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RISS 인기검색어
- 검색키워드
- 저자 : ( Shukhrat Khudayberdiyevich Ziyadullaev ) (검색결과 2 건)
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( Shukhrat Khudayberdiyevich Ziyadullaev ),( Nazira Musaevna Khaitova ),( Tamara Uktamovna Aripova ),( Musa M Khaydarov ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Important gene-candidate asthma is a gene of enzymes biotransformation xenobiotics - GSTp1, expressing almost exclusively in lung tissue. This gene is located in locus 11q13, for which repeatedly show adhesion to atopic symptoms. The purpose of the study was to establish the distribution of allele and genotype frequencies of polymorphic variant gene GSTp1 patients allergic asthma and to establish a “negative” combination leading to the development of the disease in the Uzbek population. The distribution of allele and genotype frequencies of polymorphic variant gene GSTp1 in patients with asthma. The diagnosis was verifi ed in accordance with the diagnostic criteria GINA-2006. Material for investigation, DNA samples of patients with asthma and healthy Uzbek people. Analysis of the polymorphic variant gene GSTp1 carried out by PCR of DNA synthesis on a thermocycler and RfiP analysis using primers Forward - 5`-GTA GTT TGC CCA AGG TCA AG-3 ‘Reverse - 5’-AGC CAC CTG AGG GGT AAG -3 ‘and subsequent detection of the restriction fragments by electrophoresis in a 6% polyacrylamide gel. In the analysis of allele frequencies Ile-105/Val-105 polymorphism gene GSTp1 found that Ile105 allele in patients allergic asthma is more common than in the group of healthy individuals (80% opposite 65%). The study of polymorphism genotypes shows that in patients with allergic asthma frequency of the homozygous variant Ile105Ile gene signifi cantly higher than the control group of healthy individuals (62% opposite 30%). Thus, the results of molecular genetic studies have demonstrated the importance of a polymorphic variant of the gene GSTp1, the formation of the genetic structure of the predisposition to allergic asthma in the Uzbek population. The fi ndings suggest that markers of increased risk of allergic asthma in people of Uzbek ethnicity are genotype GSTp1-Ile105Ile and allele GSTp1-Ile105.
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( Shukhrat Khudayberdiyevich Ziyadullaev ),( Nazira Musaevna Khaitova ),( Tamara Uktamovna Aripova ),( Nematilla Ravshanovich Aralov ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Changes in the immune status of patients with asthma in adolescence, manifested deficiency of interferon`s, create preconditions for frequent acute respiratory viral infections and the development of their background exacerbations of the disease. The purpose of the study was to examine the preventive effi cacy of N-methylglucamine salt of acridone acetic acid (cycloferon) in complex treatment of patients with asthma according to the results of observation during 12 months. In the department of Allergology Samarkand City were examined 57 adolescents and youths with asthma aged 12 to 21 years treated drug cycloferon in a complex of basic therapy. Verifi cation of the diagnosis of asthma was conducted according to the international classifi cation and in accordance with the diagnostic criteria - GINA. Prophylactic effi cacy was assessed by clinical characteristics not earlier than one year after the course immunomodulatory therapy. All studies were performed with the informed consent of subjects and in accordance with the ethical standards. In the study of clinical data of patients treated cycloferon, with their raw data revealed a signifi cant decrease in the frequency of exacerbations during the year. Reduction of exacerbations of asthma during the year in patients receiving treatment course with the drug cycloferon, averaged 3 exacerbations per year, whereas prior to the current treatment of exacerbations of asthma recorded an average of 7 times. The average duration of an exacerbation in patients treated cycloferon, averaging 3,6 days has signifi cant differences from the index, calculated prior to the application of immunomodulators in treatment of asthma in adolescents. Thus, the courses of nonspecifi c immunotherapy drug cycloferon in asthmatic adolescents 2 times reduces the incidence of asthma exacerbations. By the absence adverse effects and improve clinical indicators cycloferon can be recommended in the complex treatment of patients with asthma in adolescents.
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