Association of<i>CYP2A6</i>polymorphisms with S-1 plus docetaxel therapy outcomes in metastatic gastric cancer

Kong, Sun-Young,Lim, Hyeong-Seok,Nam, Byung-Ho,Kook, Myeong-Cherl,Kim, Young-Woo,Won Ryu, Keun,Lee, Jun Ho,Choi, Il Ju,Lee, Jin Soo,Park, Young-Iee,Kim, Noe Kyeong,Park, Sook Ryun Future Medicine 2009 Pharmacogenomics Vol.10 No.7

<P>AIMS: S-1, an oral fluoropyrimidine, contains tegafur, which is converted to 5-fluorouracil mainly by CYP2A6. We evaluated the association between CYP2A6 polymorphisms and treatment outcome in metastatic gastric cancer patients treated with S-1 plus docetaxel. MATERIALS & METHODS: Chemonaive patients received S-1 40 mg/m(2) twice daily on days 1-14 and docetaxel 35 mg/m(2) on days 1 and 8 of a 3-week cycle. We analyzed the wild-type (W) allele (CYP2A6*1) and four variant (V) alleles that abolish or reduce enzyme activity (CYP2A6*4, *7, *9 and *10). A total of 50 patients were enrolled. RESULTS: The genotype frequencies were as follows: W/W (n=14, 28%), W/V (n=26, 52%) and V/V (n=0, 20%). Patients having fewer variant alleles had significantly better response rates (W/W vs W/V vs V/V=79 vs 65 vs 30%; p=0.04) and median progression-free survival (W/W vs W/V vs V/V=8.1 vs 6.9 vs 3.1 months; p=0.0009). CONCLUSION: Our findings showed that the CYP2A6 genotype correlated with the treatment efficacy of S-1-based chemotherapy in previously untreated metastatic gastric cancer patients.</P>

REMARKS ON FINITE ELEMENT METHODS FOR CORNER SINGULARITIES USING SIF

Kim, Seokchan,Kong, Soo Ryun The Honam Mathematical Society 2016 호남수학학술지 Vol.38 No.3

In [15] they introduced a new finite element method for accurate numerical solutions of Poisson equations with corner singularities, which is useful for the problem with known stress intensity factor. They consider the Poisson equations with homogeneous Dirichlet boundary condition, compute the finite element solution using standard FEM and use the extraction formula to compute the stress intensity factor, then they pose a PDE with a regular solution by imposing the nonhomogeneous boundary condition using the computed stress intensity factor, which converges with optimal speed. From the solution we could get accurate solution just by adding the singular part. This approach works for the case when we have the accurate stress intensity factor. In this paper we consider Poisson equations with mixed boundary conditions and show the method depends the accrucy of the stress intensity factor by considering two algorithms.

REMARKS ON FINITE ELEMENT METHODS FOR CORNER SINGULARITIES USING SIF

( Seokchan Kim ),( Soo Ryun Kong ) 호남수학회 2016 호남수학학술지 Vol.38 No.3

In [15] they introduced a new finite element method for accurate numerical solutions of Poisson equations with corner singularities, which is useful for the problem with known stress intensity factor. They consider the Poisson equations with homogeneous Dirichlet boundary condition, compute the finite element solution using standard FEM and use the extraction formula to compute the stress intensity factor, then they pose a PDE with a regular solution by imposing the nonhomogeneous boundary condition using the computed stress intensity factor, which converges with optimal speed. From the solution we could get accurate solution just by adding the singular part. This approach works for the case when we have the accurate stress intensity factor. In this paper we consider Poisson equations with mixed boundary conditions and show the method depends the accrucy of the stress intensity factor by considering two algorithms.

Mouse에 對한 人蔘의 抗痙攣作用

李惠子,具姬洙,孔化淳,申萬鍊 中央醫學社 1970 中央醫學 Vol.18 No.1

It has been reported that the convulsion induced by cocain was suppressed by Panax Ginseng and the onset of convulsion by metrazol and picrotoxin on frogs was definitely prolonged in large doses of Panax Ginseng. In this study, it was attempted to investigate the anticonvulsant effect of Panax Ginseng extract on the cardiazol convulsion of mice. And the anticonvulsant effect of Panax Ginseng ,extract was compared with pheny tion and reserpine on the cardiazol convulsion. The following results were obtained. 1. The onset of the cardiazol convulsion on mice was definitely prolonged by pretreatment with Panax Ginseng extract for both 7 days and 15 days. 2. The prolongation of the onset of the cardiazol convulsion by Panax Ginseng extract was almost same as phenytoin 1mg/kg. 3. The onset of the cardiazol convulsion on mice was inclined to shorten by the pretreatment with reserpine.

A Comparative Genome-Wide Analysis of GATA Transcription Factors in Fungi

Park, Jong-Sun,Kim, Hyo-Jeong,Kim, Soon-Ok,Kong, Sung-Hyung,Park, Jae-Jin,Kim, Se-Ryun,Han, Hyea-Young,Park, Bong-Soo,Jung, Kyong-Yong,Lee, Yong-Hwan Korea Genome Organization 2006 Genomics & informatics Vol.4 No.4

GATA transcription factors are widespread eukaryotic regulators whose DNA-binding domain is a class IV zinc finger motif in the form $CX_{2}CX_{17-20}CX_{2}C$followed by a basic region. In fungi, they act as transcriptional activators or repressors in several different processes, ranging from nitrogen source utilization to mating-type switching. Using an in-house bioinformatics portal system, we surveyed 50 fungal and 9 out-group genomes and identified 396 putative fungal GATA transcription factors. The proportion of GATA transcription factors within a genome varied among taxonomic lineages. Subsequent analyses of phylogenetic relationships among the fungal GATA transcription factors, as well as a study of their domain architecture and gene structure, demonstrated high degrees of conservation in type IVa and type IVb zinc finger motifs and the existence of distinctive clusters at least at the level of subphylum. The SFH1 subgroup with a 20-residue loop was newly identified, in addition to six well-defined subgroups in the subphylum Pezizomycotina. Furthermore, a novel GATA motif with a 2f-residue loop ($CX_{2}CX_{21}CX_{2}C$, designated 'zinc finger type IVc') was discovered within the phylum Basidiomycota. Our results suggest that fungal GATA factors might have undergone multiple distinct modes of evolution resulting in diversified cellular modulation in fungi.

Effect of a Probiotic Strain, Enterococcus faecium, on the Immune Responses of Olive Flounder (Paralichthys olivaceus)

( Yu Ri Kim ),( Eun Young Kim ),( Sun Young Choi ),( Muhammad Tofazzal Hossain ),( Ryun Kyoung Oh ),( Won Seok Heo ),( Jong Min Lee ),( Young Chai Cho ),( In Soo Kong ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.4

The present study was aimed to investigate the effect of a probiotic, Enterococcus faecium, on the immune responses against infection with the marine fish pathogen Lactococcus garvieae in olive flounder (Paralichthys olivaceus). The immune responses were assessed by lysozyme activity, complement activity, protease activity, and expression of proinflammatory cytokines by RT-PCR. The lysozyme and complement activities were increased between 9 to 15 and 9 to 13 days, respectively, and antiprotease activity was slightly elevated after 5 days of probiotic treatment. The TNF-α and IL-1β expressions were observed from kidney and spleen. The results of this study reveal that E. faecium induces immune-responsible materials and protects olive flounder from lactococcosis.

EDTA와 붕산 혼합용출제를 이용한 중금속으로 오염된 토양의 처리에 관한 연구(I): 납

이종열,김용수,권영호,공성호,박신영,이창환,성혜련,Lee Jong-Yeol,Kim Yong-Soo,Kwon Young-Ho,Kong Sung-Ho,Park Shin-Young,Lee Chang-Hwan,Sung Hae-Ryun 한국지하수토양환경학회 2004 지하수토양환경 Vol.9 No.4

납으로 오염된 토양을 정화하는 방법인 토양수세기법에 가장 효율적인 용출제를 선정하기 위해서 여러 가지 유기산의 납 제거효율을 측정한 결과 0.01M의 EDTA 주입 시 납 제거효율은 $69.4\%$로 같은 농도의 다른 유기산과 비교해서 가장 높은 효율을 보였다. 또한 0.01M의 EDTA에 0.1M의 여러 가지 무기산을 혼합한 후 납 제거효율을 비교한 결과 EDTA와 붕산 혼합용출제가 pH5에서 $68.8\%$로 가장 높았다. EDTA와 붕산 혼합용출제의 경우 0.01M의 EDTA에 붕산의 주입농도를 0.1M에서 0.4M로 증가시킬 경우 납의 탈착/제거율은 $68\%$에서 $45\%$로 감소하였다. 그러나 0.1M의 붕산에 EDTA의 주입농도를 0.01M에서 0.04M로 증가시킬 경우 투수율은 $6.98{\times}10^{-4}cm/sec$에서 $5.99{\times}10^{-4}cm/sec$로 감소하였다. 이처럼 EDTA는 납의 탈착/제거율을 증가시키는 반면 투수율를 감소시키는 단점이 있다. 그러나 0.03M EDTA에 0.1M 붕산을 첨가한 경우 EDTA만을 주입한 경우와 비교해서 투수율이 $4.41{\times}10^{-4}cm/sec$에서 $6.26{\times}10^{-4}cm/sec$로 약 $30\%$ 증가되었다. 실제 중금속 오염토양에서 납의 제거효율은 납의 탈착/제거율과 오염토양 내 용출제의 투수율의 함수로 정의할 수 있으며, 최적의 [EDTA]/[붕산] 몰비는 [0.01M]/[0.1M]로 조사되었다. To choose a organic acid and in-organic acid composite which is the most effective in soil-flushing process cleaning lead-contaminated sites, lead removal rates were investigated in the experiments with some organic acids; 0.01M of EDTA showed the highest lead-extraction rate ($69.4\%$) compared to the other organic acids. Furthermore, the lead removal rates were measured with 0.01M of EDIA and 0.1M of in-organic acid ; a EDTA and boric acid composite showed the highest lead-extraction rate ($68.8\%$) at pH5 compared to the other composites. As the concentration of boric acid was increased from 0.1M to 0.4M in a 0.01M of EDTA and boric acid composite, lead removal rate was decreased from $68\%\;to\;45\%$. But as the concentration of EDTA was increased from 0.01M to 0.04M in a EDTA and 0.1M of boric acid composite, permeability was decreased from $6.98{\times}10^{-4}cm/sec$ (0.01M of EDTA) to $5.99{\times}10^{-4}cm/sec$ (0.04M of EDTA). However, permeability was increased from $4.41{\times}10^{-4}cm/sec$ (0.03M of EDTA) to $6.26{\times}10^{-4}cm/sec$ (0.03M of EDTA and 0.1M of boric acid composite). indicating EDTA could increase lead dissolution/extraction rate and decrease permeability. In this system, lead remediation rate is the function of lead dissolution rate from soils and permeability of the composite into soils, and the optimized [EDTA]/[Boric acid] ratio is [0.01M]/[0.1M].

생체모방기반 분산형 무선자원할당 기법 연구

김영재(Kim Young Jae),정지영(Jung Ji Young),김운하(Kim Un Ha),공으뜸(Kong Eu Tteum),이찬재(Lee Chan Jae),최현호(Choi Hyun HO),최증원(Choi Jeung Won),노봉수(Roh Bong Soo),서난솔(Seo Nan Sol),이정륜(Lee Jung Ryun) 한국통신학회 2015 한국통신학회 학술대회논문집 Vol.2015 No.1