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Akt is involved in the inhibition of cell proliferation by EGF
Soung Hoo Jeon,정우정,Jae-Young Cho,이기호,최강열 생화학분자생물학회 2007 Experimental and molecular medicine Vol.39 No.4
Axin is a negative regulator of the Wnt/β-catenin path-way and is involved in the regulation of axis formation and proliferation. Involvement of Axin in the regulation of other signaling pathways is poorly understood. In growth regulation by Axin in L929 fibroblasts stimu-lated by EGF. Akt activity was increased by EGF treat-ment and Ras activation, respectively. Both the EGF- and Ras-induced Akt activations were abolished by Axin induction, as revealed by both Western blot and imunocytochemical analyses. The proliferation and Akt activation induced by EGF were decreased by Axin induction, and the efects of EGF were abolished by treatment of an Akt-specific inhibitor. Therefore, Axin by blocking Akt activation.
Effect of platelet-rich plasma on dental stem cells derived from human impacted third molars.
Lee, Ui-Lyong,Jeon, Soung Hoo,Park, Joo-Young,Choung, Pill-Hoon Future Medicine 2011 Regenerative medicine Vol.6 No.1
<P>Platelet-rich plasma (PRP) is fabricated from autologous blood and extensively used to promote soft and hard tissue healing. In the dental field, autologous PRP is widely used combined with dental implant installation and bone graft. This study will evaluate the biologic effect of PRP on the proliferation and the differentiation of human dental stem cells, and find the key cytokines inducing these effects to estimate the clinical feasibility of PRP for dental tissue engineering.</P>
Park, Joo-Young,Jeon, Ho-Jin,Kim, Tae Yun,Lee, Kyeong-Yeoll,Park, Kyoungsook,Lee, Eui Seok,Choi, Je-Min,Park, Chung-Gyu,Jeon, Soung-Hoo Future Medicine 2013 Regenerative medicine Vol.8 No.4
<P>Human dental mesenchymal stem cells (hDMSCs) have been isolated from extracted human teeth and proven to have different proliferation and differentiation abilities among the subtypes. Despite increasing interest in the clinical use of hDMSCs, a well-defined specific marker has been absent for these stem cells. In this study, a comparative analysis with known mesenchymal stem cell surface markers such as STRO-1, CD90, CD146, CD34 and TfR (CD71) was performed.</P>
REE, Han-Il,JEON, Soung-Hoo,LEE, In-Yong INSTITUTE OF TROPICAL MEDICINE YONSEI UNIVERSITY 1995 YONSEI REPORTS ON TROPICAL MEDICINE Vol.26 No.1
As it was reported that hydramethylnon was excreted in the feces of bait-fed German cockroaches before being killed and coprophagous uptake by other cockroaches resulted in high mortality, we observed how long such a secondary killing effect lasts and how effectively kill them in the laboratory condition. A group of 30 1st instar nymphs was exposed to the feces excreted by 25 male bait-fed cochroaches for 10 days and the mortality rate was counted, and new group was re-introduced with 10 days intervals until the mortality dropped to the control level. The mortality rate was 81.1% in average 57.6% (943 dead/1,636 exposed) of the cumulative mortality rate during 180 days of the study period. When 25 4th-5th instar nymphs were exposed to hydramethylnon instead of 25 males, the mortality rate was 79.5%, 37.8%, 17.9% in average of 1st-6th tests, 7th-13th tests and 14th-17th tests, respectively, showing 48.9% (799 dead/1,635 exposed) of the cumulative rate during 180 days of the study period.
Egg Mortality of German Cockroaches Exposed to Fenitrothion MC Bait and Hydramethylnon Bait
Ree, Han-Il,Jeon, Soung-Hoo 한국곤충학회 1998 Entomological Research Vol.28 No.3
바퀴(Blattella germanica)는 난 발육이 완성될 때까지 난협을 복부말단에 달고 다닌다 최근 널리 사용되고 있는 fenitrothion MC bait와 hydramethylnon bait섭취 후 죽은 암컷의 난협내 알의 부화율을 75% RH의 높은 습도하에서 관찰하여 다음과 같은 결과를 얻었다. Fenitrothion MC bait을 처리한 군에서는 68%의 난협부화율(17/25)과 64.4%의 알부화율(520/807)을 얻었고, hydramethylnon bait 처리군에서는 60% (15/25) 난협부화율과 59.3% (499/842)의 난부화율을 보였는데 이들간의 통계적 유의성은 없었다. 두부를 제거한 대조군의 경우는 84% (21/25)의 난협부화율과 87.2% (728/835)의 난부화율을 보여 상기 살충제 처리군과는 유의성이 있었다(P< 0.05). 45% 습도하의 대조군(두부절단)에서는 28%와 36.7%의 난협 및 난부화율을 각각 나타냈고 20% 습도하의 대조군에서는 전혀 부화하지 않았다. 난협의 발육 정도 또는 난협의 어미로부터의 탈락 여부와 난협 부화율간에는 어떤 연관성도 보이지 않았다. The viability of the oothecae (eggs) of Blattella germanica females which were killed by ingesting fenitrothion MC bait and hydramethylnon bait was studied under the high humidity condition (75 % RH). In case of the females treated with fenitrothion MC bait, 17 oothecae out of 25 (68%) and 520 eggs out of 807 (64.4%) were hatched during the period of 4-24 days after treatment. In case of the females treated with hydramethylnon bait, 15 oothecae out of 25 (60%) and 499 eggs out of 842 (59.3%) were hatched during the period of 1-28 days after treatment. In the control group (decapitated females), 21 oothecae out of 25 (84%) and 728 eggs out of 835 (87.2%) were hatched during the period of 1-24 days after decapitation, which was significantly different from those of the eggs of the females treated with both fenitrothion MC bait and hydramethylnon bait (P<0.05). Neither the degree of maturity of oothecae, nor detachment/attachment of oothecae from/to female abdomens were correlated to the hatching (viability) of the oothecae.
Structure of the Female Genitalia of Korean Cetoniidae(Coleoptera , Scarabaeoidea)
Kim, Jin Ill,Jeon, Soung Hoo 고려대학교 한국곤충연구소 1991 昆蟲硏究誌 Vol.17 No.1
The external and internal female genitalia were described on 5 species of Korea, which were Gnorimus subopacus, Glycyphana fulvistemma, Trichius succinctus, Charitovalgus fumosus and Nipponovalgus angusticollis belonging to Cetoniidae. The internal female genitalia of the other species had the tubular type, with separate bursa copulatrix. but G. subopacus had the saccular type, without separate bursa copulatrix. The external female genitalia of the other species had differentiated several sclerotized plates (coxites, paraprocts, proctigers). but G. subopacus had a pair sclerotized plates in the body wall of the vagina and well-developed sclerotized structure lying inner cavity of the vagina characteristically.
Comparative study of LHX8 expression between odontoma and dental tissue‐derived stem cells
Kim, Ji‐,Youn,Jeon, Soung Hoo,Park, Joo‐,Young,Suh, Je‐,Duck,Choung, Pill‐,Hoon Blackwell Publishing Ltd 2011 Journal of oral pathology & medicine Vol.40 No.3
<P> <I>J Oral Pathol Med</I> (2011) <B>40</B>: 250–256</P><P><B>Background: </B> <I>LHX8</I> (LIM‐homeobox gene 8) is known as an important regulating factor in tooth morphogenesis. Odontoma is a mixed odontogenic tumor where epithelium and mesenchyme differentiated together, resulting in anomalous tooth structures. In this study, gene and protein expressions of LHX8 were analyzed in human odontoma‐derived mesenchymal cells (HODC) compared to adult dental mesenchymal stem cells (aDSC), as well as morphological and histological characteristics of odontoma were analyzed.</P><P><B>Methods: </B> aDSCs were isolated from normal teeth, and HODCs were isolated from surgically removed odontoma mass. Morphological and histological evaluations were performed to compare between compound odontomas and normal premolars. RT‐PCR and real‐time PCR were performed to identify <I>LHX8</I> mRNA expression in the HODCs and aDSCs. LHX8 protein expression levels were observed by immunoblotting and immunofluorescent staining.</P><P><B>Results: </B> The compound odontoma was composed of multiple tooth‐like structures, which contained disorganized but recognizable enamel matrix, dentin, pulp, and cementum. <I>LHX8</I> mRNA and LHX8 protein expressions were all higher in HODCs compared to those in aDSCs examined by RT‐PCR, immunoblot, and immunofluorescent staining. Especially, real‐time PCR showed 2.77‐fold higher <I>LHX8</I> expression in HODCs than in normal periodontal ligament stem cells (PDLSCs), while alveolar bone marrow stem cells (ABMSCs) expressed 0.12‐fold <I>LHX8</I> than PDLSCs.</P><P><B>Conclusions: </B> Based on these observations, LHX8 might play an important role in odontoma formation. This is the first report regarding the comparison of LHX8 expression between HODC and normal aDSCs and its overexpression in human samples. The specific mechanism of LHX8 in odontoma morphogenesis awaits further study.</P>