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- 저자 : ( Musa M Khaydarov ) (검색결과 1 건)
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( Shukhrat Khudayberdiyevich Ziyadullaev ),( Nazira Musaevna Khaitova ),( Tamara Uktamovna Aripova ),( Musa M Khaydarov ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Important gene-candidate asthma is a gene of enzymes biotransformation xenobiotics - GSTp1, expressing almost exclusively in lung tissue. This gene is located in locus 11q13, for which repeatedly show adhesion to atopic symptoms. The purpose of the study was to establish the distribution of allele and genotype frequencies of polymorphic variant gene GSTp1 patients allergic asthma and to establish a “negative” combination leading to the development of the disease in the Uzbek population. The distribution of allele and genotype frequencies of polymorphic variant gene GSTp1 in patients with asthma. The diagnosis was verifi ed in accordance with the diagnostic criteria GINA-2006. Material for investigation, DNA samples of patients with asthma and healthy Uzbek people. Analysis of the polymorphic variant gene GSTp1 carried out by PCR of DNA synthesis on a thermocycler and RfiP analysis using primers Forward - 5`-GTA GTT TGC CCA AGG TCA AG-3 ‘Reverse - 5’-AGC CAC CTG AGG GGT AAG -3 ‘and subsequent detection of the restriction fragments by electrophoresis in a 6% polyacrylamide gel. In the analysis of allele frequencies Ile-105/Val-105 polymorphism gene GSTp1 found that Ile105 allele in patients allergic asthma is more common than in the group of healthy individuals (80% opposite 65%). The study of polymorphism genotypes shows that in patients with allergic asthma frequency of the homozygous variant Ile105Ile gene signifi cantly higher than the control group of healthy individuals (62% opposite 30%). Thus, the results of molecular genetic studies have demonstrated the importance of a polymorphic variant of the gene GSTp1, the formation of the genetic structure of the predisposition to allergic asthma in the Uzbek population. The fi ndings suggest that markers of increased risk of allergic asthma in people of Uzbek ethnicity are genotype GSTp1-Ile105Ile and allele GSTp1-Ile105.
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