Adiponectin Attenuates the Inflammation in Atopic Dermatitis-Like Reconstructed Human Epidermis

( Hee-seok Seo ),( Ki Hyun Seong ),( Chang-deok Kim ),( Seong Jun Seo ),( Byung Cheol Park ),( Myung Hwa Kim ),( Seung-phil Hong ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.2

Background: Atopic dermatitis (AD) is a chronic disorder, with a vicious cycle of repetitive inflammation and deterioration of the epidermal barrier function. Adiponectin, an adipokine, has anti-inflammatory effects on various metabolic and inflammatory disorders. Recently, its level was found to be reduced in serum and tissue samples from AD patients. Objective: We aimed to investigate the effects of adiponectin on epidermal inflammation and barrier structures in AD skin. Methods: A three-dimensional in vitro epidermal equivalent model mimicking AD was obtained by adding an inflammatory substance cocktail to normal human epidermal equivalents (HEEs). The expression of epidermal differentiation markers, primary inflammatory mediators, and lipid biosynthetic enzymes was compared between adiponectintreated AD-HEEs, untreated control AD-HEEs, and normal HEEs. Results: Adiponectin co-treatment 1) inhibited the increase in mRNA expression of major inflammatory mediators (carbonic anhydrase II, neuron-specific NEL-like protein 2, thymic stromal lymphopoietin, interleukin-8, tumor necrosis factor-alpha, and human beta-defensin-2) from keratinocytes in AD-inflammatory HEEs, 2) enhanced the expression of lipid biosynthetic enzymes (fatty acid synthase, HMG CoA reductase, and serine-palmitoyl transferase), and 3) promoted the expression of differentiation factors, especially filaggrin. We also found that the expression of adiponectin receptor-1 and -2 decreased in the epidermis of chronic AD lesion. Conclusion: Activation of the adiponectin pathway is expected to enhance epidermal differentiation and barrier function as well as attenuate inflammatory response to AD as a therapeutic approach. (Ann Dermatol 31(2) 186∼195, 2019)

스포츠마사지가 운동선수들의 피로회복에 미치는 영향에 관한 연구

서영환,나승희,위승두 한국스포츠리서치 2001 한국 스포츠 리서치 Vol.12 No.4

The purpose of this study is athletic sports for conduct appear a player is condition measure dynamic muscular endurance and a game post heart rest for measure, sports massage post of recovery time adminstration of medicine post of recovery-time nonactivity a rest examination. The conclusions were as follows: 1. This study measure of each time a record to considerably lower. The need of rest times is enough for after the exercise load. 2. A subject, the number of heart beating increase right after the exercise. 3. Sports massage be enforced administration of medicine, experimental groups, the necessary time of fatigued recovered after the exercise load 22.5 minutes. 4. Sports massage a method of treatment athletic sports treatment's effect on condition and fatigued recovery after the exercise. As a result of analyzing the change of pulse frequency after motion and the arrival time of pulse frequence at the time of rest by synthesizing the above study result, in accordance with the pulse frequency at the time of rest showed the remarkable difference. And, the arrival time of pulse frequency at the time of rest showed the reduction of 2 times or so after the execution in comparison with the time before the execution of sports massage. It can be seen that the sports massage after motion had much influence on the recovery by this. And, though there are various methods for recovering the fatigue after the motion in the point that the fatigue my be recovered within short time and the self-condition maybe maintained by executing the sports massage during match or season, it is deemed that this study result will give the important suggestion point.

작업장에서의 요통재해 발생 원인과 인간공학적 대책에 관한 연구

서승록,임완희 한국의사결정학회 1999 경영과학연구 Vol.8 No.-

The purpose of this study is to investigate the factors related to the occurrence of the low back disorder in the workplace, and to establish an appropriate intervention. As a method of study, research on actual state of back pain among workers of P manufacturing company was carried out. Data from the research was analyzed. For human engineering analysis, the form, the content and the frequency of work was surveyed. The result of this study, which contains the research on the actual state of back pain and the precise on the work process, could be used to reduce the low back disorder.

다변량 기법을 이용한 혼합치열기 분석법

서승현,안홍석,이신재,임원희,김봉래 대한치과교정학회 2009 대한치과교정학회지 Vol.39 No.2

본 연구는 다변량 기법을 도입하여 치아 크기의 다양성을 고려하면서 정확성이 높은 혼합치열기 분석법을 개발하기 위해 시행되었다. 견치 및 소구치 크기를 예측하는 데 이용된 변수는 상악 중절치, 상악 제1대구치, 하악 중절치, 하악 측절치 및 하악 제1대구치로서 총 5개 치아 크기 변수가 이용되었다. 우선 정상교합자 연구 표본 307명을 5개 치아 변수를 이용하여 k-means 군집 분석으로 치아 크기에 따라 나눈 후 판별식을 이용, 치아 크기가 큰 그룹과 작은 그룹으로 분류하였다. 이후 견치와 소구치 크기의 합을 예측하기 위하여 남녀별, 상하악별, 치아 크기 그룹별로 다중 선형 분석을 이용하여 회귀식을 구했다. 검증 표본에는 504명의 부정교합자가 이용되었으며, 이들에 대하여 정상교합자로부터 도출된 판별식을 이용하여 2그룹으로 할당한 후 정상교합자로부터 도출된 회귀식을 이용하여 상악과 하악의 견치 및 소구치 크기 합을 예측하였다. 오차 분석 결과 정상교합자는 최대 0.71, 부정교합자 검증표본은 최대 0.82 mm의 residual standard deviation 값을 보였다. 부정교합 분류별, 치아 크기 패턴별로 예측 오차의 유의한 차이는 없었다. 1 mm 및 2 mm 이상의 예측 오차를 보인 빈도는 각각 17.3%와 1.8%였다. 본 연구 결과 도출된 혼합치열기 분석법은 기존의 연구들과 비교하여 그 정확성이 높은 것으로 고찰되었다. 다만, 임상 적용 시 복잡한 계산 과정으로 인하여 전산화 환경에서 더욱 유용할 것으로 생각된다. Objective: To develop a mixed dentition analysis method in consideration of the normal variation of tooth sizes. Methods: According to the tooth-size of the maxillary central incisor, maxillary 1st molar, mandibular central incisor, mandibular lateral incisor, and mandibular 1st molar, 307 normal occlusion subjects were clustered into the smaller and larger tooth-size groups. Multiple regression analyses were then performed to predict the sizes of the canine and premolars for the 2 groups and both genders separately. For a cross validation dataset, 504 malocclusion patients were assigned into the 2 groups. Then multiple regression equations were applied. Results: Our results show that the maximum errors of the predicted space for the canine, 1st and 2nd premolars were 0.71 and 0.82 mm residual standard deviation for the normal occlusion and malocclusion groups, respectively. For malocclusion patients, the prediction errors did not imply a statistically significant difference depending on the types of malocclusion nor the types of tooth-size groups. The frequency of prediction error more than 1 mm and 2 mm were 17.3% and 1.8%, respectively. The overall prediction accuracy was dramatically improved in this study compared to that of previous studies. Conclusions: The computer aided calculation method used in this study appeared to be more efficient.

전기 철도 계통의 사고모의 및 고장점 표정

서재범,강상희,이승재 明知大學校 産業技術硏究所 2002 産業技術硏究所論文集 Vol.21 No.-

In this paper, an algorithm for fault location in Auto Transformer (AT) Feeding Railway system is presented. If a fault occurs at the AT feeding circuits of electrical railway system, it is very important to find fault location and to remove it immediately for the purpose of ensuring safety for transportation. Because the characteristics of reactance - distance are not linear, only using one terminal signals to give fault distance is difficult. In this paper, first, using the KVL, 4 voltage equation are obtained. Secondly, eliminatillg voltage a distance equation which consists of currents at rail and line parameters including mutual effects.

인슐린비의존형 당뇨병 환자에서 심전도상 QT 간격 변수들과 허혈성 심장질환 발생의 관계

서승오,진도균,박진철,진희종,임성희,유형준,박성우,박종태 대한노인병학회 2000 Annals of geriatric medicine and research Vol.4 No.3

한국전쟁기 대중소설의 서사 전략과 젠더 정치 : 이무영의 『사랑의 화첩』과 정비석의 『애정무한』을 중심으로

서승희 이화여자대학교 한국여성연구소 : 이화여자대학교 한국여성연구원 2013 여성학논집 Vol.30 No.2

한국전쟁기에 씌어진 이무영의 『사랑의 화첩』(1952)과 정비석의 『애정무한』(1951)은 전쟁이 창출한 국민국가-남한의 윤리 의식과 감정 구조를 파악하는 데 유효한 텍스트이다. 『사랑의 화첩』은 타락한 반민족주의자로 지목된 여성을 통해 전쟁기의 젠더화된 인식 체계를 재현한다. 가톨릭 사제와 수녀의 길을 걷고 있던 한 남녀는 사랑에 빠져 세속의 삶으로 돌아온다. 남편은 국가라는 이름의 신을 새로이 맞이하여 전재민 구호 사업에 투신하며, 이와 같은 민족적 대의 앞에서 아내의 개인적 욕망은 부정되고 처단 되어야 할 것으로 그려진다. 그러나 아내가 처절하게 전락하게 되는 결정적 이유는 그의 섹슈얼리티가 공산주의자를 향해 발현되었기 때문이다. 아내는 월북 후에야 북한이 지상의 지옥이라는 깨닫게 되는 한편, 중요한 것은 육체가 아니라 정신에 있다는 것을 인식하게 된다. 그러나 뒤늦은 반성은 그를 성적, 이념적 타락이라는 혐의에서 구해내지 못한다. 다시금 조우한 남편이 죽기 직전에 내뱉는 “추한 계집”이라는 말은 이 소설의 주제이자 아내의 고백에 대한 최종 선고라 할 수 있다. 반면 『애정무한』에서 여성의 섹슈얼리티는 긍정되는 것처럼 보인다. 신분을 위장하고 북측 선전실에서 근무하는 주인공은 동료 여성에게 애정을 느끼지만 갈등한다. 결코 공산주의자를 사랑할 수 없다는 것이 그 이유이다. 따라서 여성은 자신이 공산주의자가 아니라는 사실을 증명한 후 남성과의 정신적, 육체적 결합을 주도한다. 그러나 이는 주체적인 것이 아니라 남성이 욕망하는 대로 움직이는 것에 불과하다. 이 소설에서 그려지는 사랑은 전쟁이라는 폭력적 현실 속에서 자기분열과 실존적 상실을 경험하고 있는 남성적 자아의 판타지에 불과하다. 그는 자신의 환멸을 이상화된 여성을 통해 위안 받고 해소하고자 하며, 여성이 죽음을 맞이한 이후에는 낭만적인 노스탤지어를 통해 영원한 사랑을 기약한다. 이는 역사의 주인공에게만 허용되는 감정적 특권이다. 이처럼 두 소설은 각각 타락한 여성과 이상화된 여성이라는 타자를 매개로 남성-반공주의자의 주체성을 완성하고 있다는 점에서 공통된 특징을 지닌다. As full-length novels written during the Korean War, Sa-rang-eui-hawcheop(1952) by Lee, Moo-Young and Ae-jeong-moo-han(1951) by Jeong, Bi-Seok convey ethics and value reasonable for the period of war, through romantic relationships between men and women. Firstly, Sa-rang-eui-haw-cheop describes a married couple who have the shape of a virtuous nationalist and a corrupt anti-nationalist. As a Catholic priest and a nun, they fall in love and come back to the earthly life. However, for the nation and the people that the husband decided to newly serve as Gods, he devotes himself to relief work. In the presence of this cause, the wife's personal desire is regarded as trifling. In the end, the wife defects to North Korea along with her husband who is a communist. But here, North Korea is almost like hell. The wife realizes that the important things are a mind, not a body, and the people, not individuals, after being punished to fall into hell. The wife's repeated confession makes her degrade to the perfect status of a sinner, rather than save her. Therefore, the novel ends, under the assumption that she would die or get lost. On the other hand, a female desire in Ae-jeong-moo-han seems to be thought, positively. One man feels affection for a woman who is his co-worker, while working in the propaganda division of North Korea, hiding his status. This woman takes the lead in mental and physical combination with him, proving the fact she isn't a communist. However, in fact, this woman does nothing but moves as the man desires, not being independent. In this novel, the Korean War is described as violence brought about by communism which is an absolute evil, and disillusions the male character. He tries to relieve his disillusionment, by loving a dutiful woman. Thus, the female character here is merely an utopia created by the fantasy of a man experiencing self-splitting and a sense of loss. Besides, she becomes an object of romantic remembrance, by dying a death. As explained above, each of these two novels shows a corrupt woman and an idealized woman, but they are both used as tools for supporting identities of the male characters, and stress the theme, anti-communism. In this respect, they have some characteristics in common.

전신성 홍반성 루푸스에서 F-18 FDG PET상 기저핵 포도당대사 증가 소견을 보이는 무도병 1예 : Evidence for Bilateral Putaminal Hypermetabolism on F-18 FDG PET

서욱장,정선미,고수진,이창근,김재승,임주혁,유빈,문희범 대한핵의학회 2003 핵의학 분자영상 Vol.37 No.5

Purpose: We describe a 54-year-old woman with systemic lupus erythematosus (SLE) who suddenly presented with chorea and had positive antiphospholipid antibodies. F-18 FDG PET showed abnormally increased glucose metabolism in bilateral putamen and primary motor cotex. Tc-99m ECD SPECt also showed abnormally increased regional cerebral blood flow in bilateral putamen. She was treated with corticosteroid and aspirin after which the symptoms improved. Four months later, follow up F-18 FDG PET showed improvement with resolution of hypermetabolism in bilateral putamen. This case suggests that striatal hypermetabolism is associated with chorea in SLE.

뇌손상 후 인지기능장애에 대한 메칠페니데이트의 효과-이중맹검 위약대조 연구-

김연희,나승용,신용일,서정환 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.4

초등학교 제 7차 수학과 교육과정 운영 실태 분석

서승희,김민경 이화여자대학교 사범대학 교육과학연구소 2002 교육과학연구 Vol.33 No.2

이 연구는 개정된 제 7차 수학과 교육과정을 현장에서 실천하고 있는 초등 교사들을 대상으로 교육과정 운영 실태를 분석하고 현장 적용에 따른 문제점을 조사하여 개선안을 모색하고자 하였다. 이를 위해 서울시내 초등교사 1,2,3,4학년 담임교사를 대상으로 설문조사를 실시하였다. 조사 결과, 교육과정의 원활한 운영을 위한 사전연수미비, 교사들의 단위학교 수학과 교육과정개발에 대한 관심과 참여가 저조하였음이 나타났다. 또한 단계형 수준별 교육과정의 도입 취지에 대해서는 긍정적이었으나 과밀학급, 물·인적 자원지원체제 미비 등 교육환경적 요인과 보충과정 운영 및 재이수 문제 등 교육과정 자체요인으로 인해 단계형 수준별 교육과정 운영에 어려움을 겪고 있는 것으로 나타났다. 이에 국가수준의 교육과정 의도를 성공적으로 현장에 정착시키기 위해 국가 차원의 체계적이고 집중적인 교원연수 및 물·인적 자원의 지속적인 지원이 필요하며, 교사들의 합의와 숙의 과정을 통해 각 단위학교 실정에 적합한 수학과 교육과정을 개발하고, 교육운영방식을 자율적으로 선택하고 개발할 수 있도록 지원해 주어야 할 필요성이 제기되었다. The purpose of the study is investigate the way how the 7th revised elementary mathematics curriculum is recognized by teachers at school and how it is being implemented by them. This study is based on the results of the survey over teachers who teach the first, second, third and fourth graders and observations of sample classes. The survey was focused on finding out how teachers recognized, operated and adjusted the 7th mathematics curriculum. The results of the survey were as follows. The 7th mathematics curriculum was generally recognized by most teachers through inside and outside school training, not very well nor not very bad. The surveyed teachers, however, were not well aware of the program and operation of curriculum since not many of them participated in the procedures of adjusting the curriculum to each school at the beginning of the semester. It was founded that most teacher participants in survey agreed to the integration of the differentiated curriculum into classroom. However, they regarded overly populated classes, lack of supporting systems and materials, and level education as main obstacles in adjusting the 7th mathematics curriculum. Based on the results of the survey, this study suggests the followings in order to make the 7th revised mathematics curriculum be better implemented at school. Recognition and understanding of the new curriculum by teachers should be continuously enhanced through various formal and informal trainings given by national, municipal or provincial education authorities. And educational authorities should keep supporting systematic materials and information. More deliberation should be made on the differentiated curriculum which many teachers agree to find difficulty adopting at school. Each school should have more discussion on this matter and try to find way to adjust to individual school under its unique circumstances.