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허홍욱,이송진,최금자,허만규 부산대학교 환경문제연구소 2004 環境硏究報 Vol.22 No.-
Plant Population Structure of three areas in Young-do of Busan
Song, Byung-Cheol,Cui, Xiu Ji,Shin, Jung Woo,Park, Neung Hwa,Cho, Yoo-Kyung,Song, Hyun Joo,Hyun, Soyoung,Jeong, Seung Uk,Choi, Eun Kwang,Kim, Heung Up S. Karger AG 2010 Intervirology Vol.53 No.4
<P><I>Objective:</I> In vitro studies showed that mutations in the basal core promoter (BCP) or precore (PC) region restore the replication inefficiency of the lamivudine-resistant mutant. The aim of this study was to clarify the effect of molecular characteristics on the antiviral response to adefovir in patients with lamivudine-resistant chronic hepatitis B (CHB). <I>Methods:</I> Sixty-six lamivudine-resistant patients who were treated with adefovir monotherapy were studied. Sequences of BCP, PC region and reverse transcriptase were determined before adefovir therapy. In patients with virologic breakthrough, reverse transcriptase sequencing was performed. <I>Results:</I> The cumulative probabilities of virologic response were 23.3, 46, 52.7 and 59.5% at years 1, 2, 3 and 4, respectively. PC mutation, the absence of compensatory mutations (rtL80I/V or rtV173L), and a decrease in serum hepatitis B virus (HBV) DNA by 3 log or greater at 6 months were independent predictors of virologic response. The cumulative probabilities of virologic breakthrough were 0, 12.9, 30.7 and 44.5% at years 1, 2, 3 and 4, respectively. BCP mutation and a less than 3 log decrease in serum HBV DNA at 6 months were 2 independent risk factors for virologic breakthrough. <I>Conclusion:</I> Response to adefovir depends on mutation patterns in the BCP, PC region and reverse transcriptase, and on-treatment decreases in serum HBV DNA in lamivudine-resistant CHB patients.</P><P>Copyright © 2010 S. Karger AG, Basel</P>
Song, Byung-Cheol,Cui, Xiu Ji,Cho, Yoo-Kyung,Choi, Eun Kwang,Hyun, Soyoung,Song, Hyun Joo,Kim, Heung Up Elsevier 2009 HEPATOLOGY RESEARCH Vol.39 No.11
<P>In endemic areas of hepatitis B virus (HBV) infection, lamivudine-induced hepatitis B e-antigen (HBeAg) loss is not durable. We developed a scoring system to predict the relapse after lamivudine-induced HBeAg loss.</P>
Cui, Hui Song,Hong, A Ram,Kim, June-Bum,Yu, Joo Hyang,Cho, Yoon Soo,Joo, So Young,Seo, Cheong Hoon MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.1
<P>Extracorporeal shock wave therapy (ESWT) considerably improves the appearance and symptoms of post-burn hypertrophic scars (HTS). However, the mechanism underlying the observed beneficial effects is not well understood. The objective of this study was to elucidate the mechanism underlying changes in cellular and molecular biology that is induced by ESWT of fibroblasts derived from scar tissue (HTSFs). We cultured primary dermal fibroblasts derived from human HTS and exposed these cells to 1000 impulses of 0.03, 0.1, and 0.3 mJ/mm<SUP>2</SUP>. At 24 h and 72 h after treatment, real-time PCR and western blotting were used to detect mRNA and protein expression, respectively, and cell viability and mobility were assessed. While HTSF viability was not affected, migration was decreased by ESWT. Transforming growth factor beta 1 (TGF-β1) expression was reduced and alpha smooth muscle actin (α-SMA), collagen-I, fibronectin, and twist-1 were reduced significantly after ESWT. Expression of E-cadherin was increased, while that of N-cadherin was reduced. Expression of inhibitor of DNA binding 1 and 2 was increased. In conclusion, suppressed epithelial-mesenchymal transition might be responsible for the anti-scarring effect of ESWT, and has potential as a therapeutic target in the management of post-burn scars.</P>
Wound Healing Potential of Low Temperature Plasma in Human Primary Epidermal Keratinocytes
Hui Song Cui,Yoon Soo Cho,So Young Joo,Chin Hee Mun,Cheong Hoon Seo,June-Bum Kim 한국조직공학과 재생의학회 2019 조직공학과 재생의학 Vol.16 No.6
BACKGROUND: Low temperature plasma (LTP) was recently shown to be potentially useful for biomedical applications such as bleeding cessation, cancer treatment, and wound healing, among others. Keratinocytes are a major cell type that migrates directionally into the wound bed, and their proliferation leads to complete wound closure during the cutaneous repair/regeneration process. However, the beneficial effects of LTP on human keratinocytes have not been well studied. Therefore, we investigated migration, growth factor production, and cytokine secretion in primary human keratinocytes after LTP treatment. METHODS: Primary cultured keratinocytes were obtained from human skin biopsies. Cell viability was measured with the EZ-Cytox cell viability assay, cell migration was evaluated by an in vitro wound healing assay, gene expression was analyzed by quantitative real-time polymerase chain reaction, and protein expression was measured by enzyme-linked immunosorbent assays and western blotting after LTP treatment. RESULTS: Cell migration, the secretion of several cytokines, and gene and protein levels of angiogenic growth factors increased in LTP-treated human keratinocytes without associated cell toxicity. LTP treatment also significantly induced the expression of hypoxia inducible factor-1a (HIF-1a), an upstream regulator of angiogenesis. Further, the inhibition of HIF- 1a expression blocked the production of angiogenic growth factors induced by LTP in human keratinocytes. CONCLUSION: Our results suggest that LTP treatment is an effective approach to modulate wound healing-related molecules in epidermal keratinocytes and might promote angiogenesis, leading to improved wound healing.
최방(Cui Fang)송재훈(Song Jaehoon) 한국경영사학회 2021 經營史學 Vol.97 No.-
기업에 있어서 인센티브제도는 주로 종업원의 내재된 잠재력을 자극하고, 지적 능력을 유발하며, 적극성 창조성 등을 유발한다. 중국은 지난 1978년 경제개방 이후 비록 민간기업 분야에서 다년간의 발전 과정을 통해 끊임없이 경험과 교훈을 축적하여 기업의 경쟁력과 규모를 갖추게 되었지만 글로벌화에 따른 경제사회 발전으로 기업 간 경쟁이 치열해 지면서 일부 민영기업의 생존이 큰 도전에 직면해 있다. 갈수록 치열해지는 시장 경쟁은 결국 인재들의 경쟁이고, 기업 발전의 핵심은 얼마나 많은 인재를 확보하느냐가 관건이다. 그런 의미에서 본 연구는 1978년 이래 중국의 민영기업의 인적자원 관리측면에서 인센티브의 중요성과 관련 대책 및 분석을 주로 다루었다. 본 연구에 의하면 중국 민영기업의 경영자는 반드시 효율적인 인센티브제도의 도입을 통해 기업의 현존하는 문제를 해결할 수 있도록 해야 한다는 점이다. 특히 민간기업 분야에서 동기부여 메커니즘을 보다 많이 연구하고 끊임없이 혁신하며, 유연한 사고틀의 견지를 통해 외부로부터 성공 사례를 깊이 있게 분석하여 목표를 실현해야 한다는 점이다. 이러한 차원에서 본 연구에서는 중국의 민영기업들이 종업원들의 동기부여를 위한 보다 적합하고 효과적인 메커니즘을 수립해 보았으며 민영기업의 발전을 위한 방안을 제시해 보았다. 특히 중국 민영기업의 종업원 인센티브 시스템 구축에 있어서 다양한 아이디어를 활용하고, 체계적이고 이성적인 제도를 통해 격려주체가 객체와 상호작용하는 방식으로 기업이 이상을 현실로 바꾸는 방안이 필요하다고 보여진다. Motivation is mainly to stimulate the inner potential of human beings, triggering human intelligence, mobilize human enthusiasm and creativity. While our private enterprises have been developing over the years in China, they have been accumulating experience and lessons to make their businesses take shape. However, with the continuous development of the economy and society, the competition among enterprises has become increasingly fierce, and the survival of private enterprises are facing huge challenges. Increasingly fierce competition in the market is ultimately the competition of talent, the core of enterprise development is the talent pool, the good management in human resources mainly rely on the incentive mechanism and methods, only through an effective and perfect incentive mechanism can play the potential of talent, reserve better resources for the enterprise. This paper mainly discusses the importance of incentive mechanisms in enterprise human resource management and the related countermeasure analysis. The managers of private enterprises in China should learn to effectively draw on research methods, target to solve their practical problems and strive to make breakthroughs on the theoretical side. On the way of studying and constructing the incentive mechanism of private enterprises in China, we should constantly innovate and divergent thinking, and deeply analyze the success cases of different enterprises from the surface to the inside, to achieve the research objectives. And sum up a set of an effective mechanisms for employee incentives, which suitable for China’s private enterprises, to promote the vigorous development of private enterprises in China. This paper also discusses the construction of the incentive mechanism for employees in Chinese private enterprises. Attempt to motivate the employees in the company from different ideas and different perspectives. Employee incentive mechanism is a way to reflect the interaction between incentive subject and incentive object through the systematic and rational system, it is the connection that will transfer enterprise’s ideas into reality.