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- 저자 : ( Shiv Prakash ) (검색결과 5 건)
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Verma, Shiv Prakash,Tripathi, Vikash Chandra,Das, Parimal Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5
Aims: To evaluate anti-cancer activity of Asparagus racemosus (AR) leaf extract on UOK146, a renal cell carcinoma cell line, and explore its mechanism of action. Materials and Methods: Dried AR leaves were extracted with chloroform and dissolved in DMSO. This extract was applied to UOK146 and cell death was estimated by MTT assay. In addition PRCC-TFE3 fusion transcripts were detected by real time PCR. Results: Extract was found to be cytotoxic with an $IC_{50}$ of 0.9 mg/ml as estimated by dose response curve. Antitumor activity of the permissible doses of the extract was assessed by the down regulation of PRCC-TFE3 fusion transcript (38%) responsible for oncogenicity of the UOK146 cell line. No increment in the BAX, a proapoptotic marker level was observed. Conclusions: Evidence of antiproliferative effect, PRCC-TFE3 fusion transcript inhibition and static BAX level clearly indicate that AR extract provides or elicits an apoptosis independent anticancer effect on RCC cells by some specific mechanism of regulation.
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Verma, Shiv Prakash,Sisoudiya, Saumya,Das, Parimal Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.18
Purpose: Anti-cancer activity evaluation of aqueous extract of CRUEL (herbomineral formulation) capsules on renal cell carcinoma cell lines, and exploration of mechanisms of cell death. Materials and Methods: To detect the cytotoxic dose concentration in renal cell carcinoma (RCC) cells, MTT assays were performed and morphological changes after treatment were observed by inverted microscopy. Drug effects against RCC cell lines were assessed with reference to cell cycle distribution (flow cytometry), anti-metastatic potential (wound healing assay) and autophagy(RT-PCR). Results: CRUEL showed anti-proliferative effects against RCC tumor cell lines with an IC50 value of ${\approx}4mg/mL$ in vitro., while inducing cell cycle arrest at S-phase of cell cycle and inhibiting wound healing. LC3 was found to be up-regulated after drug treatment in RT-PCR resulting in an autophagy mode of cell death. Conclusions: This study provides the experimental validation for antitumor activity of CRUEL.
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( Omprakash Kaiwartya ),( Shiv Prakash ),( Abdul Hanan Abdullah ),( Ahmed Nazar Hassan ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.8
Energy consumption by large computing systems has become an important research theme not only because the sources of energy are depleting fast but also due to the environmental concern. Computational grid is a huge distributed computing platform for the applications that require high end computing resources and consume enormous energy to facilitate execution of jobs. The organizations which are offering services for high end computation, are more cautious about energy consumption and taking utmost steps for saving energy. Therefore, this paper proposes a scheduling technique for Minimizing Energy consumption using Adapted Genetic Algorithm (MiE-AGA) for dependent tasks in Computational Grid (CG). In MiE-AGA, fitness function formulation for energy consumption has been mathematically formulated. An adapted genetic algorithm has been developed for minimizing energy consumption with appropriate modifications in each components of original genetic algorithm such as representation of chromosome, crossover, mutation and inversion operations. Pseudo code for MiE-AGA and its components has been developed with appropriate examples. MiE-AGA is simulated using Java based programs integrated with GridSim. Analysis of simulation results in terms of energy consumption, makespan and average utilization of resources clearly reveals that MiE-AGA effectively optimizes energy, makespan and average utilization of resources in CG. Comparative analysis of the optimization performance between MiE-AGA and the state-of-the-arts algorithms: EAMM, HEFT, Min-Min and Max-Min shows the effectiveness of the model.
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Kumar Arvind,Kumar Manish,Chandra Sati Prakash,Srivastava Manish Kumar,Ghosh Surajit,Kumar Shiv 한국물리학회 2021 Current Applied Physics Vol.32 No.-
Control on the size of copper oxide (CuO) in the nano range is a highly motivating approach to study its multifunctional nature. The present investigation reports a sol-gel derived Ni doped CuO nanoparticles (Cu1- xNixO). Rietveld refinement of the XRD spectra confirms the formation of single monoclinic phase of Cu1-xNixO nanoparticles having crystallite size within the range of 19–21 nm. Raman spectra show the presence of characteristics Raman active modes and vibrational bands in the Cu1-xNixO samples that corroborate the monoclinic phase of the samples as revealed by refinement of XRD data. The estimated band gap of pure CuO is found to be ~1.43 eV, which decreases with the increase of dopant concentration into CuO matrix. This result is in line with estimated crystallite size. Magnetization curves confirm the weak ferromagnetic nature of Cu1-xNixO nanoparticles which reveal the DMS phase. This weak magnetic nature may be induced in the samples due to the exchange interaction between the localized magnetic d-spins of Ni ions and carriers (holes or electrons) from the valence band of pristine CuO lattice. Replacement of Cu+2 by Ni+2 ions into the host CuO lattice induces the magnetization. The quantified value of squareness ratio (S < 0.5) confirms the inter-grain magnetic interactions in the Cu1-xNixO nanoparticles which is also the reason of weak induced magnetization.
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Sonu Rani,Khushboo Kumari,Pankaj Kumar,Shiv Prakash,Kriti Tyagi,Sanjay R. Dhakate,Saroj Kumari 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.127 No.-
The remarkable properties exhibited by carbon fibers have generated considerable interest in seekingalternative approaches to replace time-consuming, energy-intensive, and multi-step procedures for theirsynthesis. Among the various stages involved in carbon fiber synthesis, the stabilization step plays a crucialrole as it necessitates an extended duration to transform thermoplastic pitch-fibers into thermosettingfibers, thus preventing them from melting during high-temperature treatments. In this study,isotropic coal tar pitch (ICTP) was transformed into pitch fibers through melt-spinning process and subsequentlysubjected to chemical treatment for stabilization using varying concentrations (ranging from5% to 50% v/v) of aqueous nitric acid (HNO3) solutions. The objective was to determine the optimal concentrationfor effective stabilization. Consequently, this research eliminates the conventional, timeconsumingair-stabilization process by treating the pitch fibers with nitric acid prior to carbonization. To produce carbon fibers, all chemically stabilized pitch fibers were directly carbonized at 1000 C. Comprehensive characterizations including Rheology, Elemental analysis, FTIR, TGA, FE-SEM, XRD,Raman, and XPS were conducted to investigate the chemical and structural transformations occurringduring the fiber processing. It was observed that aqueous nitric acid solutions ranging from 15% to30% (v/v) exhibited superior structural, morphological, and mechanical properties compared to otherconcentrations of HNO3.
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