Eom, Jung-Duk Park, Byung-Sun Choi, Seok-Joon Sohn, Young-Seoub Hong, Ho Kim, Ho-Jang Kwon, Ji-Ae Lim, Hae-Jung Yoon, Gwang-Jin Kim, Heon Kim 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.3

Competitive ELISA methods were used to measure the level of aflatoxin M1 (AFM1) from urine in 1008 Korean adults. Subjects were selected by random sampling in all areas of Korea, except Cheju-do. The recovery rate of AFM1 using this method was 105% (73-124%). The geometric mean of urinary AFM1 in all subjects was 3.43 pg/mL (3.67 ng/g creatinine). The level of AFM1 in males was statistically higher, compared with female subjects. However, the levels of AFM1 did not differ according to age. Subjects in Chungbuk-do showed the highest urinary AFM1 concentration, whereas subjects in Kyeongnam-do showed the lowest concentration. Assuming an excretion rate of 5%, this AFM1 excretion corresponds to approximately 0.1 microgram/day in Korean adults.

저해요인 분석에 기반한 클래스 응집도 척도

김성애,최완규,이성주 조선대학교 전자정보통신연구소 2001 電子情報通信硏究所論文誌 Vol.4 No.1

Highly cohesive classes define only a data factor(instance variable) whose all methods(or operations) refer to, or have the maximum connection among elements in a class. Therefore, an increase in the number of the data factors, and the operations to obstruct the maximum connection among elements in a class are the main factors to decrease the class cohesion. In this paper, we propose a new measure, called CCM(Class Cohesion Measure), which can measure the class cohesion more consistently with our intuition on the basis of factors to decrease it. We use the reference graph in order to find the decreasing factors of the class cohesion, and measure the class cohesion on the basizs of analysis of the domain reference graph. CCM can provide more upgraded measures than the existing measures through comparing it with the measures of existing cohesion.

확장된 객체 지향적 설계방법론에 관한 고찰

金晟愛,李聖周,李潤培 조선대학교 기초과학연구소 1990 自然科學硏究 Vol.13 No.1

The object-oriented approach views a system as a set of objects, each object having a set of well defined operations, and a transformation function that transforms the objects by performing operations on the objects. The Current object-oriented design methodology proposed by Booch is strictly object-oriented, as it concentrates on identifying the objects and the operations on the objects and places little emphasis on the transformation function. This approach is acceptable for smaller systems, but may not be suitable for Complex problems, where the transformation function may be fairly complex. For such systems the design methodology should explicitly adress the design of the transformation function. In this paper we have incorporated a top-down, refinement technique with the object-oriented design methodology in an effort to alleviate this limitation of the methodology.

PCR 기법을 이용한 한국재래산양 β-casein 유전자의 특성

김지애,류승희,유성란,이준헌,서길웅,김선균,상병찬 충남대학교 농업과학연구소 2002 농업과학연구 Vol.29 No.2

본 연구는 한국 재래 산양 112두와 유산양인 Saanen종 7두의 혈액으로부터 genomic DNA를 추출하고, PCR-RFLP 방법에 의해 β-casein 유전자의 특성을 분석하여 한국재래산양의 효율적인 유전자원의 보전 및 개량을 위한 기초 자료로 제공하고자 실시하였다. 한국재래산양의 genomic DNA로부터 PCR기법을 이용하여 β-casein의 유전자좌를 증폭한 결과 각각 481bp 크기의 단편이 양호하게 증폭되었음을 확인하였다. β-casein 유전자좌의 증폭산물에 대한 Bal Ⅰ의 제한효소를 처리한 결과, β-casein AB형은 481bp, 284bp 및 197bp의 단편을, 그리고 BB형은 284BP와 197BP의 단편을 한국재래산양과 유산양인 Saanen 종에서 확인 할 수 있었다, 유전자형 빈도에 있어서는 한국재래산양에서 β-casein AB 및 BB의 빈도는 각각 6.25 및 93.75%이었고, 유산양인 Saanen 종은 각각 57.14 및 42.86%이었다. 유전자빈도에 있어서는 한국재래산양의 β-casein A 및 B의 빈도가 각각 0.031 및 0.969이었고, Saanen 종에서는 각각 0.286 및 0.714의 빈도를 보였다 한국재래산양의 β-casein 유전자의 염기서열과 이미 보고되어 있는 goat의 염기서열(GeneBank accession Number M90556)간에는 총 11개의 염기서열에 차이를 나타내어 97.71%의 상동성을 보였다, 따라서 한국재래산양의 β-casein 유전자의 다형성과 염기서열 분석에 의한 분자유전학적 특성의 규명은 한국재래산양의 유전자원의 보전 및 개량을 위한 기초 및 응용 자료로 이용될 수 있을 것으로 생각된다. This study was performed to provide the basic data for preservation and improvement of genetic resources according to finding genetic construction obtained from analysis of genetic characteristics of β-casein gene in Korean Native goat and Saanen using the PCR-RFLP. This study confirmed the amplified products of 481bp fragments obtained from the amplification of β-casein loci by PCR. The β-casein AB genotype showed 481, 284 and 197bp, and β-casein BB genotype showed 284 and 197bp fragments in Korean Native goat and Saanen. The frequencies of β-casein genotype in Korean Native goat were 6.25 and 93.75% for AA and AB and the frequencies of β-casein genotype in Saanen were 57.14 and 42.86% for AA and AB types. The frequencies of β-casein A and B alleles were 0.031 and 0.969 in Korean Native goat and the frequencies of β-casein A and B alleles are 0.286 and 0.714 in Saanen, respectively. The nucleotide sequence of β-casein gene of Korean Native goat was 97.71% higher homology with 11 nucleotide sequences difference of that of goat reported in GeneBank (M90556). Therefore, this study of molecular genetic characteristics by the analysis of genetic polymorphism and sequencing for β-casein gene should be used as basic and applying data for preservation and improvement of genetic resources in Korean Native goat breeding.

노인에서 처음으로 발생한 간질의 원인

김제,이애영,정진상,김재문 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

Seizures in the geriatric population are uncommon. They are more commonly associated with underlying brain lesions than seizures of other generations. We investigated type and cause in 44 patients, who experienced seizures firstly over 60 years old during last 6 years. Intracranial lesions on CT and/or MRI were also in vestigated in each type of seizure. Generalized tonic-clonic seizure was more common seizure type (26 patients, 59%) than focal seizures (18, 41%). The causes of seizures were detectable in 77% of patients. Previous stroke was the most frequent cause of seizures (18 of 44 patients, 41%), particularly in thrombotic infarcts (14 patients). Brain tumors (primary 3; metastatic 2), previous trauma history (2), alcohol withdrawal (4), neurocysticercosis (1), and viral meningoencephalitis (2) were followed. In 10 patients (23%). no causative factor was identified. Brain lesions were visualized in 72% of focal-onset seizures and in 42% of generalized seizures on CTs and/or MRIs. We concluded that generalized tonic-clonic type is common type of seizure and causes of seizures were frequently detected in first onset seizure patients over 60 years old.

간호대학생의 임상실습에 대한 인식유형 : Q방법론적 접근

김명애,김효은,남승희 성인간호학회 2001 성인간호학회지 Vol.13 No.2

The purpose of this study is to explore perception types and to understand the nature education by using the Q methodology A Q sample was developed through a review of the literature and descriptions about nursing students' experience in clinical practice. Thirty-six statements made up the finalized Q sample. The P sample consisted of 33 third grade nursing students in K university. Q statements were written on separate cards and were given to the 33 subjects to sort according to degree of agreement or disagreement. The Q-sorts by each subject were coded and analysed with the Quanl PC program. A a result, three major perception types, namely, 'alienation of ideal and reality'<type 1>, 'active participation'<type 2>, and 'perception of identifying the nature of the three types. this limitation of ability'<type 3> were identified. By identifying the nature of the three types, this study suggests efficient strategies for developing clinical educational programs according to the perception types of nursing students Clinical education would thereby be more valuable.

개질 결합재의 노화 특성이 아스팔트 콘크리트의 강도특성에 미치는 영향

김광수,안경애,김성운,이상범,이순제 강원대학교 석재복합신소재제품연구센터 2001 석재연 논문집 Vol.6 No.-

아스팔트의 노화 진행 과정의 특성과 아스팔트 혼합물의 노화 특성과의 관계에 대한 국내에서의 연구는 거의 전무한 실정이다. 따라서 본 연구에서는 결합재인 아스팔트의 노화가 아스팔트 혼합물의 특성에 미치는 영향을 분석하였다. 결합재로 사용된 폴리머 3종류와 골재 두 종류, 두 가지 입도, 두 종류의 아스팔트를 사용하여 32종류의 혼합물을 제조하고, 이를 다시 노화 전, 단기노화, 장기노화 처리하였다. 각각의 개질ㆍ비개질 아스팔트혼합물의 노화 과정의 특성을 분석하기 위하여 회복탄성계수실험(MR)과 간접인장강도실험(ITS)을 수행하였고, 추출ㆍ회수 후 바인더 특성시험(침입도, 동점도, 절대점도, GPC)을 수행하였다. 이를 다시 SAS를 이용하여 통계 분석하였다. 혼합물 시험에서 노화가 진행되어 감에 따라 회복탄성계수 및 간접인장강도는 크게 증가했다. 그리고 밀입도가 갭입도보다 강도 특성에서 크게 나타났고, 폴리머간의 비교에서 송진을 개빌한 바인더를 사용한 혼합물의 특성이 가장 우수하게 나타나 상온에서 가장 효과적인 개질재임을 알 수 있었다. 바인더 시험에서 골재 종류가 노화시 물성에 심각한 요인임을 알 수 있었고, 입도는 점도변화에 큰 영향을 미치는 것으로 나타났으며 폴리머는 아스팔트 자체의 노화에 영향을 미치지 않는 인자임을 확인할 수 있었다. 또한 GPC를 이용한 LMS 측정으로 추출ㆍ회수없이도 바인더 물성을 어느 정도 예측 할 수 있는 가능성을 나타냈다. 본 연구 결과 아스팔트 혼합물의 노화특성은 골재 종류, 입도, 개질재의 종류, 바인더의 종류 등의 다양한 요인에 의해 영향을 받는 상태에서 바인더의 특성 변화만으로 혼합물의 강도 특성 변화를 추정하는데는 어려움이 있음을 알 수 있었다. Asphalt concrete is a mixed product of asphalt binder and aggregates. Asphalt binder characteristics in asphalt mixture are changed due to aging of binder. Since asphalt mixture becomes stiffer and brittle due to age hardening of binder, mechanical properties of asphalt concrete are also a function of binder characteristics. However, the correlation of mixture mechanical property with asphalt (binder) property is not well known. This study dealt with evaluation of physical properties of asphalt binder, including polymer modified asphalt (PMA), and mechanical properties of asphalt mixture. The measured physical properties included absolute viscosity, kinematic viscosity, penetration, and LMS (large molecular size). The mechanical property included resilient modulus, indirect tensile strength and stiffness index. Statistical analyses were carried out to find out the factor(s) having a significant effect on change of physical and/or mechanical properties of asphalt mixture due to aging. A relatively high correlation was found from each physical property with stiffness index.

원발성 진챙성 실어증 1례

이애영,오상근,김제,김재문 대한신경과학회 1998 대한신경과학회지 Vol.16 No.2

양모 폴리에스테르 혼방직물의 역학적특성과 태에 관한 연구

김경애,김성희 우석대학교 자원개발연구소 1996 자원개발연구소논문집 Vol.1 No.-

To determine the change of the mechanical properties of the wool/polyester blend fabrics in promotion to blend ratio and weave type. 16 mechanical properties and hand value were measured on 5 blend fabrics by KES-F system. Statistical analysis was performed using T-test, ANOVA. The results were as follow : (1) There was significant difference in tensile, bending, shearing, surface, compression according to the blend ratio. (2) According to the weave there was significant difference in tensile bending surface compression in the wool/polyester blended fabrics. 3. There was significant difference in stiffness according to the blend ratio. (4) According to the weave there was significant difference in anti-drape stiffness crispness fullness in the polyester blended fabrics.