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- 저자 : ( Nematilla Ravshanovich Aralov ) (검색결과 1 건)
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( Shukhrat Khudayberdiyevich Ziyadullaev ),( Nazira Musaevna Khaitova ),( Tamara Uktamovna Aripova ),( Nematilla Ravshanovich Aralov ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Changes in the immune status of patients with asthma in adolescence, manifested deficiency of interferon`s, create preconditions for frequent acute respiratory viral infections and the development of their background exacerbations of the disease. The purpose of the study was to examine the preventive effi cacy of N-methylglucamine salt of acridone acetic acid (cycloferon) in complex treatment of patients with asthma according to the results of observation during 12 months. In the department of Allergology Samarkand City were examined 57 adolescents and youths with asthma aged 12 to 21 years treated drug cycloferon in a complex of basic therapy. Verifi cation of the diagnosis of asthma was conducted according to the international classifi cation and in accordance with the diagnostic criteria - GINA. Prophylactic effi cacy was assessed by clinical characteristics not earlier than one year after the course immunomodulatory therapy. All studies were performed with the informed consent of subjects and in accordance with the ethical standards. In the study of clinical data of patients treated cycloferon, with their raw data revealed a signifi cant decrease in the frequency of exacerbations during the year. Reduction of exacerbations of asthma during the year in patients receiving treatment course with the drug cycloferon, averaged 3 exacerbations per year, whereas prior to the current treatment of exacerbations of asthma recorded an average of 7 times. The average duration of an exacerbation in patients treated cycloferon, averaging 3,6 days has signifi cant differences from the index, calculated prior to the application of immunomodulators in treatment of asthma in adolescents. Thus, the courses of nonspecifi c immunotherapy drug cycloferon in asthmatic adolescents 2 times reduces the incidence of asthma exacerbations. By the absence adverse effects and improve clinical indicators cycloferon can be recommended in the complex treatment of patients with asthma in adolescents.
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